UniProt:P35249 RFC4

chain
  • chain:1-363
checksum 6FEAB3794379F3E0
comment
  • FUNCTION Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble.SUBUNIT Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA (PubMed:8999859, PubMed:9488738, PubMed:39106866). Forms an heterotetrameric complex with RFC2, RFC3 and RFC5; this complex has ATPase activity but is not stimulated by PCNA (PubMed:9488738). The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17 (PubMed:11572977). Interacts with ATAD5(PubMed:39106866). Interacts with CTF18 (PubMed:39106866). Interacts with CNTD1; this interaction facilitates crossover formation (By similarity).INTERACTION The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP.SIMILARITY Belongs to the activator 1 small subunits family.
crossReference
databaseName UniProt
dbId 99889
description
  • recommendedName: Replication factor C subunit 4 alternativeName: Activator 1 37 kDa subunit shortName: A1 37 kDa subunit alternativeName: Activator 1 subunit 4 alternativeName: Replication factor C 37 kDa subunit shortName: RF-C 37 kDa subunit shortName: RFC37
displayName UniProt:P35249 RFC4
geneName
  • RFC4
identifier P35249
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • ATP-binding
  • Deafness
  • Direct protein sequencing
  • DNA replication
  • Nucleotide-binding
  • Nucleus
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • RFC4
otherIdentifier
  • 1054_at
  • 1055_g_at
  • 11722872_a_at
  • 11761625_at
  • 11761626_x_at
  • 16962493
  • 204023_PM_at
  • 204023_at
  • 2709487
  • 2709488
  • 2709489
  • 2709490
  • 2709491
  • 2709492
  • 2709493
  • 2709494
  • 2709495
  • 2709496
  • 2709497
  • 2709498
  • 2709499
  • 2709500
  • 2709501
  • 2709502
  • 2709503
  • 2709504
  • 2709505
  • 2709506
  • 2709507
  • 2709508
  • 2709509
  • 2709510
  • 5984
  • 8092640
  • A_23_P18196
  • GE79366
  • GO:0000166
  • GO:0003677
  • GO:0003689
  • GO:0003824
  • GO:0005515
  • GO:0005524
  • GO:0005634
  • GO:0005654
  • GO:0005663
  • GO:0005694
  • GO:0006260
  • GO:0006261
  • GO:0006271
  • GO:0006281
  • GO:0016787
  • GO:0016887
  • GO:0017116
  • GO:0019899
  • GO:0031390
  • GO:0031391
  • GO:0140097
  • GO:0140657
  • GO:1900264
  • HMNXSV003037223
  • ILMN_1724489
  • ILMN_2370365
  • M87339_at
  • PH_hs_0002862
  • TC03002088.hg
  • g4506490_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RFC4_HUMAN
  • B4DM41
  • D3DNV2
  • Q6FHX7
sequenceLength 363
species [Species:48887] Homo sapiens
stId uniprot:P35249
url http://purl.uniprot.org/uniprot/P35249
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