UniProt:P35232 PHB1

chain
  • initiator methionine:1
  • chain:2-272
checksum 915494273E342C76
comment
  • FUNCTION Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).FUNCTION In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117).FUNCTION In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195).FUNCTION In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).SUBUNIT The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Interacts with STOML2 (PubMed:21746876). Interacts with MAP1LC3B (membrane-bound form LC3-II); the interaction requires PHB2 and takes place upon Parkin-mediated mitochondrial damage (PubMed:28017329). Interacts with STAT3 (unphosphorylated or phosphorylated at 'Ser-727') (PubMed:31899195). Interacts with CLPB (PubMed:31522117). Interacts with CD86 (via cytoplasmic domain); the interactions increases after priming with CD40 (By similarity).SUBUNIT (Microbial infection) Interacts with SARS coronavirus/SARS-CoV nsp2 protein.SUBUNIT (Microbial infection) Interacts with chikungunya virus spike glycoprotein E2.SUBUNIT (Microbial infection) Interaction with human immunodeficiency virus type 1/HIV-1 envelope glycoprotein GP160.SUBUNIT (Microbial infection) Interacts with human enterovirus 71/EV-71 capsid protein VP0, protein 3CD and protease 3C.INTERACTION Widely expressed in different tissues.DEVELOPMENTAL STAGE Levels of expression in fibroblasts decrease heterogeneously during cellular aging (PubMed:11302691). In CD4(+) T cells, expression increases during polarization towards T-helper Th17, Th1 and Th2 (PubMed:31899195).INDUCTION Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.SIMILARITY Belongs to the prohibitin family.
crossReference
databaseName UniProt
dbId 61648
description
  • recommendedName: fullName evidence="18"Prohibitin 1
displayName UniProt:P35232 PHB1
geneName
  • PHB1
  • PHB
identifier P35232
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cell membrane
  • Coiled coil
  • Cytoplasm
  • Direct protein sequencing
  • DNA synthesis
  • Host-virus interaction
  • Membrane
  • Mitochondrion
  • Mitochondrion inner membrane
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Proto-oncogene
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • PHB1
otherIdentifier
  • 11720609_at
  • 11720610_x_at
  • 11751776_a_at
  • 16846416
  • 200658_PM_s_at
  • 200658_s_at
  • 200659_PM_s_at
  • 200659_s_at
  • 2338404
  • 3328113
  • 3453061
  • 3453064
  • 3454751
  • 36592_at
  • 3660848
  • 3761807
  • 3761808
  • 3761809
  • 3761810
  • 3761811
  • 3761812
  • 3761813
  • 3761814
  • 3761815
  • 3761816
  • 3761817
  • 3761818
  • 3761819
  • 3761820
  • 3761821
  • 3761822
  • 3761823
  • 3761824
  • 3761825
  • 3761826
  • 4016898
  • 5245
  • 8016552
  • 80405_f_at
  • A_23_P130040
  • A_24_P262355
  • GE61229
  • GO:0000122
  • GO:0001649
  • GO:0001850
  • GO:0001851
  • GO:0002376
  • GO:0002639
  • GO:0003714
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005739
  • GO:0005743
  • GO:0005768
  • GO:0005769
  • GO:0005886
  • GO:0006325
  • GO:0006355
  • GO:0007005
  • GO:0007165
  • GO:0008285
  • GO:0009986
  • GO:0010628
  • GO:0010944
  • GO:0016020
  • GO:0019899
  • GO:0030154
  • GO:0030308
  • GO:0031871
  • GO:0032740
  • GO:0035632
  • GO:0039529
  • GO:0040029
  • GO:0042113
  • GO:0042177
  • GO:0042826
  • GO:0042981
  • GO:0043525
  • GO:0044830
  • GO:0045745
  • GO:0045892
  • GO:0045893
  • GO:0045917
  • GO:0046718
  • GO:0046982
  • GO:0048661
  • GO:0050821
  • GO:0050847
  • GO:0051897
  • GO:0060766
  • GO:0070062
  • GO:0070373
  • GO:0070374
  • GO:0071354
  • GO:0071897
  • GO:0072538
  • GO:0140374
  • GO:1901224
  • GO:2000323
  • HMNXSV003057895
  • Hs.75323.0.A1_3p_a_at
  • ILMN_1692651
  • PH_hs_0004311
  • S85655_at
  • TC17001664.hg
  • g6031190_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PHB1_HUMAN
  • B4DY47
  • Q4VBQ0
sequenceLength 272
species [Species:48887] Homo sapiens
stId uniprot:P35232
url http://purl.uniprot.org/uniprot/P35232
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