UniProt:P42575 CASP2

chain
  • initiator methionine:1
  • propeptide:2-169
  • chain:170-325
  • propeptide:326-333
  • chain:334-452
  • chain:348-452
checksum 6EF0ED05EF808385
comment
  • FUNCTION Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).FUNCTION Acts as a positive regulator of apoptosis.FUNCTION Acts as a negative regulator of apoptosis.FUNCTION May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death.CATALYTIC ACTIVITY Strict requirement for an Asp residue at P1, with 316-Asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.SUBUNIT Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit (PubMed:12920126). Forms a complex named the PIDDosome with PIDD1 and CRADD (PubMed:15073321, PubMed:16652156, PubMed:8985253, PubMed:9044836). Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation-dependent manner (PubMed:9560245).INTERACTION Isoforms differ in the N- and C-termini.TISSUE SPECIFICITY Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.DOMAIN The CARD domain mediates a direct interaction with CRADD.PTM The mature protease can process its own propeptide, but not that of other caspases.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase C14A family.
created [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference
databaseName UniProt
dbId 404032
description
  • recommendedName: Caspase-2 shortName: CASP-2 ecNumber: 3.4.22.55 alternativeName: Neural precursor cell expressed developmentally down-regulated protein 2 shortName: NEDD-2 alternativeName: fullName evidence="21"Protease ICH-1 component recommendedName: Caspase-2 subunit p18 /component component recommendedName: Caspase-2 subunit p13 /component component recommendedName: Caspase-2 subunit p12 /component
displayName UniProt:P42575 CASP2
geneName
  • CASP2
  • ICH1
  • NEDD2
identifier P42575
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Apoptosis
  • Disease variant
  • Hydrolase
  • Intellectual disability
  • Lissencephaly
  • Phosphoprotein
  • Protease
  • Proteomics identification
  • Reference proteome
  • Thiol protease
  • Zymogen
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • CASP2
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CASP2_HUMAN
  • A8K5F9
  • D3DXD6
  • E9PDN0
  • P42576
  • Q59F21
  • Q7KZL6
  • Q86UJ3
  • Q9BUP7
  • Q9BZK9
  • Q9BZL0
sequenceLength 452
species [Species:48887] Homo sapiens
stId uniprot:P42575
url http://purl.uniprot.org/uniprot/P42575
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