UniProt:P33260 CYP2C18

chain
  • signal peptide:1-25
  • chain:26-490
checksum C933CF31F078FD1E
comment
  • FUNCTION A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).CATALYTIC ACTIVITY an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)COFACTOR Cofactor metabolism; retinol metabolism.SUBCELLULAR LOCATION Belongs to the cytochrome P450 family.
crossReference
databaseName UniProt
dbId 52676
description
  • recommendedName: Cytochrome P450 2C18 ecNumber evidence="3"1.14.14.1 alternativeName: CYPIIC18 alternativeName: Cytochrome P450-6b/29c
displayName UniProt:P33260 CYP2C18
geneName
  • CYP2C18
identifier P33260
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Endoplasmic reticulum
  • Heme
  • Iron
  • Lipid metabolism
  • Membrane
  • Metal-binding
  • Microsome
  • Monooxygenase
  • Oxidoreductase
  • Proteomics identification
  • Reference proteome
  • Signal
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • CYP2C18
otherIdentifier
  • 11735076_a_at
  • 11735077_a_at
  • 11735078_s_at
  • 1477_s_at
  • 1562
  • 16707729
  • 208126_PM_s_at
  • 208126_s_at
  • 215103_PM_at
  • 215103_at
  • 3258967
  • 3258968
  • 3258969
  • 3258970
  • 3258972
  • 3258973
  • 3258974
  • 3258975
  • 3258976
  • 3258979
  • 3258980
  • 3258981
  • 3258983
  • 3258984
  • 3258986
  • 3258989
  • 3258994
  • 3258995
  • 3258996
  • 3259054
  • 7929466
  • A_14_P130455
  • A_23_P52480
  • GE58010
  • GO:0004497
  • GO:0005506
  • GO:0005737
  • GO:0005783
  • GO:0005789
  • GO:0005886
  • GO:0006629
  • GO:0006721
  • GO:0006805
  • GO:0008392
  • GO:0008401
  • GO:0016020
  • GO:0016491
  • GO:0016705
  • GO:0016712
  • GO:0019369
  • GO:0019373
  • GO:0019825
  • GO:0020037
  • GO:0032787
  • GO:0042178
  • GO:0042572
  • GO:0042573
  • GO:0043651
  • GO:0046872
  • GO:0071614
  • HMNXSV003002186
  • Hs.702.0.S1_3p_at
  • ILMN_1683121
  • M61853_at
  • TC10002972.hg
  • g13699815_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CP2CI_HUMAN
  • B2R8K2
  • Q16703
  • Q16751
  • Q4VAT5
  • Q6GRG1
sequenceLength 490
species [Species:48887] Homo sapiens
stId uniprot:P33260
url http://purl.uniprot.org/uniprot/P33260
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