UniProt:P42126 ECI1

chain
  • transit peptide:1-41
  • chain:42-302
checksum 6E63827DE9BE886B
comment
  • FUNCTION Key enzyme of fatty acid beta-oxidation (Probable). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs (By similarity) (PubMed:7818490). The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length (By similarity).CATALYTIC ACTIVITY a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoACATALYTIC ACTIVITY a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoACATALYTIC ACTIVITY (3Z)-octenoyl-CoA = (2E)-octenoyl-CoACATALYTIC ACTIVITY (2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoACATALYTIC ACTIVITY (3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoACATALYTIC ACTIVITY (3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoACATALYTIC ACTIVITY (3Z)-decenoyl-CoA = (2E)-decenoyl-CoAPATHWAY Lipid metabolism; fatty acid beta-oxidation.SUBUNIT Homotrimer.SUBCELLULAR LOCATION Expressed in liver (at protein level).SIMILARITY Belongs to the enoyl-CoA hydratase/isomerase family.
crossReference
databaseName UniProt
dbId 53377
description
  • recommendedName: Enoyl-CoA delta isomerase 1, mitochondrial ecNumber evidence="5"5.3.3.8 alternativeName: 3,2-trans-enoyl-CoA isomerase alternativeName: fullName evidence="7"Delta(3),Delta(2)-enoyl-CoA isomerase shortName evidence="7"D3,D2-enoyl-CoA isomerase alternativeName: Dodecenoyl-CoA isomerase
displayName UniProt:P42126 ECI1
geneName
  • ECI1
  • DCI
identifier P42126
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Direct protein sequencing
  • Fatty acid metabolism
  • Isomerase
  • Lipid metabolism
  • Mitochondrion
  • Proteomics identification
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ECI1
otherIdentifier
  • 11732220_a_at
  • 1632
  • 16823087
  • 209759_PM_s_at
  • 209759_s_at
  • 3676650
  • 3676651
  • 3676653
  • 3676654
  • 3676655
  • 3676656
  • 3676657
  • 3676658
  • 3676659
  • 3676660
  • 3676662
  • 3676664
  • 3676665
  • 3676666
  • 3676667
  • 3676668
  • 37982_at
  • 7998762
  • A_23_P163647
  • GE60379
  • GE83890
  • GE85002
  • GE85003
  • GO:0003824
  • GO:0004165
  • GO:0005739
  • GO:0005759
  • GO:0006629
  • GO:0006631
  • GO:0006635
  • GO:0016853
  • GO:0016863
  • HMNXSV003040817
  • ILMN_2049303
  • L24774_s_at
  • PH_hs_0019128
  • TC16000781.hg
  • g12803812_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ECI1_HUMAN
  • A8K512
  • Q13290
  • Q7Z2L6
  • Q7Z2L7
  • Q9BUB8
  • Q9BW05
  • Q9UDG6
sequenceLength 302
species [Species:48887] Homo sapiens
stId uniprot:P42126
url http://purl.uniprot.org/uniprot/P42126
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