Reactome | UniProt:P35226 BMI1

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UniProt:P35226 BMI1 Show undefined attributes

chain	chain:1-326
checksum	030A7D396BADA543
comment	FUNCTION Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:26151332, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:21772249, PubMed:26151332).SUBUNIT Component of a PRC1-like complex (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:21772249, PubMed:25355358, PubMed:26151332). Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2 (PubMed:12167701). Interacts with RNF2/RING2 (PubMed:16714294, PubMed:21772249, PubMed:25355358). Interacts with RING1 (By similarity). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2 (PubMed:21772249, PubMed:25355358). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). Interacts with CBX7 and CBX8 (PubMed:19636380). Interacts with SPOP (PubMed:15897469). Part of a complex consisting of BMI1, CUL3 and SPOP (PubMed:15897469). Interacts with E4F1 (PubMed:16882984). Interacts with PHC2 (PubMed:27827373, PubMed:9121482, PubMed:9199346). Interacts with zinc finger protein ZNF277 (By similarity). May be part of a complex including at least ZNF277, BMI1 and RNF2/RING2 (By similarity).INTERACTION Down-regulated by oxidative stress.PTM Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.MISCELLANEOUS The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.
crossReference	[DatabaseIdentifier:12165958] PDB:4R8P [DatabaseIdentifier:12285572] Pharos - Targets:P35226 [DatabaseIdentifier:12264822] PRO:P35226 [DatabaseIdentifier:12178529] PDB:6WI8 [DatabaseIdentifier:12159200] PDB:8GRM [DatabaseIdentifier:12178533] PDB:2H0D [DatabaseIdentifier:11513819] ENSEMBL:ENSG00000168283 [DatabaseIdentifier:11629950] ENSEMBL:ENSP00000365851 [DatabaseIdentifier:11752649] ENSEMBL:ENST00000376663 [DatabaseIdentifier:11787652] GeneCards:BMI1 [DatabaseIdentifier:11803130] GlyGen:P35226 [DatabaseIdentifier:11840725] HPA:ENSG00000168283-BMI1 [DatabaseIdentifier:12125267] OpenTargets:ENSG00000168283 [DatabaseIdentifier:12178530] PDB:5FR6 [DatabaseIdentifier:12178532] PDB:2NA1 [DatabaseIdentifier:12170545] PDB:3RPG [DatabaseIdentifier:12166079] PDB:9DGG [DatabaseIdentifier:12160250] PDB:9DBY [DatabaseIdentifier:12160269] PDB:9DDE [DatabaseIdentifier:12165918] PDB:8PP7 [DatabaseIdentifier:12178531] PDB:6WI7 [DatabaseIdentifier:12178534] PDB:7ND1
databaseName	UniProt
dbId	50886
description	recommendedName: Polycomb complex protein BMI-1 alternativeName: Polycomb group RING finger protein 4 alternativeName: RING finger protein 51
displayName	UniProt:P35226 BMI1
geneName	BMI1 PCGF4 RNF51
identifier	P35226
isSequenceChanged	false
keyword	3D-structure Chromatin regulator Cytoplasm Metal-binding Nucleus Proteomics identification Proto-oncogene Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	BMI1
otherIdentifier	11743395_s_at 11756843_a_at 1728_at 202265_PM_at 202265_at 2601877 3238489 3238490 3238492 3238493 3238494 3238495 3238496 3238497 3238498 3238499 3238500 3238501 3238502 3238503 3238504 3238505 3238506 3238507 3238508 3238509 3238510 3238511 3238512 3238513 3238514 3238515 3238516 41562_at 648 7926609 A_14_P135457 A_23_P314115 A_24_P303989 GE57630 GO:0000122 GO:0000151 GO:0000792 GO:0001501 GO:0001701 GO:0002376 GO:0003682 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006325 GO:0006338 GO:0006346 GO:0006355 GO:0006959 GO:0007379 GO:0007420 GO:0008270 GO:0010468 GO:0016604 GO:0021903 GO:0030097 GO:0030890 GO:0031519 GO:0033092 GO:0035102 GO:0045814 GO:0046872 GO:0048103 GO:0048146 GO:0048704 GO:0048706 GO:0048856 GO:0051443 GO:0071347 GO:0071535 GO:0071549 GO:0090183 GO:0097027 GO:0097190 GO:0098772 GO:1990841 GO:2000011 GO:2001234 HMNXSV003033732 ILMN_1700915 L13689_at PH_hs_0018497 TC10002935.hg g4885094_3p_at g4885094_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-389121] BMI1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3229116] p-S-BMI1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4551729] monoSUMO1-K88-BMI1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000168283] ENSEMBL:ENSG00000168283 BMI1 [ReferenceDNASequence:12764319] UCSC:P35226 BMI1 [ReferenceDNASequence:11378310] BioGPS Gene:648 BMI1 [ReferenceDNASequence:11378309] BioGPS Gene:100532731 BMI1 [ReferenceDNASequence:11403378] COSMIC - genes:BMI1 BMI1 [ReferenceDNASequence:11413524] CTD Gene:648 BMI1 [ReferenceDNASequence:11413523] CTD Gene:100532731 BMI1 [ReferenceDNASequence:11440987] dbSNP Gene:100532731 BMI1 [ReferenceDNASequence:11440988] dbSNP Gene:648 BMI1 [ReferenceDNASequence:11819297] HGNC:1066 BMI1 [ReferenceDNASequence:11915592] KEGG:hsa:648 BMI1 [ReferenceDNASequence:11915593] KEGG:hsa:100532731 BMI1 [ReferenceDNASequence:12008099] Monarch:648 BMI1 [ReferenceDNASequence:12008098] Monarch:100532731 BMI1 [ReferenceDNASequence:12092192] NCBI Gene:648 BMI1 [ReferenceDNASequence:12092191] NCBI Gene:100532731 BMI1 [ReferenceDNASequence:12110598] OMIM:164831 BMI1
referenceTranscript	[ReferenceRNASequence:12637864] RefSeq:NM_001204062.1 BMI1 [ReferenceRNASequence:12637868] RefSeq:NM_001428310.1 BMI1 [ReferenceRNASequence:12637869] RefSeq:NM_001428311.1 BMI1 [ReferenceRNASequence:12637867] RefSeq:NM_001428312.1 BMI1 [ReferenceRNASequence:12637866] RefSeq:NM_005180.8 BMI1 [ReferenceRNASequence:12637865] RefSeq:NM_001428309.1 BMI1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BMI1_HUMAN Q16030 Q5T8Z3 Q96F37
sequenceLength	326
species	[Species:48887] Homo sapiens
stId	uniprot:P35226
url	http://purl.uniprot.org/uniprot/P35226

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-389121] BMI1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3229116] p-S-BMI1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4551729] monoSUMO1-K88-BMI1 [nucleoplasm]
(referenceSequence)	[ModifiedResidue:3229113] O-phospho-L-serine at unknown position [GroupModifiedResidue:4551702] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 88
(interactor)	[UndirectedInteraction:11135347] UniProt:O94906 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11140587] UniProt:P17096 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11158589] UniProt:P0CG48 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11193433] UniProt:P35227 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11216111] UniProt:Q93009 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11223161] UniProt:Q01523 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11247393] UniProt:Q15910 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11257773] UniProt:P60484 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11262827] UniProt:P20226 <-> UniProt:P35226 (IntAct) [UndirectedInteraction:11294917] UniProt:P68400 <-> UniProt:P35226 (IntAct)