Reactome | UniProt:P34925 RYK

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UniProt:P34925 RYK Show undefined attributes

chain	signal peptide:1-25 chain:26-607
checksum	3AFAE21A2680F400
comment	FUNCTION May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Interacts with DVL1 (via PDZ domain).SUBCELLULAR LOCATION In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.ALTERNATIVE PRODUCTS Observed in all the tissues examined.DOMAIN The extracellular WIF domain is responsible for Wnt binding.PTM Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family.CAUTION According to some authors, has impaired kinase activity.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:12333745] RefSeq:NP_002949.2 [DatabaseIdentifier:12333744] RefSeq:NP_001005861.1 [DatabaseIdentifier:12288999] Pharos - Targets:P34925 [DatabaseIdentifier:12250418] PRO:P34925 [DatabaseIdentifier:12206690] PDB:6TUA [DatabaseIdentifier:12128781] OpenTargets:ENSG00000163785 [DatabaseIdentifier:11844161] HPA:ENSG00000163785-RYK [DatabaseIdentifier:11832558] HMDB Protein:HMDBP01453 [DatabaseIdentifier:11807123] GlyGen:P34925 [DatabaseIdentifier:11791154] GeneCards:RYK [DatabaseIdentifier:11779295] Guide to Pharmacology - Targets:1849 [DatabaseIdentifier:11670796] ENSEMBL:ENST00000620660 [DatabaseIdentifier:11670797] ENSEMBL:ENST00000623711 [DatabaseIdentifier:11548098] ENSEMBL:ENSP00000485095 [DatabaseIdentifier:11548097] ENSEMBL:ENSP00000478721 [DatabaseIdentifier:11456800] ENSEMBL:ENSG00000163785
databaseName	UniProt
dbId	403788
description	recommendedName: fullName evidence="15"Tyrosine-protein kinase RYK ecNumber evidence="3"2.7.10.1
displayName	UniProt:P34925 RYK
geneName	RYK JTK5A
identifier	P34925
isSequenceChanged	false
keyword	3D-structure Alternative splicing ATP-binding Cytoplasm Disulfide bond Glycoprotein Kinase Membrane Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase Wnt signaling pathway
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	RYK
otherIdentifier	11740589_s_at 16959412 202853_PM_s_at 202853_s_at 214172_PM_x_at 214172_x_at 216976_PM_s_at 216976_s_at 232205_PM_at 232205_at 2696202 2696203 2696204 2696241 2696243 2696245 2696247 2696249 2696251 2696253 2696254 2696255 2696256 2696257 2696258 2696261 2696262 2696264 2696265 2696266 2696267 2696269 2696271 2696272 2696273 2696274 2696278 2696279 2696280 2696281 2696282 2696287 2696292 2696293 2696295 2696296 3706890 3706892 3706895 3706896 3706898 37756_at 539_at 6259 8090840 83879_at A_21_P0002880 A_24_P229377 A_32_P114372 A_33_P3379371 GE514515 GE58784 GE85449 GO:0000166 GO:0003824 GO:0004672 GO:0004713 GO:0004888 GO:0005109 GO:0005515 GO:0005524 GO:0005634 GO:0005737 GO:0005886 GO:0006468 GO:0007165 GO:0007169 GO:0007409 GO:0007411 GO:0007416 GO:0010976 GO:0015026 GO:0016020 GO:0016055 GO:0016301 GO:0016740 GO:0017147 GO:0022008 GO:0022038 GO:0030154 GO:0030182 GO:0031175 GO:0034330 GO:0035567 GO:0036518 GO:0042813 GO:0043235 GO:0043410 GO:0048705 GO:0048787 GO:0048843 GO:0048846 GO:0048856 GO:0050919 GO:0051897 GO:0060070 GO:0060071 GO:0071679 GO:0098839 GO:0098978 GO:0140096 GO:1904935 GO:1904948 HMNXSV003003782 HMNXSV003009303 Hs.158923.0.S1_3p_at Hs.79350.2.S1_3p_a_at ILMN_1658526 ILMN_1769671 ILMN_1818617 ILMN_1855117 ILMN_2363439 PH_hs_0009642 PH_hs_0040130 S59184_at TC03003100.hg TC03003101.hg TC03003415.hg TC03003416.hg g11863158_3p_a_at g11863158_3p_x_at p11512
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3006746] RYK [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12728960] UCSC:P34925 RYK [ReferenceDNASequence:12113502] OMIM:600524 RYK [ReferenceDNASequence:12035478] NCBI Gene:6259 RYK [ReferenceDNASequence:11951385] Monarch:6259 RYK [ReferenceDNASequence:11864338] KEGG:hsa:6259 RYK [ReferenceDNASequence:11822823] HGNC:10481 RYK [ReferenceDNASequence:11435037] dbSNP Gene:6259 RYK [ReferenceDNASequence:11418779] CTD Gene:6259 RYK [ReferenceDNASequence:11398246] COSMIC - genes:RYK RYK [ReferenceDNASequence:11321596] BioGPS Gene:6259 RYK [ReferenceDNASequence:ensembl:ENSG00000163785] ENSEMBL:ENSG00000163785 RYK
referenceTranscript	[ReferenceRNASequence:12515639] RefSeq:NM_001005861.3 RYK [ReferenceRNASequence:12515638] RefSeq:NM_002958.4 RYK
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RYK_HUMAN A0A087WUK1 A0A096LNL3 Q04696
sequenceLength	607
species	[Species:48887] Homo sapiens
stId	uniprot:P34925
url	http://purl.uniprot.org/uniprot/P34925

Referrals

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(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-3006746] RYK [plasma membrane]