Reactome | UniProt:P37198 NUP62

chain	initiator methionine:1 chain:2-522
checksum	1FF65018452719A3
comment	FUNCTION Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630).SUBUNIT Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58 (By similarity). Interacts with NUP88 (PubMed:30543681). Interacts with NUTF2 (By similarity). Interacts with HIKESHI (PubMed:22541429). Interacts with OSBPL8 (PubMed:21698267). Interacts with CAPG (PubMed:18266911). Interacts with SAS6 and TUBG1 at the centrosome (PubMed:24107630). Interacts with MCM3AP isoform GANP (PubMed:23652018).SUBUNIT (Microbial infection) Interacts with Epstein-barr virus BGLF4; this interaction allows BGLF4 nuclear entry.INTERACTION Central region of the nuclear pore, within the transporter (PubMed:1915414). During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630).DOMAIN Contains FG repeats.PTM O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal.PTM The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the nucleoporin NSP1/NUP62 family.
crossReference	[DatabaseIdentifier:11686355] ENSEMBL:ENST00000700478 [DatabaseIdentifier:12356479] RefSeq:NP_036478.2 [DatabaseIdentifier:12356480] RefSeq:NP_714940.1 [DatabaseIdentifier:12356481] RefSeq:NP_057637.2 [DatabaseIdentifier:12356478] RefSeq:NP_001180286.1 [DatabaseIdentifier:12356482] RefSeq:NP_714941.1 [DatabaseIdentifier:12282643] Pharos - Targets:P37198 [DatabaseIdentifier:12260796] PRO:P37198 [DatabaseIdentifier:12160446] PDB:5IJN [DatabaseIdentifier:12160447] PDB:7PER [DatabaseIdentifier:12140500] PDB:7R5J [DatabaseIdentifier:12140501] PDB:7R5K [DatabaseIdentifier:12160445] PDB:5IJO [DatabaseIdentifier:12137022] Orphanet:NUP62 [DatabaseIdentifier:12122322] OpenTargets:ENSG00000213024 [DatabaseIdentifier:11837824] HPA:ENSG00000213024-NUP62 [DatabaseIdentifier:11800238] GlyGen:P37198 [DatabaseIdentifier:11784731] GeneCards:NUP62 [DatabaseIdentifier:11686352] ENSEMBL:ENST00000700474 [DatabaseIdentifier:11686354] ENSEMBL:ENST00000700476 [DatabaseIdentifier:11686348] ENSEMBL:ENST00000599560 [DatabaseIdentifier:11686349] ENSEMBL:ENST00000700473 [DatabaseIdentifier:11686344] ENSEMBL:ENST00000599788 [DatabaseIdentifier:11686345] ENSEMBL:ENST00000597029 [DatabaseIdentifier:11686347] ENSEMBL:ENST00000596217 [DatabaseIdentifier:11686343] ENSEMBL:ENST00000352066 [DatabaseIdentifier:11686353] ENSEMBL:ENST00000700477 [DatabaseIdentifier:11686358] ENSEMBL:ENST00000600583 [DatabaseIdentifier:11686346] ENSEMBL:ENST00000596437 [DatabaseIdentifier:11686350] ENSEMBL:ENST00000598301 [DatabaseIdentifier:11686356] ENSEMBL:ENST00000422090 [DatabaseIdentifier:11686351] ENSEMBL:ENST00000700475 [DatabaseIdentifier:11467746] ENSEMBL:ENSG00000213024 [DatabaseIdentifier:11563655] ENSEMBL:ENSP00000515006 [DatabaseIdentifier:11563654] ENSEMBL:ENSP00000515014 [DatabaseIdentifier:11563658] ENSEMBL:ENSP00000515007 [DatabaseIdentifier:11563653] ENSEMBL:ENSP00000515012 [DatabaseIdentifier:11563652] ENSEMBL:ENSP00000305503 [DatabaseIdentifier:11563656] ENSEMBL:ENSP00000468839 [DatabaseIdentifier:11563659] ENSEMBL:ENSP00000515009 [DatabaseIdentifier:11563647] ENSEMBL:ENSP00000468842 [DatabaseIdentifier:11563644] ENSEMBL:ENSP00000473192 [DatabaseIdentifier:11563651] ENSEMBL:ENSP00000515013 [DatabaseIdentifier:11563650] ENSEMBL:ENSP00000515010 [DatabaseIdentifier:11563649] ENSEMBL:ENSP00000515011 [DatabaseIdentifier:11563657] ENSEMBL:ENSP00000515008 [DatabaseIdentifier:11563648] ENSEMBL:ENSP00000407331 [DatabaseIdentifier:11563645] ENSEMBL:ENSP00000471191 [DatabaseIdentifier:11563646] ENSEMBL:ENSP00000468884 [DatabaseIdentifier:11686357] ENSEMBL:ENST00000600935
databaseName	UniProt
dbId	60568
description	recommendedName: Nuclear pore glycoprotein p62 alternativeName: 62 kDa nucleoporin alternativeName: Nucleoporin Nup62
displayName	UniProt:P37198 NUP62
geneName	NUP62
identifier	P37198
isSequenceChanged	false
keyword	3D-structure Acetylation Coiled coil Cytoplasm Cytoskeleton Disease variant Disulfide bond Glycoprotein Host-virus interaction mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Translocation Transport
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	NUP62
otherIdentifier	11736409_a_at 11736410_a_at 11736411_s_at 11744599_x_at 202153_PM_s_at 202153_s_at 207740_PM_s_at 207740_s_at 23636 236505_PM_at 236505_at 3868210 3868211 3868212 3868213 3868214 3868215 3868216 3868217 3868218 3868219 3868220 3868221 3868222 3868223 3868224 3868225 3868226 3868227 3868228 3868230 3868237 3868238 3868239 3868240 3868241 3868242 39274_at 55383_at 55384_g_at 57754_at 61282_f_at 65982_at A_24_P322444 A_33_P3418010 GE56869 GE81788 GO:0000922 GO:0003682 GO:0005515 GO:0005543 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0005813 GO:0005815 GO:0005856 GO:0006355 GO:0006405 GO:0006606 GO:0006886 GO:0006913 GO:0007080 GO:0007098 GO:0007100 GO:0007166 GO:0008285 GO:0009966 GO:0015031 GO:0017056 GO:0030159 GO:0030544 GO:0031965 GO:0042059 GO:0042169 GO:0043066 GO:0043069 GO:0043123 GO:0043130 GO:0043226 GO:0044613 GO:0045742 GO:0045840 GO:0045893 GO:0046578 GO:0046580 GO:0046601 GO:0051028 GO:0051425 GO:0051879 GO:0060090 GO:0060236 GO:0072686 GO:0090398 GO:0090543 GO:0098534 GO:1903438 GO:1904781 GO:1990904 HMNXSV003011450 Hs.8832.0.A1_3p_at Hs.9877.3.S1_3p_a_at ILMN_1738681 ILMN_2323491 PH_hs_0033401 TC19002608.hg X58521_at g6912543_3p_s_at g7705354_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-157713] NUP62 [nuclear envelope] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9634226] NUP62 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000213024] ENSEMBL:ENSG00000213024 NUP62 [ReferenceDNASequence:12683051] UCSC:P37198 NUP62 [ReferenceDNASequence:12107939] OMIM:605815 NUP62 [ReferenceDNASequence:12046252] NCBI Gene:23636 NUP62 [ReferenceDNASequence:11962159] Monarch:23636 NUP62 [ReferenceDNASequence:11874033] KEGG:hsa:23636 NUP62 [ReferenceDNASequence:11816356] HGNC:8066 NUP62 [ReferenceDNASequence:11332370] BioGPS Gene:23636 NUP62 [ReferenceDNASequence:11392385] COSMIC - genes:NUP62 NUP62 [ReferenceDNASequence:11408831] CTD Gene:23636 NUP62 [ReferenceDNASequence:11428159] dbSNP Gene:23636 NUP62
referenceTranscript	[ReferenceRNASequence:12538323] RefSeq:NM_153719.4 NUP62 [ReferenceRNASequence:12538325] RefSeq:NM_012346.4 NUP62 [ReferenceRNASequence:12538326] RefSeq:NM_016553.4 NUP62 [ReferenceRNASequence:12538327] RefSeq:NM_001193357.2 NUP62 [ReferenceRNASequence:12538324] RefSeq:NM_153718.4 NUP62
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NUP62_HUMAN B3KWU5 Q503A4 Q6GTM2 Q96C43 Q9NSL1
sequenceLength	522
species	[Species:48887] Homo sapiens
stId	uniprot:P37198
url	http://purl.uniprot.org/uniprot/P37198

UniProt:P37198 NUP62 Show undefined attributes

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