Reactome | UniProt:P41221 WNT5A

chain	signal peptide:1-35 propeptide:36-61 chain:62-380
checksum	50E73AC7FE96C7B5
comment	FUNCTION Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Homooligomer; disulfide-linked, leading to inactivation (in vitro). Interacts with PORCN. Interacts with WLS (By similarity). Interacts with glypican GCP3 (PubMed:14610063). Interacts with PKD1 (via extracellular domain) (PubMed:27214281). Interacts with TMEM67 (PubMed:34731008).INTERACTION Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level) (PubMed:15735754). Detected in neonate heart and lung (PubMed:8288227).PTM Glycosylation is necessary for secretion but not for activity.PTM Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.PTM Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Wnt family.
crossReference	[DatabaseIdentifier:12400558] RefSeq:XP_047304809.1 [DatabaseIdentifier:12400568] RefSeq:XP_054203733.1 [DatabaseIdentifier:12400578] RefSeq:XP_047304816.1 [DatabaseIdentifier:12400569] RefSeq:XP_054203730.1 [DatabaseIdentifier:12400573] RefSeq:XP_047304813.1 [DatabaseIdentifier:12400575] RefSeq:XP_047304811.1 [DatabaseIdentifier:12400579] RefSeq:XP_047304815.1 [DatabaseIdentifier:12400574] RefSeq:XP_047304812.1 [DatabaseIdentifier:12400576] RefSeq:XP_047304818.1 [DatabaseIdentifier:12400570] RefSeq:XP_054203731.1 [DatabaseIdentifier:12400572] RefSeq:XP_047304814.1 [DatabaseIdentifier:12400567] RefSeq:NP_001364200.1 [DatabaseIdentifier:12400571] RefSeq:XP_011532388.1 [DatabaseIdentifier:12400577] RefSeq:XP_047304817.1 [DatabaseIdentifier:12400566] RefSeq:XP_054203732.1 [DatabaseIdentifier:12400561] RefSeq:XP_054203729.1 [DatabaseIdentifier:12400560] RefSeq:XP_016862617.1 [DatabaseIdentifier:12400556] RefSeq:XP_054203727.1 [DatabaseIdentifier:12400555] RefSeq:XP_054203728.1 [DatabaseIdentifier:11486682] ENSEMBL:ENSG00000114251 [DatabaseIdentifier:11590888] ENSEMBL:ENSP00000264634 [DatabaseIdentifier:11590889] ENSEMBL:ENSP00000417310 [DatabaseIdentifier:11590887] ENSEMBL:ENSP00000420104 [DatabaseIdentifier:11713588] ENSEMBL:ENST00000474267 [DatabaseIdentifier:11713587] ENSEMBL:ENST00000497027 [DatabaseIdentifier:11713586] ENSEMBL:ENST00000264634 [DatabaseIdentifier:11783395] GeneCards:WNT5A [DatabaseIdentifier:11836504] HPA:ENSG00000114251-WNT5A [DatabaseIdentifier:12120980] OpenTargets:ENSG00000114251 [DatabaseIdentifier:12135970] Orphanet:WNT5A [DatabaseIdentifier:12238731] PRO:P41221 [DatabaseIdentifier:12281313] Pharos - Targets:P41221 [DatabaseIdentifier:12400554] RefSeq:NP_001243034.1 [DatabaseIdentifier:12400559] RefSeq:XP_054203725.1 [DatabaseIdentifier:12400565] RefSeq:NP_001364201.1 [DatabaseIdentifier:12400557] RefSeq:XP_047304808.1 [DatabaseIdentifier:12400562] RefSeq:XP_011532390.1 [DatabaseIdentifier:12400563] RefSeq:XP_011532391.1 [DatabaseIdentifier:12400564] RefSeq:XP_047304810.1
databaseName	UniProt
dbId	67364
description	recommendedName: Protein Wnt-5a
displayName	UniProt:P41221 WNT5A
geneName	WNT5A
identifier	P41221
isSequenceChanged	false
keyword	Alternative splicing Chondrogenesis Developmental protein Differentiation Disease variant Disulfide bond Dwarfism Extracellular matrix Glycoprotein Lipoprotein Proteomics identification Reference proteome Secreted Signal Wnt signaling pathway
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	WNT5A
otherIdentifier	11727186_a_at 11727187_a_at 11727188_at 11727189_x_at 11753677_a_at 1669_at 16955197 205990_PM_s_at 205990_s_at 213425_PM_at 213425_at 2677357 2677358 2677359 2677360 2677361 2677363 2677365 2677366 2677367 2677370 2677371 2677372 2677373 2677374 2677379 2677380 2677381 31862_at 56803_at 7474 8088180 A_23_P211926 A_33_P3341499 GE57670 GO:0001736 GO:0001756 GO:0001819 GO:0001822 GO:0001837 GO:0001843 GO:0001938 GO:0001947 GO:0002009 GO:0002053 GO:0002088 GO:0002720 GO:0003138 GO:0003139 GO:0003281 GO:0003283 GO:0003323 GO:0003344 GO:0003401 GO:0003408 GO:0005102 GO:0005109 GO:0005115 GO:0005125 GO:0005515 GO:0005543 GO:0005576 GO:0005615 GO:0005788 GO:0005796 GO:0005886 GO:0006355 GO:0006954 GO:0007163 GO:0007200 GO:0007223 GO:0007254 GO:0007275 GO:0007368 GO:0007409 GO:0007411 GO:0007442 GO:0007494 GO:0008104 GO:0008283 GO:0008543 GO:0008584 GO:0008595 GO:0009952 GO:0009986 GO:0010463 GO:0010595 GO:0010628 GO:0010631 GO:0010742 GO:0010820 GO:0010976 GO:0016055 GO:0016477 GO:0019904 GO:0021891 GO:0021915 GO:0022008 GO:0022414 GO:0030154 GO:0030182 GO:0030216 GO:0030312 GO:0030324 GO:0030326 GO:0030509 GO:0030514 GO:0030666 GO:0030669 GO:0030901 GO:0031012 GO:0032722 GO:0032729 GO:0032731 GO:0032755 GO:0032757 GO:0032760 GO:0032880 GO:0034330 GO:0035022 GO:0035108 GO:0035567 GO:0036342 GO:0036517 GO:0036518 GO:0040037 GO:0042060 GO:0042472 GO:0042733 GO:0043032 GO:0043066 GO:0043122 GO:0043410 GO:0045165 GO:0045198 GO:0045599 GO:0045732 GO:0045766 GO:0045778 GO:0045807 GO:0045836 GO:0045892 GO:0045893 GO:0045944 GO:0046330 GO:0046546 GO:0048018 GO:0048022 GO:0048146 GO:0048341 GO:0048546 GO:0048570 GO:0048706 GO:0048806 GO:0048812 GO:0048843 GO:0048846 GO:0048850 GO:0048856 GO:0048870 GO:0050673 GO:0050679 GO:0050680 GO:0050727 GO:0050729 GO:0050807 GO:0050919 GO:0051057 GO:0051216 GO:0051885 GO:0051897 GO:0051964 GO:0060026 GO:0060028 GO:0060029 GO:0060065 GO:0060067 GO:0060068 GO:0060070 GO:0060071 GO:0060157 GO:0060324 GO:0060340 GO:0060599 GO:0060606 GO:0060638 GO:0060686 GO:0060744 GO:0060750 GO:0060760 GO:0060762 GO:0060809 GO:0060907 GO:0061036 GO:0061053 GO:0062009 GO:0070062 GO:0070242 GO:0070245 GO:0071219 GO:0071222 GO:0071277 GO:0071300 GO:0071346 GO:0071425 GO:0071542 GO:0071560 GO:0072089 GO:0072201 GO:0090009 GO:0090090 GO:0090103 GO:0097325 GO:0098685 GO:0098772 GO:0098794 GO:0098978 GO:0099054 GO:0099068 GO:0099170 GO:0099175 GO:0099566 GO:0140013 GO:0150012 GO:1900020 GO:1902035 GO:1902379 GO:1902474 GO:1904861 GO:1904862 GO:1904934 GO:1904948 GO:2000049 GO:2000052 GO:2000648 GO:2001235 HMNXSV003019230 Hs.152213.2.S1_3p_at ILMN_1800317 L20861_at PH_hs_0009158 TC03001482.hg g4507928_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3247799] N4GlycoAsn-PalmS WNT5A(36-380) [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3247788] N4GlycoAsn-PalmS WNT5A(36-380) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3238371] N4GlycoAsn-PalmS WNT5A(36-380) [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3238239] N4GlycoAsn-WNT5A(36-380) [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3238300] WNT5A(36-380) [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5138454] N4GlycoAsn-PalmS WNT5A(36-380) [clathrin-coated endocytic vesicle membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3781973] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3781982] N4GlycoAsn-PalmS WNT5A(36-380) [endocytic vesicle membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-517396] WNT5A [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000114251] ENSEMBL:ENSG00000114251 WNT5A [ReferenceDNASequence:12745899] UCSC:P41221 WNT5A [ReferenceDNASequence:11351950] BioGPS Gene:7474 WNT5A [ReferenceDNASequence:11400836] COSMIC - genes:WNT5A WNT5A [ReferenceDNASequence:11407046] CTD Gene:7474 WNT5A [ReferenceDNASequence:11438069] dbSNP Gene:7474 WNT5A [ReferenceDNASequence:11815011] HGNC:12784 WNT5A [ReferenceDNASequence:11891690] KEGG:hsa:7474 WNT5A [ReferenceDNASequence:11981739] Monarch:7474 WNT5A [ReferenceDNASequence:12065832] NCBI Gene:7474 WNT5A [ReferenceDNASequence:12106734] OMIM:164975 WNT5A
referenceTranscript	[ReferenceRNASequence:12582285] RefSeq:XM_054347753.1 WNT5A [ReferenceRNASequence:12582299] RefSeq:XM_047448862.1 WNT5A [ReferenceRNASequence:12582301] RefSeq:NM_001377272.1 WNT5A [ReferenceRNASequence:12582300] RefSeq:NM_001377271.1 WNT5A [ReferenceRNASequence:12582297] RefSeq:XM_011534089.2 WNT5A [ReferenceRNASequence:12582295] RefSeq:XM_047448861.1 WNT5A [ReferenceRNASequence:12582298] RefSeq:XM_047448860.1 WNT5A [ReferenceRNASequence:12582296] RefSeq:XM_011534088.3 WNT5A [ReferenceRNASequence:12582294] RefSeq:XM_011534086.3 WNT5A [ReferenceRNASequence:12582283] RefSeq:XM_054347750.1 WNT5A [ReferenceRNASequence:12582291] RefSeq:XM_047448855.1 WNT5A [ReferenceRNASequence:12582282] RefSeq:NM_001256105.1 WNT5A [ReferenceRNASequence:12582277] RefSeq:XM_047448859.1 WNT5A [ReferenceRNASequence:12582288] RefSeq:XM_047448854.1 WNT5A [ReferenceRNASequence:12582286] RefSeq:XM_054347752.1 WNT5A [ReferenceRNASequence:12582276] RefSeq:XM_054347755.1 WNT5A [ReferenceRNASequence:12582279] RefSeq:XM_054347757.1 WNT5A [ReferenceRNASequence:12582287] RefSeq:XM_047448852.1 WNT5A [ReferenceRNASequence:12582284] RefSeq:XM_017007128.2 WNT5A [ReferenceRNASequence:12582289] RefSeq:XM_047448853.1 WNT5A [ReferenceRNASequence:12582292] RefSeq:XM_047448858.1 WNT5A [ReferenceRNASequence:12582280] RefSeq:XM_054347756.1 WNT5A [ReferenceRNASequence:12582293] RefSeq:XM_047448857.1 WNT5A [ReferenceRNASequence:12582281] RefSeq:XM_054347758.1 WNT5A [ReferenceRNASequence:12582278] RefSeq:XM_054347754.1 WNT5A [ReferenceRNASequence:12582290] RefSeq:XM_047448856.1 WNT5A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	WNT5A_HUMAN A8K4A4 Q6P278
sequenceLength	380
species	[Species:48887] Homo sapiens
stId	uniprot:P41221
url	http://purl.uniprot.org/uniprot/P41221

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] [EntityWithAccessionedSequence:R-HSA-3247799] N4GlycoAsn-PalmS WNT5A(36-380) [plasma membrane] [EntityWithAccessionedSequence:R-HSA-3247788] N4GlycoAsn-PalmS WNT5A(36-380) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-3238371] N4GlycoAsn-PalmS WNT5A(36-380) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-3238239] N4GlycoAsn-WNT5A(36-380) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-3238300] WNT5A(36-380) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-5138454] N4GlycoAsn-PalmS WNT5A(36-380) [clathrin-coated endocytic vesicle membrane] [EntityWithAccessionedSequence:R-HSA-3781973] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome] [EntityWithAccessionedSequence:R-HSA-3781982] N4GlycoAsn-PalmS WNT5A(36-380) [endocytic vesicle membrane] [EntityWithAccessionedSequence:R-HSA-517396] WNT5A [extracellular region]
(referenceSequence)	[ModifiedResidue:3238202] O-palmitoleyl-L-serine at 244 [ModifiedResidue:3238141] N4-glycosyl-L-asparagine at unknown position
(interactor)	[UndirectedInteraction:11191781] UniProt:O75084 <-> UniProt:P41221 (IntAct) [UndirectedInteraction:11249101] UniProt:P41221 <-> UniProt:Q5T9L3 (IntAct) [UndirectedInteraction:11249103] UniProt:P41221 <-> UniProt:Q5T700 (IntAct) [UndirectedInteraction:11249105] UniProt:P41221 <-> UniProt:Q8N2G4 (IntAct) [UndirectedInteraction:11249107] UniProt:P41221 <-> UniProt:A6NFA1 (IntAct)

UniProt:P41221 WNT5A Show undefined attributes

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