UniProt:P36383 GJC1

chain
  • chain:1-396
checksum C9F67C1D926D40DF
comment
  • FUNCTION Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (PubMed:24077100, PubMed:31992625, PubMed:40010341).CATALYTIC ACTIVITY 2',3'-cGAMP(out) = 2',3'-cGAMP(in)CATALYTIC ACTIVITY 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine(out) = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine(in)SUBUNIT A connexon/hemichannel is composed of a hexamer of connexins. Forms functional homotypic gap junctions consisting of identical hemichannels both made of the same connexin type as well as heterotypic gap junctions consisting of two different hemichannels, each containing a different type of connexin. Assembles with GJA1 to form heterotypic gap junction channels (By similarity). Interacts with CNST (By similarity).INTERACTION Belongs to the connexin family. Gamma-type subfamily.
crossReference
databaseName UniProt
dbId 53200
description
  • recommendedName: Gap junction gamma-1 protein alternativeName: Connexin-45 shortName: Cx45 alternativeName: Gap junction alpha-7 protein
displayName UniProt:P36383 GJC1
geneName
  • GJC1
  • GJA7
identifier P36383
isSequenceChanged false
keyword
  • 3D-structure
  • Cell junction
  • Cell membrane
  • Gap junction
  • Immunity
  • Innate immunity
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • GJC1
otherIdentifier
  • 10052
  • 11740256_s_at
  • 11753126_s_at
  • 11754438_x_at
  • 16845736
  • 208460_PM_at
  • 208460_at
  • 228563_PM_at
  • 228563_at
  • 228776_PM_at
  • 228776_at
  • 231048_PM_at
  • 231048_at
  • 243502_PM_at
  • 243502_at
  • 33041_at
  • 3759332
  • 3759334
  • 3759336
  • 3759337
  • 3759338
  • 3759339
  • 3759340
  • 3759341
  • 3759342
  • 3759343
  • 3759344
  • 3759345
  • 3759346
  • 3759347
  • 3759348
  • 3759349
  • 3759351
  • 3759355
  • 41927_at
  • 45229_at
  • 59139_at
  • 8016094
  • 81220_at
  • 87504_at
  • A_23_P428287
  • A_32_P702236
  • A_33_P3373358
  • GE62949
  • GE85625
  • GO:0001570
  • GO:0003012
  • GO:0005216
  • GO:0005243
  • GO:0005515
  • GO:0005654
  • GO:0005783
  • GO:0005789
  • GO:0005886
  • GO:0005921
  • GO:0005922
  • GO:0006936
  • GO:0007043
  • GO:0007154
  • GO:0007267
  • GO:0007268
  • GO:0007507
  • GO:0007601
  • GO:0014704
  • GO:0016020
  • GO:0016264
  • GO:0030154
  • GO:0034220
  • GO:0034330
  • GO:0045202
  • GO:0048468
  • GO:0048738
  • GO:0048856
  • GO:0050877
  • GO:0055085
  • GO:0070161
  • GO:0086014
  • GO:0086020
  • GO:0086021
  • GO:0086053
  • GO:0086077
  • HMNXSV003006828
  • Hs.193480.0.A1_3p_at
  • Hs.245330.0.A1_3p_at
  • Hs.43761.0.A1_3p_at
  • Hs.43761.1.A1_3p_at
  • ILMN_1687023
  • ILMN_2397484
  • PH_hs_0011414
  • PH_hs_0026533
  • TC17001585.hg
  • g4885168_3p_at
  • p6853
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CXG1_HUMAN
  • B3KW68
  • Q4VAY0
sequenceLength 396
species [Species:48887] Homo sapiens
stId uniprot:P36383
url http://purl.uniprot.org/uniprot/P36383
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