Reactome | UniProt:P34998 CRHR1

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UniProt:P34998 CRHR1 Show undefined attributes

chain	signal peptide:1-23 chain:24-415
checksum	81445283CCE34C6E
comment	FUNCTION G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.SUBUNIT Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts (via N-terminal extracellular domain) with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding.INTERACTION Agonist-binding promotes endocytosis.ALTERNATIVE PRODUCTS Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.DOMAIN The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure. The antagonist CP-376395 binds at an allosteric site, far from the presumed binding site for the physiological peptide ligand.PTM C-terminal Ser or Thr residues may be phosphorylated.PTM Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.MISCELLANEOUS Major isoform.MISCELLANEOUS Does not bind to CRF with high affinity.SIMILARITY Belongs to the G-protein coupled receptor 2 family.
crossReference	[DatabaseIdentifier:12220402] PDB:8GTM [DatabaseIdentifier:12815377] ZINC target:P34998 [DatabaseIdentifier:12812029] ZINC - Substances:CRFR1_HUMAN [DatabaseIdentifier:12810068] ZINC - Predictions - Purchasable:CRFR1_HUMAN [DatabaseIdentifier:12807922] ZINC - Metabolites:CRFR1_HUMAN [DatabaseIdentifier:12806651] ZINC - Investigational:CRFR1_HUMAN [DatabaseIdentifier:12804429] ZINC - Biogenic:CRFR1_HUMAN [DatabaseIdentifier:12341604] RefSeq:NP_004373.2 [DatabaseIdentifier:12341608] RefSeq:NP_001138620.1 [DatabaseIdentifier:12341605] RefSeq:NP_001138618.1 [DatabaseIdentifier:12341606] RefSeq:NP_001138619.1 [DatabaseIdentifier:12341603] RefSeq:NP_001243228.1 [DatabaseIdentifier:12341607] RefSeq:NP_001289947.1 [DatabaseIdentifier:12291894] Pharos - Targets:P34998 [DatabaseIdentifier:12254017] PRO:P34998 [DatabaseIdentifier:12220405] PDB:3EHT [DatabaseIdentifier:12220404] PDB:3EHS [DatabaseIdentifier:12220407] PDB:2L27 [DatabaseIdentifier:12220408] PDB:8GTG [DatabaseIdentifier:12164415] PDB:6PB0 [DatabaseIdentifier:12164628] PDB:6P9X [DatabaseIdentifier:12220410] PDB:8GTI [DatabaseIdentifier:12220403] PDB:4K5Y [DatabaseIdentifier:11460621] ENSEMBL:ENSG00000278232 [DatabaseIdentifier:11460620] ENSEMBL:ENSG00000276191 [DatabaseIdentifier:11460622] ENSEMBL:ENSG00000120088 [DatabaseIdentifier:11553540] ENSEMBL:ENSP00000480752 [DatabaseIdentifier:11553532] ENSEMBL:ENSP00000484387 [DatabaseIdentifier:11553531] ENSEMBL:ENSP00000480396 [DatabaseIdentifier:11553537] ENSEMBL:ENSP00000381333 [DatabaseIdentifier:11553536] ENSEMBL:ENSP00000344068 [DatabaseIdentifier:11553534] ENSEMBL:ENSP00000488342 [DatabaseIdentifier:11553533] ENSEMBL:ENSP00000478177 [DatabaseIdentifier:11553541] ENSEMBL:ENSP00000462016 [DatabaseIdentifier:11553535] ENSEMBL:ENSP00000326060 [DatabaseIdentifier:11553538] ENSEMBL:ENSP00000477786 [DatabaseIdentifier:11553539] ENSEMBL:ENSP00000483802 [DatabaseIdentifier:11676233] ENSEMBL:ENST00000617905 [DatabaseIdentifier:11676235] ENSEMBL:ENST00000616748 [DatabaseIdentifier:11676238] ENSEMBL:ENST00000615345 [DatabaseIdentifier:11676240] ENSEMBL:ENST00000577353 [DatabaseIdentifier:11676236] ENSEMBL:ENST00000618382 [DatabaseIdentifier:11676234] ENSEMBL:ENST00000616274 [DatabaseIdentifier:11676230] ENSEMBL:ENST00000613260 [DatabaseIdentifier:11676231] ENSEMBL:ENST00000398285 [DatabaseIdentifier:11676237] ENSEMBL:ENST00000352855 [DatabaseIdentifier:11676239] ENSEMBL:ENST00000633723 [DatabaseIdentifier:11676232] ENSEMBL:ENST00000314537 [DatabaseIdentifier:11780485] Guide to Pharmacology - Targets:212 [DatabaseIdentifier:11794057] GeneCards:CRHR1 [DatabaseIdentifier:11810005] GlyGen:P34998 [DatabaseIdentifier:11847042] HPA:ENSG00000120088-CRHR1 [DatabaseIdentifier:12131708] OpenTargets:ENSG00000120088 [DatabaseIdentifier:12220409] PDB:4Z9G [DatabaseIdentifier:12220406] PDB:3EHU
databaseName	UniProt
dbId	52782
description	recommendedName: fullName evidence="13"Corticotropin-releasing factor receptor 1 shortName: CRF-R-1 shortName: CRF-R1 shortName: CRFR-1 alternativeName: Corticotropin-releasing hormone receptor 1 shortName: CRH-R-1 shortName: CRH-R1
displayName	UniProt:P34998 CRHR1
geneName	CRHR1 CRFR CRFR1 CRHR
identifier	P34998
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Endosome G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	CRHR1
otherIdentifier	104909134 11732003_a_at 1394 208593_PM_x_at 208593_x_at 211897_PM_s_at 211897_s_at 214619_PM_at 214619_at 3723635 3723636 3723637 3723641 3723642 3723645 3723646 3723647 3723650 3723652 3723653 3723654 3723655 3723656 3723657 3723658 3723659 3723660 3723661 3723662 3723663 3723664 3723666 3723668 40650_r_at 40651_s_at 8007808 A_23_P414884 A_33_P3320443 A_33_P3402817 GE59979 GO:0002376 GO:0004888 GO:0004930 GO:0005515 GO:0005768 GO:0005886 GO:0006955 GO:0007165 GO:0007166 GO:0007186 GO:0007189 GO:0007190 GO:0007565 GO:0007567 GO:0008528 GO:0009755 GO:0015056 GO:0016020 GO:0022414 GO:0030325 GO:0032870 GO:0035640 GO:0042596 GO:0043005 GO:0043404 GO:0048149 GO:0048856 GO:0051049 GO:0051424 GO:0051458 GO:0051867 GO:0071376 GO:0098839 GO:0098978 GO:1901386 GO:2000852 HMNXSV003003341 HMNXSV003025307 HMNXSV003056595 Hs.79117.3.S2_3p_at ILMN_1732426 ILMN_1753706 L23333_s_at PH_hs_0025074 TC17002239.hg TC17002876.hg TC17_ctg5_hap1000028.hg X72304_at g5815472_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-420166] CRHR1 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000120088] ENSEMBL:ENSG00000120088 CRHR1 [ReferenceDNASequence:12731246] UCSC:P34998 CRHR1 [ReferenceDNASequence:11325178] BioGPS Gene:1394 CRHR1 [ReferenceDNASequence:11398472] COSMIC - genes:CRHR1 CRHR1 [ReferenceDNASequence:11422719] CTD Gene:1394 CRHR1 [ReferenceDNASequence:11435290] dbSNP Gene:1394 CRHR1 [ReferenceDNASequence:11825752] HGNC:2357 CRHR1 [ReferenceDNASequence:11867611] KEGG:hsa:104909134 CRHR1 [ReferenceDNASequence:11867610] KEGG:hsa:1394 CRHR1 [ReferenceDNASequence:11954967] Monarch:1394 CRHR1 [ReferenceDNASequence:12039060] NCBI Gene:1394 CRHR1 [ReferenceDNASequence:12116143] OMIM:122561 CRHR1
referenceTranscript	[ReferenceRNASequence:12523487] RefSeq:NM_001256299.2 CRHR1 [ReferenceRNASequence:12523488] RefSeq:NM_004382.4 CRHR1 [ReferenceRNASequence:12523485] RefSeq:NM_001145147.2 CRHR1 [ReferenceRNASequence:12523484] RefSeq:NM_001303018.2 CRHR1 [ReferenceRNASequence:12523483] RefSeq:NM_001145146.2 CRHR1 [ReferenceRNASequence:12523486] RefSeq:NM_001145148.2 CRHR1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CRFR1_HUMAN B4DIE9 Q13008 Q4QRJ1 Q9UK64
sequenceLength	415
species	[Species:48887] Homo sapiens
stId	uniprot:P34998
url	http://purl.uniprot.org/uniprot/P34998

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-420166] CRHR1 [plasma membrane]
(interactor)	[UndirectedInteraction:11136751] UniProt:P06850 <-> UniProt:P34998 (IntAct) [UndirectedInteraction:11213453] UniProt:Q14160 <-> UniProt:P34998 (IntAct) [UndirectedInteraction:11293171] UniProt:Q12959 <-> UniProt:P34998 (IntAct)

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