Reactome | UniProt:P41732 TSPAN7

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UniProt:P41732 TSPAN7 Show undefined attributes

chain	chain:1-249
checksum	F2CF4517DB388173
comment	FUNCTION May be involved in cell proliferation and cell motility.SUBUNIT (Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) UL35.INTERACTION Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the tetraspanin (TM4SF) family.
crossReference	[DatabaseIdentifier:12405413] RefSeq:NP_004606.2 [DatabaseIdentifier:12283119] Pharos - Targets:P41732 [DatabaseIdentifier:12241402] PRO:P41732 [DatabaseIdentifier:12137478] Orphanet:TSPAN7 [DatabaseIdentifier:12122799] OpenTargets:ENSG00000156298 [DatabaseIdentifier:11838292] HPA:ENSG00000156298-TSPAN7 [DatabaseIdentifier:11800725] GlyGen:P41732 [DatabaseIdentifier:11785208] GeneCards:TSPAN7 [DatabaseIdentifier:11716910] ENSEMBL:ENST00000378482 [DatabaseIdentifier:11594211] ENSEMBL:ENSP00000367743 [DatabaseIdentifier:11488698] ENSEMBL:ENSG00000156298
databaseName	UniProt
dbId	65574
description	recommendedName: Tetraspanin-7 shortName: Tspan-7 alternativeName: Cell surface glycoprotein A15 alternativeName: Membrane component chromosome X surface marker 1 alternativeName: T-cell acute lymphoblastic leukemia-associated antigen 1 shortName: TALLA-1 alternativeName: Transmembrane 4 superfamily member 2 cdAntigenNameCD231/cdAntigenName
displayName	UniProt:P41732 TSPAN7
geneName	TSPAN7 A15 DXS1692E MXS1 TM4SF2
identifier	P41732
isSequenceChanged	false
keyword	Disease variant Glycoprotein Host-virus interaction Intellectual disability Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	TSPAN7
otherIdentifier	11715752_at 11715753_a_at 11751489_a_at 17102607 202242_PM_at 202242_at 38408_at 3974020 3974021 3974025 3974026 3974035 3974036 3974049 3974052 3974053 3974054 3974055 3974056 3974057 3974064 3974065 7102 8166784 A_14_P202333 A_23_P114185 GE61018 GO:0005515 GO:0005886 GO:0016020 HMNXSV003033923 ILMN_1809291 ILMN_2120695 L10373_at PH_hs_0025757 TC0X002300.hg g4759235_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-400337] TSPAN7 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12747515] UCSC:P41732 TSPAN7 [ReferenceDNASequence:12108381] OMIM:300096 TSPAN7 [ReferenceDNASequence:12067863] NCBI Gene:7102 TSPAN7 [ReferenceDNASequence:11983770] Monarch:7102 TSPAN7 [ReferenceDNASequence:11893566] KEGG:hsa:7102 TSPAN7 [ReferenceDNASequence:11816832] HGNC:11854 TSPAN7 [ReferenceDNASequence:11438504] dbSNP Gene:7102 TSPAN7 [ReferenceDNASequence:11409561] CTD Gene:7102 TSPAN7 [ReferenceDNASequence:11401224] COSMIC - genes:TSPAN7 TSPAN7 [ReferenceDNASequence:11353981] BioGPS Gene:7102 TSPAN7 [ReferenceDNASequence:ensembl:ENSG00000156298] ENSEMBL:ENSG00000156298 TSPAN7
referenceTranscript	[ReferenceRNASequence:12587116] RefSeq:NM_004615.3 TSPAN7
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TSN7_HUMAN B2R5W7 D3DWB1 Q8WVG5 Q9UEY9
sequenceLength	249
species	[Species:48887] Homo sapiens
stId	uniprot:P41732
url	http://purl.uniprot.org/uniprot/P41732

Referrals

(interactor)	[UndirectedInteraction:11276069] UniProt:P41732 <-> UniProt:Q5JX71 (IntAct) [UndirectedInteraction:11276067] UniProt:P41732 <-> UniProt:Q8TDT2 (IntAct) [UndirectedInteraction:11276065] UniProt:P41732 <-> UniProt:Q8TAF8 (IntAct) [UndirectedInteraction:11276063] UniProt:P41732 <-> UniProt:Q6FHY5 (IntAct) [UndirectedInteraction:11204573] UniProt:Q8TDQ0 <-> UniProt:P41732 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-400337] TSPAN7 [plasma membrane]