UniProt:P41240 CSK

chain
  • initiator methionine:1
  • chain:2-450
checksum 431023A88C54E00C
comment
  • FUNCTION Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. May act as a negative regulator of EGFR and STAT3 signaling pathways (PubMed:26918609).CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Homodimer (via SH3-domain) (PubMed:19888460). Interacts with PTPN22 (PubMed:15208781). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:10790433, PubMed:10838081, PubMed:11433379, PubMed:14610046). Interacts with SRCIN1 (PubMed:17525734). Interacts with RHOH (PubMed:20851766). Interacts (via SH2 domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-107' (PubMed:21930792). Interacts (via SH2 domain) with PRAG1 (when phosphorylated at 'Tyr-391'); this interaction prevents translocation of CSK from the cytoplasm to the membrane leading to increased activity of CSK (By similarity). Interacts with LRRK1 (PubMed:23526378).INTERACTION Mainly cytoplasmic, also present in lipid rafts.TISSUE SPECIFICITY Expressed in lung and macrophages.DOMAIN The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.PTM Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
crossReference
databaseName UniProt
dbId 52852
description
  • recommendedName: Tyrosine-protein kinase CSK ecNumber evidence="14 22 24"2.7.10.2 alternativeName: C-Src kinase alternativeName: Protein-tyrosine kinase CYL
displayName UniProt:P41240 CSK
geneName
  • CSK
identifier P41240
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Adaptive immunity
  • ATP-binding
  • Cell membrane
  • Cytoplasm
  • Immunity
  • Kinase
  • Magnesium
  • Manganese
  • Membrane
  • Metal-binding
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • SH2 domain
  • SH3 domain
  • Transferase
  • Tyrosine-protein kinase
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • CSK
otherIdentifier
  • 11724484_a_at
  • 11724485_x_at
  • 11740061_a_at
  • 11751031_a_at
  • 1445
  • 16803059
  • 1768_s_at
  • 202329_PM_at
  • 202329_at
  • 3601850
  • 3601851
  • 3601852
  • 3601853
  • 3601854
  • 3601855
  • 3601856
  • 3601857
  • 3601858
  • 3601859
  • 3601860
  • 3601861
  • 3601862
  • 3601864
  • 3601865
  • 3601866
  • 3601867
  • 3601868
  • 3601869
  • 3601870
  • 3601871
  • 3601872
  • 3601873
  • 3601874
  • 3601875
  • 3601876
  • 3601877
  • 3601878
  • 3601879
  • 3601880
  • 3601881
  • 3601882
  • 3601883
  • 3601884
  • 3601885
  • 7984871
  • A_23_P152024
  • GE59856
  • GO:0000166
  • GO:0002250
  • GO:0002376
  • GO:0002682
  • GO:0003824
  • GO:0004672
  • GO:0004713
  • GO:0004715
  • GO:0005515
  • GO:0005524
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0005911
  • GO:0006468
  • GO:0008285
  • GO:0010989
  • GO:0016020
  • GO:0016301
  • GO:0016740
  • GO:0019903
  • GO:0030154
  • GO:0031295
  • GO:0032715
  • GO:0034236
  • GO:0034330
  • GO:0034332
  • GO:0035556
  • GO:0042802
  • GO:0042997
  • GO:0045779
  • GO:0046872
  • GO:0048709
  • GO:0050765
  • GO:0050852
  • GO:0050860
  • GO:0050868
  • GO:0051239
  • GO:0060368
  • GO:0070062
  • GO:0070064
  • GO:0070373
  • GO:0071375
  • GO:0140096
  • GO:1990782
  • HMNXSV003034834
  • ILMN_1754121
  • PH_hs_0004489
  • TC15000685.hg
  • X59932_s_at
  • g4758077_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CSK_HUMAN
  • Q2M3N2
  • Q6FGZ6
sequenceLength 450
species [Species:48887] Homo sapiens
stId uniprot:P41240
url http://purl.uniprot.org/uniprot/P41240

Referrals

(referenceEntity)
(interactor)
Cite Us!