Reactome | UniProt:P36871 PGM1

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UniProt:P36871 PGM1 Show undefined attributes

chain	chain:1-562
checksum	61A26C19107D467A
comment	FUNCTION Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802).CATALYTIC ACTIVITY alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphateCATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]CATALYTIC ACTIVITY alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphateCOFACTOR Binds 1 Mg(2+) ion per subunit.ACTIVITY REGULATION Glucose-1,6-bisphosphate enhances phosphorylation of the active site Ser-117, and thereby increases enzyme activity.BIOPHYSICOCHEMICAL PROPERTIES Monomer.INTERACTION Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity.POLYMORPHISM Many polymorphic variants of PGM1 exist. 8 different alleles are known: PGM11+, PGM11-, PGM12+, PGM12-, PGM13+, PGM13-, PGM17+ and PGM17-. The sequence of PGM1*1+ is shown here.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the phosphohexose mutase family.SEQUENCE CAUTION Truncated N-terminus.
crossReference	[DatabaseIdentifier:12202485] PDB:5VIN [DatabaseIdentifier:12421855] RefSeq:NP_001166289.1 [DatabaseIdentifier:12421854] RefSeq:NP_001166290.1 [DatabaseIdentifier:12421856] RefSeq:NP_002624.2 [DatabaseIdentifier:12288220] Pharos - Targets:P36871 [DatabaseIdentifier:12249301] PRO:P36871 [DatabaseIdentifier:12202476] PDB:7S77 [DatabaseIdentifier:12202484] PDB:6UIQ [DatabaseIdentifier:12202482] PDB:7S0W [DatabaseIdentifier:12202478] PDB:5VG7 [DatabaseIdentifier:12202474] PDB:5VEC [DatabaseIdentifier:11496951] ENSEMBL:ENSG00000079739 [DatabaseIdentifier:11605504] ENSEMBL:ENSP00000360124 [DatabaseIdentifier:11605502] ENSEMBL:ENSP00000443449 [DatabaseIdentifier:11605503] ENSEMBL:ENSP00000360125 [DatabaseIdentifier:11728202] ENSEMBL:ENST00000371084 [DatabaseIdentifier:11728203] ENSEMBL:ENST00000540265 [DatabaseIdentifier:11728201] ENSEMBL:ENST00000371083 [DatabaseIdentifier:11790377] GeneCards:PGM1 [DatabaseIdentifier:11806286] GlyGen:P36871 [DatabaseIdentifier:11831391] HMDB Protein:HMDBP01107 [DatabaseIdentifier:11843389] HPA:ENSG00000079739-PGM1 [DatabaseIdentifier:12127996] OpenTargets:ENSG00000079739 [DatabaseIdentifier:12136268] Orphanet:PGM1 [DatabaseIdentifier:12202483] PDB:5EPC [DatabaseIdentifier:12202477] PDB:6SNO [DatabaseIdentifier:12202471] PDB:5F9C [DatabaseIdentifier:12202472] PDB:5JN5 [DatabaseIdentifier:12202475] PDB:6SNP [DatabaseIdentifier:12202479] PDB:5HSH [DatabaseIdentifier:12202473] PDB:5TR2 [DatabaseIdentifier:12202480] PDB:5VBI [DatabaseIdentifier:12202481] PDB:6SNQ [DatabaseIdentifier:12202486] PDB:6UO6
databaseName	UniProt
dbId	61618
description	recommendedName: Phosphoglucomutase-1 shortName: PGM 1 ecNumber evidence="5 12"5.4.2.2 alternativeName: Glucose phosphomutase 1
displayName	UniProt:P36871 PGM1
geneName	PGM1
identifier	P36871
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Carbohydrate metabolism Congenital disorder of glycosylation Cytoplasm Disease variant Glucose metabolism Glycogen storage disease Isomerase Magnesium Metal-binding Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	PGM1
otherIdentifier	11748423_a_at 11756127_a_at 16665566 201968_PM_s_at 201968_s_at 2339787 2339788 2339789 2339794 2339795 2339796 2339799 2339800 2339802 2339804 2339806 2339807 2339808 2339811 2339812 2339813 2339814 2339819 2339827 2339828 2339829 2339830 2339832 2339833 32210_at 5236 7901951 A_14_P108033 A_23_P52031 GE58103 GO:0000287 GO:0004614 GO:0005515 GO:0005576 GO:0005737 GO:0005829 GO:0005975 GO:0006006 GO:0006091 GO:0006094 GO:0006096 GO:0016853 GO:0016868 GO:0033499 GO:0046872 GO:0055086 GO:0070062 GO:1901135 GO:1904724 GO:1904813 HMNXSV003003190 ILMN_1800659 M83088_at PH_hs_0000249 TC01000722.hg g4505764_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-70217] PGM1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801507] PGM1 [tertiary granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801573] PGM1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801522] PGM1 [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5609927] PGM1 D62H [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5609926] PGM1 N38Y [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5609933] PGM1 D263Y [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5609928] PGM1 R221Vfs*13 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5609931] PGM1 T115A [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000079739] ENSEMBL:ENSG00000079739 PGM1 [ReferenceDNASequence:12754196] UCSC:P36871 PGM1 [ReferenceDNASequence:11362468] BioGPS Gene:5236 PGM1 [ReferenceDNASequence:11401864] COSMIC - genes:PGM1 PGM1 [ReferenceDNASequence:11417730] CTD Gene:5236 PGM1 [ReferenceDNASequence:11439271] dbSNP Gene:5236 PGM1 [ReferenceDNASequence:11822038] HGNC:8905 PGM1 [ReferenceDNASequence:11901318] KEGG:hsa:5236 PGM1 [ReferenceDNASequence:11992257] Monarch:5236 PGM1 [ReferenceDNASequence:12076350] NCBI Gene:5236 PGM1 [ReferenceDNASequence:12112806] OMIM:171900 PGM1
referenceTranscript	[ReferenceRNASequence:12603426] RefSeq:NM_002633.2 PGM1 [ReferenceRNASequence:12603427] RefSeq:NM_001172819.2 PGM1 [ReferenceRNASequence:12603425] RefSeq:NM_001172818.1 PGM1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PGM1_HUMAN B2R5N9 B4DPV0 Q16105 Q16106 Q5BKZ9 Q6NW22 Q86U74 Q96J40 Q9NTY4
sequenceLength	562
species	[Species:48887] Homo sapiens
stId	uniprot:P36871
url	http://purl.uniprot.org/uniprot/P36871

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