Reactome | UniProt:P40197 GP5

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UniProt:P40197 GP5 Show undefined attributes

chain	signal peptide:1-16 chain:17-560
checksum	B1CDB04AF8AF7115
comment	FUNCTION The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.INTERACTION Platelets and megakaryocytes.PTM The N-terminus is blocked.
crossReference	[DatabaseIdentifier:12439357] RefSeq:NP_004479.1 [DatabaseIdentifier:12279926] Pharos - Targets:P40197 [DatabaseIdentifier:12258119] PRO:P40197 [DatabaseIdentifier:12119588] OpenTargets:ENSG00000178732 [DatabaseIdentifier:11835135] HPA:ENSG00000178732-GP5 [DatabaseIdentifier:11782014] GeneCards:GP5 [DatabaseIdentifier:11739961] ENSEMBL:ENST00000692618 [DatabaseIdentifier:11739960] ENSEMBL:ENST00000401815 [DatabaseIdentifier:11617262] ENSEMBL:ENSP00000383931 [DatabaseIdentifier:11617261] ENSEMBL:ENSP00000509337 [DatabaseIdentifier:11504933] ENSEMBL:ENSG00000178732
databaseName	UniProt
dbId	55900
description	recommendedName: Platelet glycoprotein V shortName: GPV alternativeName: Glycoprotein 5 cdAntigenNameCD42d/cdAntigenName
displayName	UniProt:P40197 GP5
geneName	GP5
identifier	P40197
isSequenceChanged	false
keyword	Blood coagulation Cell adhesion Direct protein sequencing Glycoprotein Hemostasis Leucine-rich repeat Membrane Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	GP5
otherIdentifier	11738450_at 16962916 207926_PM_at 207926_at 211525_PM_s_at 211525_s_at 2711633 2711634 2711635 2711636 2711637 2711638 2711639 2711640 2711641 2711642 2814 34632_r_at 34633_s_at 8092845 A_23_P143811 A_24_P944964 GE530739 GO:0005515 GO:0005886 GO:0007155 GO:0007596 GO:0007597 GO:0007599 GO:0010572 GO:0016020 GO:0035855 GO:0048856 GO:0051209 GO:0051604 GO:0055085 GO:0070062 GO:1990779 HMNXSV003048044 ILMN_1780622 L11238_s_at PH_hs_0027675 TC03002132.hg Z23091_rna1_at g388759_3p_a_at g4758459_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-55899] GP5 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12759797] UCSC:P40197 GP5 [ReferenceDNASequence:12105478] OMIM:173511 GP5 [ReferenceDNASequence:12084350] NCBI Gene:2814 GP5 [ReferenceDNASequence:12000257] Monarch:2814 GP5 [ReferenceDNASequence:11908594] KEGG:hsa:2814 GP5 [ReferenceDNASequence:11813615] HGNC:4443 GP5 [ReferenceDNASequence:11439958] dbSNP Gene:2814 GP5 [ReferenceDNASequence:11405233] CTD Gene:2814 GP5 [ReferenceDNASequence:11402471] COSMIC - genes:GP5 GP5 [ReferenceDNASequence:11370468] BioGPS Gene:2814 GP5 [ReferenceDNASequence:ensembl:ENSG00000178732] ENSEMBL:ENSG00000178732 GP5
referenceTranscript	[ReferenceRNASequence:12620868] RefSeq:NM_004488.2 GP5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GPV_HUMAN D1MER9
sequenceLength	560
species	[Species:48887] Homo sapiens
stId	uniprot:P40197
url	http://purl.uniprot.org/uniprot/P40197

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-55899] GP5 [plasma membrane]

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