Reactome | UniProt:P38826 ORC6

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UniProt:P38826 ORC6 Show undefined attributes

chain	chain:1-435
checksum	22803C70378B7E85
comment	FUNCTION Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.SUBUNIT Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with ORC3, ORC5 and TAH11.INTERACTION Present with 2970 molecules/cell in log phase SD medium.SIMILARITY Belongs to the ORC6 family.CAUTION It is uncertain whether Met-1 or Met-3 is the initiator.SEQUENCE CAUTION Truncated N-terminus.
crossReference	[DatabaseIdentifier:12318819] RefSeq:NP_011986.1 [DatabaseIdentifier:12243950] PRO:P38826 [DatabaseIdentifier:12141992] PDB:6WGI [DatabaseIdentifier:12141999] PDB:6WGC [DatabaseIdentifier:12141998] PDB:7TJF [DatabaseIdentifier:12141995] PDB:8ZP5 [DatabaseIdentifier:12141990] PDB:5V8F [DatabaseIdentifier:12141989] PDB:7MCA [DatabaseIdentifier:12141987] PDB:8ZPK [DatabaseIdentifier:12141996] PDB:7TJH [DatabaseIdentifier:12142001] PDB:7TJI [DatabaseIdentifier:12141985] PDB:9BCX [DatabaseIdentifier:12142003] PDB:9GM5 [DatabaseIdentifier:12142002] PDB:7TJJ [DatabaseIdentifier:12141991] PDB:6WGG [DatabaseIdentifier:12142006] PDB:6RQC [DatabaseIdentifier:12142000] PDB:7TJK [DatabaseIdentifier:12142004] PDB:9GJP [DatabaseIdentifier:12141997] PDB:9GJW [DatabaseIdentifier:12142007] PDB:5ZR1 [DatabaseIdentifier:11660427] ENSEMBL:YHR118C_mRNA [DatabaseIdentifier:11537728] ENSEMBL:YHR118C [DatabaseIdentifier:11449143] ENSEMBL:YHR118C
databaseName	UniProt
dbId	97411
description	recommendedName: Origin recognition complex subunit 6 alternativeName: ACS-associated protein 1 alternativeName: Origin recognition complex 50 kDa subunit
displayName	UniProt:P38826 ORC6
geneName	ORC6 AAP1 YHR118C
identifier	P38826
isSequenceChanged	false
keyword	3D-structure Direct protein sequencing DNA replication DNA-binding Nucleus Phosphoprotein Reference proteome
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	ORC6
otherIdentifier	856518 GO:0003677 GO:0003688 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005656 GO:0005664 GO:0006260 GO:0006267 GO:0006270 GO:0006325 GO:0008150 GO:0030466 GO:0031261
physicalEntity	[EntityWithAccessionedSequence:R-SCE-9749321] yORC6 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12672539] UCSC:P38826 ORC6 [ReferenceDNASequence:12028575] NCBI Gene:856518 ORC6 [ReferenceDNASequence:11944482] Monarch:856518 ORC6 [ReferenceDNASequence:11858156] KEGG:sce:YHR118C ORC6 [ReferenceDNASequence:11314693] BioGPS Gene:856518 ORC6
referenceTranscript	[ReferenceRNASequence:12500821] RefSeq:NM_001179248.1 ORC6
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ORC6_YEAST D3DL68
sequenceLength	435
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P38826
url	http://purl.uniprot.org/uniprot/P38826

Referrals

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(referenceEntity)

[EntityWithAccessionedSequence:R-SCE-9749321] yORC6 [nucleoplasm]

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