UniProt:P35548 MSX2

chain
  • chain:1-267
checksum 5B61B75F4A7C4AFD
comment
  • FUNCTION Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.SUBUNIT Interacts with MINT (By similarity). Interacts with XRCC6 (Ku70) and XRCC5 (Ku80).INTERACTION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Msh homeobox family.
crossReference
databaseName UniProt
dbId 59609
description
  • recommendedName: Homeobox protein MSX-2 alternativeName: Homeobox protein Hox-8
displayName UniProt:P35548 MSX2
geneName
  • MSX2
  • HOX8
identifier P35548
isSequenceChanged false
keyword
  • Craniosynostosis
  • Developmental protein
  • Disease variant
  • DNA-binding
  • Homeobox
  • Nucleus
  • Osteogenesis
  • Proteomics identification
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • MSX2
otherIdentifier
  • 11730340_x_at
  • 11759030_a_at
  • 16992622
  • 205555_PM_s_at
  • 205555_s_at
  • 210319_3p_x_at
  • 210319_PM_x_at
  • 210319_x_at
  • 2841966
  • 2841967
  • 2841968
  • 2841970
  • 2841971
  • 2841972
  • 2841973
  • 2841974
  • 2841975
  • 3728612
  • 3728620
  • 3728622
  • 40733_f_at
  • 40734_r_at
  • 4488
  • 8110084
  • A_24_P132006
  • A_24_P132008
  • D89377_at
  • D89377_s_at
  • GE58290
  • GO:0000122
  • GO:0000785
  • GO:0000976
  • GO:0000977
  • GO:0000978
  • GO:0000981
  • GO:0001227
  • GO:0001503
  • GO:0001649
  • GO:0002063
  • GO:0002076
  • GO:0003148
  • GO:0003151
  • GO:0003161
  • GO:0003198
  • GO:0003416
  • GO:0003677
  • GO:0005515
  • GO:0005634
  • GO:0005667
  • GO:0005829
  • GO:0006355
  • GO:0006357
  • GO:0007507
  • GO:0008285
  • GO:0009887
  • GO:0009952
  • GO:0016607
  • GO:0023019
  • GO:0030154
  • GO:0030326
  • GO:0030509
  • GO:0030513
  • GO:0035115
  • GO:0035116
  • GO:0035313
  • GO:0035880
  • GO:0042060
  • GO:0042476
  • GO:0042733
  • GO:0042981
  • GO:0043066
  • GO:0043565
  • GO:0045599
  • GO:0045617
  • GO:0045669
  • GO:0045892
  • GO:0048598
  • GO:0048856
  • GO:0048863
  • GO:0048870
  • GO:0051216
  • GO:0051795
  • GO:0060346
  • GO:0060349
  • GO:0060363
  • GO:0060364
  • GO:0060444
  • GO:0061180
  • GO:0061311
  • GO:0070166
  • GO:0071363
  • GO:0071392
  • GO:0090427
  • GO:0097152
  • GO:1990837
  • GO:2001055
  • HMNXSV003012723
  • ILMN_1766951
  • PH_hs_0004979
  • TC05000974.hg
  • g1321637_3p_a_at
  • g1722693_3p_a_at
  • g1722693_3p_x_at
  • g6996018_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MSX2_HUMAN
  • D3DQN1
  • Q53XM4
  • Q9UD60
sequenceLength 267
species [Species:48887] Homo sapiens
stId uniprot:P35548
url http://purl.uniprot.org/uniprot/P35548

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