UniProt:P35213 Ywhab

chain
  • chain:1-246
  • initiator methionine:1
  • chain:2-246
checksum B663D1F2182F9C43
comment
  • FUNCTION Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.SUBUNIT Homodimer (By similarity). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2. Interacts with YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2 (By similarity). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C. Interacts with SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity). Interacts with SLITRK1. Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form); this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-439' and inhibits TESK1 kinase activity (PubMed:11555644). Interacts with MEFV (By similarity). Interacts with HDAC4 (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity).INTERACTION The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.PTM Isoform Short contains a N-acetylmethionine at position 1.SIMILARITY Belongs to the 14-3-3 family.
crossReference
databaseName UniProt
dbId 84075
description
  • recommendedName: 14-3-3 protein beta/alpha alternativeName: Prepronerve growth factor RNH-1 alternativeName: Protein kinase C inhibitor protein 1 shortName: KCIP-1 component recommendedName: 14-3-3 protein beta/alpha, N-terminally processed /component
displayName UniProt:P35213 Ywhab
geneName
  • Ywhab
identifier P35213
isSequenceChanged false
keyword
  • Acetylation
  • Alternative initiation
  • Cytoplasm
  • Direct protein sequencing
  • Isopeptide bond
  • Nitration
  • Phosphoprotein
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • Ywhab
otherIdentifier
  • 10842052
  • 1386999_at
  • 1398800_at
  • 17768738
  • 56011
  • 5943680
  • 5972222
  • 6211343
  • 6488739
  • 6703977
  • 6710292
  • 6725565
  • A_44_P195306
  • A_44_P255254
  • GE1197891
  • GO:0004860
  • GO:0004864
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0006355
  • GO:0006605
  • GO:0019899
  • GO:0019904
  • GO:0042308
  • GO:0042802
  • GO:0042826
  • GO:0045744
  • GO:0045944
  • GO:0048471
  • GO:0050815
  • GO:0051219
  • GO:0098772
  • GO:0140311
  • ILMN_1350344
  • PH_rn_0011427
  • S55223_s_at
  • rc_AA924084_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • 1433B_RAT
sequenceLength 246
species [Species:48895] Rattus norvegicus
stId uniprot:P35213
url http://purl.uniprot.org/uniprot/P35213
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