Reactome | UniProt:P40429 RPL13A

Schema > ReferenceGeneProduct > Entries

UniProt:P40429 RPL13A Show undefined attributes

chain	initiator methionine:1 chain:2-203
checksum	3E80D0AB77A0D406
comment	FUNCTION Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318).SUBUNIT Component of the 60S ribosome (PubMed:12962325, PubMed:14567916, PubMed:23636399, PubMed:32669547). Component of the GAIT complex (PubMed:15479637). Interacts with EIF4G1 (PubMed:17218275).SUBCELLULAR LOCATION Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL13 family.
crossReference	[DatabaseIdentifier:11509307] ENSEMBL:ENSG00000142541 [DatabaseIdentifier:12448004] RefSeq:NP_001257420.1 [DatabaseIdentifier:12448005] RefSeq:NP_036555.1 [DatabaseIdentifier:12282948] Pharos - Targets:P40429 [DatabaseIdentifier:12261335] PRO:P40429 [DatabaseIdentifier:12148792] PDB:8UIK [DatabaseIdentifier:12144886] PDB:8IR3 [DatabaseIdentifier:12148785] PDB:8YOO [DatabaseIdentifier:12145985] PDB:8FKR [DatabaseIdentifier:12148788] PDB:6IP6 [DatabaseIdentifier:12139131] PDB:8FL2 [DatabaseIdentifier:12148765] PDB:6Z6L [DatabaseIdentifier:12145981] PDB:8FKP [DatabaseIdentifier:12148938] PDB:8QFD [DatabaseIdentifier:12148786] PDB:6Y57 [DatabaseIdentifier:12148766] PDB:6Z6N [DatabaseIdentifier:12145973] PDB:8FKW [DatabaseIdentifier:12145978] PDB:8FL7 [DatabaseIdentifier:12145975] PDB:8FKU [DatabaseIdentifier:12145974] PDB:8FKX [DatabaseIdentifier:12145968] PDB:8INE [DatabaseIdentifier:12148946] PDB:8QYX [DatabaseIdentifier:12148943] PDB:9GY4 [DatabaseIdentifier:12148759] PDB:8XSZ [DatabaseIdentifier:12148941] PDB:6LSR [DatabaseIdentifier:12148750] PDB:7XNY [DatabaseIdentifier:12148777] PDB:5AJ0 [DatabaseIdentifier:12144889] PDB:8INK [DatabaseIdentifier:12145977] PDB:8FKV [DatabaseIdentifier:12148789] PDB:6IP5 [DatabaseIdentifier:12148782] PDB:8YOP [DatabaseIdentifier:12148940] PDB:8OJ8 [DatabaseIdentifier:12148764] PDB:6Z6M [DatabaseIdentifier:12146421] PDB:6ZMI [DatabaseIdentifier:12148790] PDB:6IP8 [DatabaseIdentifier:12148947] PDB:7F5S [DatabaseIdentifier:12139130] PDB:8FL4 [DatabaseIdentifier:12148757] PDB:8XSY [DatabaseIdentifier:12148761] PDB:8XSX [DatabaseIdentifier:12145825] PDB:8INF [DatabaseIdentifier:12145983] PDB:8FKT [DatabaseIdentifier:12145980] PDB:8FKZ [DatabaseIdentifier:12150999] PDB:7OW7 [DatabaseIdentifier:12144887] PDB:8IR1 [DatabaseIdentifier:12148945] PDB:8FL9 [DatabaseIdentifier:12148770] PDB:8K2C [DatabaseIdentifier:12148775] PDB:8GLP [DatabaseIdentifier:12145982] PDB:8FKS [DatabaseIdentifier:12148783] PDB:9G8M [DatabaseIdentifier:12144885] PDB:8FL0 [DatabaseIdentifier:12148942] PDB:6LSS [DatabaseIdentifier:12146422] PDB:6ZMO [DatabaseIdentifier:12148944] PDB:6LU8 [DatabaseIdentifier:12148745] PDB:7XNX [DatabaseIdentifier:12144892] PDB:8IPD [DatabaseIdentifier:12148793] PDB:9B0F [DatabaseIdentifier:12144891] PDB:9QIW [DatabaseIdentifier:12148744] PDB:8IFE [DatabaseIdentifier:12148749] PDB:8IFD [DatabaseIdentifier:12144882] PDB:8IPY [DatabaseIdentifier:12139132] PDB:8FL3 [DatabaseIdentifier:12148939] PDB:8OJ5 [DatabaseIdentifier:12145976] PDB:8FL6 [DatabaseIdentifier:12144883] PDB:8IPX [DatabaseIdentifier:12148768] PDB:8QOI [DatabaseIdentifier:12145984] PDB:8FKQ [DatabaseIdentifier:12145979] PDB:8FKY [DatabaseIdentifier:12148937] PDB:8IDT [DatabaseIdentifier:12148659] PDB:8JDJ [DatabaseIdentifier:12148663] PDB:9C3H [DatabaseIdentifier:12148682] PDB:8Y0W [DatabaseIdentifier:12148933] PDB:9GMO [DatabaseIdentifier:12148696] PDB:9B0H [DatabaseIdentifier:12148667] PDB:6OLF [DatabaseIdentifier:12148669] PDB:6OLE [DatabaseIdentifier:12148672] PDB:8G5Z [DatabaseIdentifier:12148685] PDB:8Y0X [DatabaseIdentifier:12145826] PDB:8IDY [DatabaseIdentifier:12148678] PDB:8G61 [DatabaseIdentifier:12148932] PDB:8OHD [DatabaseIdentifier:12148930] PDB:7QVP [DatabaseIdentifier:12148665] PDB:8G5Y [DatabaseIdentifier:12148684] PDB:8G60 [DatabaseIdentifier:12148688] PDB:8UIZ [DatabaseIdentifier:12148704] PDB:4UG0 [DatabaseIdentifier:12145969] PDB:8FLA [DatabaseIdentifier:12148690] PDB:9B0S [DatabaseIdentifier:12148691] PDB:8UIY [DatabaseIdentifier:12148926] PDB:6Y6X [DatabaseIdentifier:12148687] PDB:9B11 [DatabaseIdentifier:12148715] PDB:9AZN [DatabaseIdentifier:12148928] PDB:8A3D [DatabaseIdentifier:12148718] PDB:9AZC [DatabaseIdentifier:12148664] PDB:8UJJ [DatabaseIdentifier:12148683] PDB:9B0O [DatabaseIdentifier:12148675] PDB:6OLI [DatabaseIdentifier:12148695] PDB:9B0G [DatabaseIdentifier:12144890] PDB:8RL2 [DatabaseIdentifier:12148923] PDB:8UJC [DatabaseIdentifier:12148689] PDB:8UJ9 [DatabaseIdentifier:12148714] PDB:5LKS [DatabaseIdentifier:12148712] PDB:6OLZ [DatabaseIdentifier:12148929] PDB:7BHP [DatabaseIdentifier:12148927] PDB:8FLC [DatabaseIdentifier:12148925] PDB:8FLF [DatabaseIdentifier:12148935] PDB:6LQM [DatabaseIdentifier:12148716] PDB:6QZP [DatabaseIdentifier:12148668] PDB:9B0W [DatabaseIdentifier:12148686] PDB:9B0P [DatabaseIdentifier:12148671] PDB:6OLG [DatabaseIdentifier:12148737] PDB:6ZM7 [DatabaseIdentifier:12148924] PDB:8UJD [DatabaseIdentifier:12145970] PDB:8FLD [DatabaseIdentifier:12148709] PDB:6OM7 [DatabaseIdentifier:12148658] PDB:8JDM [DatabaseIdentifier:12148936] PDB:6W6L [DatabaseIdentifier:12148703] PDB:8UKB [DatabaseIdentifier:12148934] PDB:8OJ0 [DatabaseIdentifier:12148661] PDB:8UJK [DatabaseIdentifier:12148697] PDB:4V6X [DatabaseIdentifier:12148657] PDB:8JDL [DatabaseIdentifier:12148680] PDB:9B0R [DatabaseIdentifier:12148662] PDB:6OM0 [DatabaseIdentifier:12148733] PDB:6XA1 [DatabaseIdentifier:12148741] PDB:9AZS [DatabaseIdentifier:12145972] PDB:8FLB [DatabaseIdentifier:12148676] PDB:8UJB [DatabaseIdentifier:12148730] PDB:6ZME [DatabaseIdentifier:12145971] PDB:8FLE [DatabaseIdentifier:12148699] PDB:6Y0G [DatabaseIdentifier:12148660] PDB:8JDK [DatabaseIdentifier:12148698] PDB:9B0N [DatabaseIdentifier:12148729] PDB:6Y2L [DatabaseIdentifier:12148694] PDB:9B0J [DatabaseIdentifier:12148679] PDB:9B0Q [DatabaseIdentifier:12148931] PDB:8IE3 [DatabaseIdentifier:12148717] PDB:5T2C [DatabaseIdentifier:12148708] PDB:8G6J [DatabaseIdentifier:12122627] OpenTargets:ENSG00000142541 [DatabaseIdentifier:11838124] HPA:ENSG00000142541-RPL13A [DatabaseIdentifier:11800591] GlyGen:P40429 [DatabaseIdentifier:11785037] GeneCards:RPL13A [DatabaseIdentifier:11746575] ENSEMBL:ENST00000391857 [DatabaseIdentifier:11623876] ENSEMBL:ENSP00000375730
databaseName	UniProt
dbId	72411
description	recommendedName: fullName evidence="13"Large ribosomal subunit protein uL13 alternativeName: 23 kDa highly basic protein alternativeName: 60S ribosomal protein L13a
displayName	UniProt:P40429 RPL13A
geneName	RPL13A
identifier	P40429
isSequenceChanged	false
keyword	3D-structure Acetylation Citrullination Cytoplasm Direct protein sequencing Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Translation regulation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPL13A
otherIdentifier	11755250_x_at 11757331_x_at 11757385_x_at 11761278_at 16707927 16864141 17119144 17119146 17119148 17119150 200715_PM_x_at 200715_x_at 200716_PM_x_at 200716_x_at 210646_PM_x_at 210646_x_at 211942_3p_x_at 211942_PM_x_at 211942_x_at 212790_PM_x_at 212790_x_at 23521 2865355 2865361 3017977 3141962 3259616 3259618 3259619 3405583 3449689 3449690 3449692 35119_at 3515420 3515421 3537038 3562984 3838576 3838579 3838580 3838581 3838582 3838583 3838584 3838585 3838586 3838587 3838588 3838589 3838590 3838591 3838592 3838593 3838594 3838595 3838596 3838597 3838598 3838599 3838600 3838601 3838602 3838603 3838604 3916472 3916474 3916475 3957510 8030351 8030360 8030362 8030364 8030366 A_21_P0000218 A_21_P0000219 A_21_P0000220 A_21_P0000221 A_23_P90143 GE81797 GO:0002181 GO:0002376 GO:0003723 GO:0003729 GO:0003735 GO:0005198 GO:0005634 GO:0005730 GO:0005737 GO:0005829 GO:0005840 GO:0005925 GO:0006412 GO:0006417 GO:0015934 GO:0016020 GO:0017148 GO:0022625 GO:0022626 GO:0032496 GO:0032819 GO:0042592 GO:0045202 GO:0048246 GO:0048870 GO:0060425 GO:0071346 GO:0097452 GO:1901194 GO:1990904 HMNXSV003005260 HMNXSV003026143 HMNXSV003026944 HMNXSV003027111 HMNXSV003031267 ILMN_1667609 ILMN_1682354 ILMN_1713369 ILMN_1743217 ILMN_2165762 PH_hs_0030383 PH_hs_0033702 RNA33606\|snoRNA_scaRNA_202_86 RNA33616\|snoRNA_scaRNA_212_83 RNA33674\|snoRNA_scaRNA_270_77 RNA33776\|snoRNA_scaRNA_372_66 TC19002198.hg TC19002606.hg X56932_at g12653484_3p_s_at g12804528_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-72412] RPL13A [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-156829] p-RPL13A [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000142541] ENSEMBL:ENSG00000142541 RPL13A [ReferenceDNASequence:12761826] UCSC:P40429 RPL13A [ReferenceDNASequence:12108223] OMIM:619225 RPL13A [ReferenceDNASequence:12088081] NCBI Gene:23521 RPL13A [ReferenceDNASequence:12003988] Monarch:23521 RPL13A [ReferenceDNASequence:11911942] KEGG:hsa:23521 RPL13A [ReferenceDNASequence:11816662] HGNC:10304 RPL13A [ReferenceDNASequence:11440586] dbSNP Gene:23521 RPL13A [ReferenceDNASequence:11409337] CTD Gene:23521 RPL13A [ReferenceDNASequence:11403022] COSMIC - genes:RPL13A RPL13A [ReferenceDNASequence:11374199] BioGPS Gene:23521 RPL13A
referenceTranscript	[ReferenceRNASequence:12629557] RefSeq:NM_001270491.1 RPL13A [ReferenceRNASequence:12629556] RefSeq:NM_012423.4 RPL13A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RL13A_HUMAN A8K505
sequenceLength	203
species	[Species:48887] Homo sapiens
stId	uniprot:P40429
url	http://purl.uniprot.org/uniprot/P40429

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-72412] RPL13A [cytosol] [EntityWithAccessionedSequence:R-HSA-156829] p-RPL13A [cytosol]
(referenceSequence)	[ModifiedResidue:156834] phosphorylated residue at unknown position
(interactor)	[UndirectedInteraction:11259665] UniProt:P40429 <-> UniProt:P62753 (IntAct) [UndirectedInteraction:11259663] UniProt:P40429 <-> UniProt:Q9HBE1 (IntAct) [UndirectedInteraction:11138221] UniProt:P63244 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11145365] UniProt:P61247 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11152805] UniProt:Q8IYB3 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11207031] UniProt:Q07020 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11209855] UniProt:Q9H6S0 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11218579] UniProt:P10636-8 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11225797] UniProt:P03372 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11237871] UniProt:Q9Y3T9 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11245727] UniProt:Q12906 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11246719] UniProt:Q14562 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11251861] UniProt:P0DTC9 <-> UniProt:P40429 (IntAct) [UndirectedInteraction:11259599] UniProt:P40429 <-> UniProt:P62913 (IntAct) [UndirectedInteraction:11259601] UniProt:P40429 <-> UniProt:P49711 (IntAct) [UndirectedInteraction:11259603] UniProt:P40429 <-> UniProt:Q15050 (IntAct) [UndirectedInteraction:11259605] UniProt:P40429 <-> UniProt:P84098 (IntAct) [UndirectedInteraction:11259607] UniProt:P40429 <-> UniProt:P06428 (IntAct) [UndirectedInteraction:11259609] UniProt:P40429 <-> UniProt:P62888 (IntAct) [UndirectedInteraction:11259611] UniProt:P40429 <-> UniProt:Q6DKI1 (IntAct) [UndirectedInteraction:11259613] UniProt:P40429 <-> UniProt:O60783 (IntAct) [UndirectedInteraction:11259615] UniProt:P40429 <-> UniProt:O75607 (IntAct) [UndirectedInteraction:11259617] UniProt:P40429 <-> UniProt:Q9NR30 (IntAct) [UndirectedInteraction:11259619] UniProt:P40429 <-> UniProt:Q9UEG4 (IntAct) [UndirectedInteraction:11259621] UniProt:P40429 <-> UniProt:P06748 (IntAct) [UndirectedInteraction:11259623] UniProt:P40429 <-> UniProt:O15381 (IntAct) [UndirectedInteraction:11259625] UniProt:P40429 <-> UniProt:Q9BYC9 (IntAct) [UndirectedInteraction:11259627] UniProt:P40429 <-> UniProt:Q15397 (IntAct) [UndirectedInteraction:11259629] UniProt:P40429 <-> UniProt:Q9BWC9 (IntAct) [UndirectedInteraction:11259631] UniProt:P40429 <-> UniProt:Q14684 (IntAct) [UndirectedInteraction:11259633] UniProt:P40429 <-> UniProt:P49406 (IntAct) [UndirectedInteraction:11259635] UniProt:P40429 <-> UniProt:P46777 (IntAct) [UndirectedInteraction:11259637] UniProt:P40429 <-> UniProt:Q14146 (IntAct) [UndirectedInteraction:11259639] UniProt:P40429 <-> UniProt:Q96K80 (IntAct) [UndirectedInteraction:11259641] UniProt:P40429 <-> UniProt:P19320 (IntAct) [UndirectedInteraction:11259643] UniProt:P40429 <-> UniProt:Q8N9T8 (IntAct) [UndirectedInteraction:11259645] UniProt:P40429 <-> UniProt:Q9UGY1 (IntAct) [UndirectedInteraction:11259647] UniProt:P40429 <-> UniProt:Q9UHB9 (IntAct) [UndirectedInteraction:11259649] UniProt:P40429 <-> UniProt:Q9GZR2 (IntAct) [UndirectedInteraction:11259651] UniProt:P40429 <-> UniProt:Q7L3S4 (IntAct) [UndirectedInteraction:11259653] UniProt:P40429 <-> UniProt:Q96PV6 (IntAct) [UndirectedInteraction:11259655] UniProt:P40429 <-> UniProt:Q15020 (IntAct) [UndirectedInteraction:11259657] UniProt:P40429 <-> UniProt:P42696 (IntAct) [UndirectedInteraction:11259659] UniProt:P40429 <-> UniProt:P62424 (IntAct) [UndirectedInteraction:11259661] UniProt:P40429 <-> UniProt:P36578 (IntAct)

Cite Us!