Reactome | UniProt:P36507 MAP2K2

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UniProt:P36507 MAP2K2 Show undefined attributes

chain	chain:1-400
checksum	3401D522515C30A5
comment	FUNCTION Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Interacts with MORG1 (By similarity). Interacts with SGK1 (PubMed:19447520). Interacts with KSR1 (PubMed:10409742). Interacts with KSR1 and BRAF; the interaction with KSR1 mediates KSR1-BRAF dimerization (PubMed:29433126). Interacts with GLS (PubMed:22538822).INTERACTION Membrane localization is probably regulated by its interaction with KSR1.PTM MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).PTM (Microbial infection) Acetylation of Ser-222 and Ser-226 by Yersinia YopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
crossReference	[DatabaseIdentifier:11492943] ENSEMBL:ENSG00000126934 [DatabaseIdentifier:12817883] ZINC - World Drugs:MP2K2_HUMAN [DatabaseIdentifier:12816136] ZINC target:P36507 [DatabaseIdentifier:12812757] ZINC - Substances:MP2K2_HUMAN [DatabaseIdentifier:12808333] ZINC - Predictions - Purchasable:MP2K2_HUMAN [DatabaseIdentifier:12806406] ZINC - Investigational:MP2K2_HUMAN [DatabaseIdentifier:12805347] ZINC - FDA approved:MP2K2_HUMAN [DatabaseIdentifier:12804155] ZINC - Biogenic:MP2K2_HUMAN [DatabaseIdentifier:12285641] Pharos - Targets:P36507 [DatabaseIdentifier:12245326] PRO:P36507 [DatabaseIdentifier:12153118] PDB:4H3Q [DatabaseIdentifier:12178816] PDB:1S9I [DatabaseIdentifier:12136756] Orphanet:MAP2K2 [DatabaseIdentifier:12125338] OpenTargets:ENSG00000126934 [DatabaseIdentifier:11840795] HPA:ENSG00000126934-MAP2K2 [DatabaseIdentifier:11832143] HMDB Protein:HMDBP09528 [DatabaseIdentifier:11803210] GlyGen:P36507 [DatabaseIdentifier:11787722] GeneCards:MAP2K2 [DatabaseIdentifier:11778842] Guide to Pharmacology - Targets:2063 [DatabaseIdentifier:11722969] ENSEMBL:ENST00000262948 [DatabaseIdentifier:11600270] ENSEMBL:ENSP00000262948
databaseName	UniProt
dbId	59505
description	recommendedName: Dual specificity mitogen-activated protein kinase kinase 2 shortName: MAP kinase kinase 2 shortName: MAPKK 2 ecNumber evidence="7"2.7.12.2 alternativeName: ERK activator kinase 2 alternativeName: MAPK/ERK kinase 2 shortName: MEK 2
displayName	UniProt:P36507 MAP2K2
geneName	MAP2K2 MEK2 MKK2 PRKMK2
identifier	P36507
isSequenceChanged	false
keyword	3D-structure Acetylation ATP-binding Cardiomyopathy Cytoplasm Direct protein sequencing Disease variant Ectodermal dysplasia Intellectual disability Kinase Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	MAP2K2
otherIdentifier	1131_at 11716318_x_at 16867240 202424_PM_at 202424_at 213490_PM_s_at 213490_s_at 3023305 3023308 3023309 3023310 3846639 3846640 3846643 3846644 3846645 3846646 3846647 3846648 3846649 3846650 3846651 3846652 3846653 3846654 3846655 3846656 3846659 3846660 3846663 3846664 3846665 3846666 5605 8032761 A_23_P208835 GE57609 GO:0000165 GO:0000166 GO:0003824 GO:0004672 GO:0004674 GO:0004708 GO:0004712 GO:0004713 GO:0005078 GO:0005515 GO:0005524 GO:0005576 GO:0005634 GO:0005737 GO:0005739 GO:0005768 GO:0005769 GO:0005770 GO:0005778 GO:0005783 GO:0005794 GO:0005829 GO:0005874 GO:0005911 GO:0005925 GO:0006355 GO:0006468 GO:0007507 GO:0009898 GO:0010628 GO:0014044 GO:0016020 GO:0016301 GO:0016740 GO:0030165 GO:0030878 GO:0032872 GO:0036289 GO:0038133 GO:0042552 GO:0043226 GO:0043539 GO:0045893 GO:0046872 GO:0048009 GO:0048471 GO:0048538 GO:0048679 GO:0048856 GO:0050772 GO:0060090 GO:0060324 GO:0060425 GO:0060440 GO:0060502 GO:0070371 GO:0071902 GO:0090170 GO:0097110 GO:0098772 GO:0106310 GO:0140096 GO:2000147 GO:2000641 HMNXSV003002037 Hs.72241.1.S1_3p_a_at ILMN_1657968 L11285_at PH_hs_0029886 TC19001058.hg g13489053_3p_at g13489053_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-169292] p-S222,S226-MAP2K2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-59504] MAP2K2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-109848] p-S,T-MAP2K2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652079] MAP2K2 N126D [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652076] MAP2K2 L46F [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652073] MAP2K2 F57C [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652089] MAP2K2 Y134C [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652086] MAP2K2 V35M [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652082] MAP2K2 P128Q [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9652070] MAP2K2 C125S [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5211337] MAP2K2(11-400) [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5211334] MAP2K2(1-10) [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000126934] ENSEMBL:ENSG00000126934 MAP2K2 [ReferenceDNASequence:12751551] UCSC:P36507 MAP2K2 [ReferenceDNASequence:12110657] OMIM:601263 MAP2K2 [ReferenceDNASequence:12072385] NCBI Gene:5605 MAP2K2 [ReferenceDNASequence:11988292] Monarch:5605 MAP2K2 [ReferenceDNASequence:11897745] KEGG:hsa:5605 MAP2K2 [ReferenceDNASequence:11819368] HGNC:6842 MAP2K2 [ReferenceDNASequence:11439069] dbSNP Gene:5605 MAP2K2 [ReferenceDNASequence:11413642] CTD Gene:5605 MAP2K2 [ReferenceDNASequence:11401698] COSMIC - genes:MAP2K2 MAP2K2 [ReferenceDNASequence:11358503] BioGPS Gene:5605 MAP2K2
referenceTranscript	[ReferenceRNASequence:12595874] RefSeq:NM_030662.4 MAP2K2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MP2K2_HUMAN
sequenceLength	400
species	[Species:48887] Homo sapiens
stId	uniprot:P36507
url	http://purl.uniprot.org/uniprot/P36507

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-169292] p-S222,S226-MAP2K2 [cytosol] [EntityWithAccessionedSequence:R-HSA-59504] MAP2K2 [cytosol] [EntityWithAccessionedSequence:R-HSA-109848] p-S,T-MAP2K2 [cytosol] [EntityWithAccessionedSequence:R-HSA-9652079] MAP2K2 N126D [cytosol] [EntityWithAccessionedSequence:R-HSA-9652076] MAP2K2 L46F [cytosol] [EntityWithAccessionedSequence:R-HSA-9652073] MAP2K2 F57C [cytosol] [EntityWithAccessionedSequence:R-HSA-9652089] MAP2K2 Y134C [cytosol] [EntityWithAccessionedSequence:R-HSA-9652086] MAP2K2 V35M [cytosol] [EntityWithAccessionedSequence:R-HSA-9652082] MAP2K2 P128Q [cytosol] [EntityWithAccessionedSequence:R-HSA-9652070] MAP2K2 C125S [cytosol] [EntityWithAccessionedSequence:R-HSA-5211337] MAP2K2(11-400) [cytosol] [EntityWithAccessionedSequence:R-HSA-5211334] MAP2K2(1-10) [cytosol]
(referenceSequence)	[ModifiedResidue:169290] O-phospho-L-serine at 226 [ModifiedResidue:169288] O-phospho-L-serine at 222 [ModifiedResidue:109847] O-phospho-L-threonine at unknown position [ModifiedResidue:109846] O-phospho-L-serine at unknown position [ReplacedResidue:9651856] L-asparagine 126 replaced with L-aspartic acid [ReplacedResidue:9651869] L-leucine 46 replaced with L-phenylalanine [ReplacedResidue:9651886] L-phenylalanine 57 replaced with L-cysteine [ReplacedResidue:9651896] L-tyrosine 134 replaced with L-cysteine [ReplacedResidue:9651898] L-valine 35 replaced with L-methionine [ReplacedResidue:9651893] L-proline 128 replaced with L-glutamine [ReplacedResidue:9651861] L-cysteine 125 replaced with L-serine
(interactor)	[UndirectedInteraction:11230401] UniProt:P36507 <-> UniProt:Q9NQZ2 (IntAct) [UndirectedInteraction:11230399] UniProt:P36507 <-> UniProt:P06929 (IntAct) [UndirectedInteraction:11230397] UniProt:P36507 <-> UniProt:Q61097 (IntAct) [UndirectedInteraction:11230395] UniProt:P36507 <-> UniProt:O75175 (IntAct) [UndirectedInteraction:11230393] UniProt:P36507 <-> UniProt:P32970 (IntAct) [UndirectedInteraction:11230391] UniProt:P36507 <-> UniProt:Q58FG1 (IntAct) [UndirectedInteraction:11230389] UniProt:P36507 <-> UniProt:Q58FG0 (IntAct) [UndirectedInteraction:11230387] UniProt:P36507 <-> UniProt:Q58FF6 (IntAct) [UndirectedInteraction:11230385] UniProt:P36507 <-> UniProt:P04439 (IntAct) [UndirectedInteraction:11230383] UniProt:P36507 <-> UniProt:P08238 (IntAct) [UndirectedInteraction:11230381] UniProt:P36507 <-> UniProt:hspa1a_hspa1b_human-1 (IntAct) [UndirectedInteraction:11230379] UniProt:P36507 <-> UniProt:Q16543 (IntAct) [UndirectedInteraction:11230377] UniProt:P36507 <-> UniProt:P05120 (IntAct) [UndirectedInteraction:11230375] UniProt:P36507 <-> UniProt:P63104 (IntAct) [UndirectedInteraction:11230373] UniProt:P36507 <-> UniProt:P62258 (IntAct) [UndirectedInteraction:11230371] UniProt:P36507 <-> UniProt:Q9BQE3 (IntAct) [UndirectedInteraction:11139159] UniProt:P31946 <-> UniProt:P36507 (IntAct) [UndirectedInteraction:11199749] UniProt:P15056 <-> UniProt:P36507 (IntAct) [UndirectedInteraction:11207671] UniProt:O95816 <-> UniProt:P36507 (IntAct) [UndirectedInteraction:11210251] UniProt:P07437 <-> UniProt:P36507 (IntAct) [UndirectedInteraction:11222905] UniProt:P07900 <-> UniProt:P36507 (IntAct) [UndirectedInteraction:11230333] UniProt:P36507 <-> UniProt:P10398 (IntAct) [UndirectedInteraction:11230335] UniProt:P36507 <-> UniProt:P04049 (IntAct) [UndirectedInteraction:11230337] UniProt:P36507 <-> UniProt:Q8IVT5 (IntAct) [UndirectedInteraction:11230339] UniProt:P36507 <-> UniProt:P27348 (IntAct) [UndirectedInteraction:11230341] UniProt:P36507 <-> UniProt:Q04917 (IntAct) [UndirectedInteraction:11230343] UniProt:P36507 <-> UniProt:Q12959 (IntAct) [UndirectedInteraction:11230345] UniProt:P36507 <-> UniProt:P61981 (IntAct) [UndirectedInteraction:11230347] UniProt:P36507 <-> UniProt:Q02750 (IntAct) [UndirectedInteraction:11230349] UniProt:P36507 <-> UniProt:P11142 (IntAct) [UndirectedInteraction:11230351] UniProt:P36507 <-> UniProt:Q6VAB6 (IntAct) [UndirectedInteraction:11230353] UniProt:P36507 <-> UniProt:P68366 (IntAct) [UndirectedInteraction:11230357] UniProt:P36507 <-> UniProt:Q96II5 (IntAct) [UndirectedInteraction:11230359] UniProt:P36507 <-> UniProt:O96018 (IntAct) [UndirectedInteraction:11230361] UniProt:P36507 <-> UniProt:P00540 (IntAct) [UndirectedInteraction:11230363] UniProt:P36507 <-> UniProt:P05067 (IntAct) [UndirectedInteraction:11230365] UniProt:P36507 <-> UniProt:O95273 (IntAct) [UndirectedInteraction:11230367] UniProt:P36507 <-> UniProt:P61978-2 (IntAct) [UndirectedInteraction:11230369] UniProt:P36507 <-> UniProt:Q92905 (IntAct)

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