UniProt:P37837 TALDO1

chain
  • chain:1-337
checksum 8CB4992AEF364E64
comment
  • FUNCTION Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity).CATALYTIC ACTIVITY D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphatePATHWAY Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.SUBUNIT Homodimer (PubMed:10869557). Heterodimer with isoform 2 (By similarity). Interacts with KPNA1 and KPNA4 (By similarity).INTERACTION Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1.SUBCELLULAR LOCATION Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer.ALTERNATIVE PRODUCTS The first 10 amino acids are essential for nuclear localization.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the transaldolase family. Type 1 subfamily.
crossReference
databaseName UniProt
dbId 65630
description
  • recommendedName: Transaldolase ecNumber evidence="4 6"2.2.1.2
displayName UniProt:P37837 TALDO1
geneName
  • TALDO1
  • TAL
  • TALDO
  • TALDOR
identifier P37837
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative initiation
  • Cytoplasm
  • Disease variant
  • Nucleus
  • Pentose shunt
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Schiff base
  • Transferase
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • TALDO1
otherIdentifier
  • 11715447_at
  • 11761067_at
  • 16720318
  • 201463_PM_s_at
  • 201463_s_at
  • 3316210
  • 3316211
  • 3316212
  • 3316213
  • 3316214
  • 3316215
  • 3316216
  • 3316217
  • 3316218
  • 3316219
  • 3316221
  • 3316222
  • 3316223
  • 3316224
  • 3316225
  • 3316226
  • 3316227
  • 37311_at
  • 6888
  • 7937465
  • A_23_P44993
  • A_24_P81740
  • GE58421
  • GO:0004801
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0005975
  • GO:0006002
  • GO:0006091
  • GO:0006098
  • GO:0009052
  • GO:0016740
  • GO:0019682
  • GO:0030246
  • GO:0048029
  • GO:0055086
  • GO:0070062
  • GO:1901135
  • HMNXSV003056231
  • ILMN_1670998
  • ILMN_1746588
  • L19437_at
  • PH_hs_0025684
  • TC11000027.hg
  • g5803186_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TALDO_HUMAN
  • B2R8M2
  • O00751
  • Q8WV32
  • Q8WZ45
sequenceLength 337
species [Species:48887] Homo sapiens
stId uniprot:P37837
url http://purl.uniprot.org/uniprot/P37837
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