UniProt:P34931 HSPA1L

chain
  • chain:1-641
checksum A9339D7657166FF7
comment
  • FUNCTION Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).SUBUNIT Interacts with PRKN.INTERACTION Expressed in spermatids.INDUCTION Not induced by heat shock.DOMAIN The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.SIMILARITY Belongs to the heat shock protein 70 family.
crossReference
databaseName UniProt
dbId 56694
description
  • recommendedName: Heat shock 70 kDa protein 1-like shortName: Heat shock 70 kDa protein 1L alternativeName: Heat shock 70 kDa protein 1-Hom shortName: HSP70-Hom alternativeName: Heat shock protein family A member 1L
displayName UniProt:P34931 HSPA1L
geneName
  • HSPA1L
identifier P34931
isSequenceChanged false
keyword
  • 3D-structure
  • ATP-binding
  • Nucleotide-binding
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • HSPA1L
otherIdentifier
  • 11727138_a_at
  • 17017485
  • 17026864
  • 17029337
  • 17032123
  • 17039574
  • 210189_PM_at
  • 210189_at
  • 2949451
  • 2949452
  • 2949453
  • 2949454
  • 2949455
  • 2949456
  • 2949457
  • 3305
  • 40656_at
  • 8125134
  • 8178650
  • 8179848
  • A_23_P70547
  • GE57353
  • GE81523
  • GO:0000166
  • GO:0002199
  • GO:0005515
  • GO:0005524
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0006950
  • GO:0006986
  • GO:0007339
  • GO:0008180
  • GO:0016787
  • GO:0016887
  • GO:0031072
  • GO:0031625
  • GO:0042026
  • GO:0044183
  • GO:0044297
  • GO:0051082
  • GO:0072562
  • GO:0140662
  • GO:1903955
  • HMNXSV003012431
  • ILMN_1654566
  • M59829_at
  • PH_hs_0004622
  • TC06001546.hg
  • TC6_apd_hap1000087.hg
  • TC6_cox_hap2000173.hg
  • TC6_dbb_hap3000162.hg
  • TC6_qbl_hap6000163.hg
  • g3461865_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HS71L_HUMAN
  • A6NNB0
  • B0UXW8
  • O75634
  • Q2HXR3
  • Q8NE72
  • Q96QC9
  • Q9UQM1
sequenceLength 641
species [Species:48887] Homo sapiens
stId uniprot:P34931
url http://purl.uniprot.org/uniprot/P34931
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