UniProt:P33240 CSTF2

chain
  • chain:1-577
checksum B76595E9BF8FABBD
comment
  • FUNCTION One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs.SUBUNIT The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells. Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1.INTERACTION Localized with DDX1 in cleavage bodies.ALTERNATIVE PRODUCTS Up-regulated during the G0 to S phase transition.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference
databaseName UniProt
dbId 72002
description
  • recommendedName: Cleavage stimulation factor subunit 2 alternativeName: CF-1 64 kDa subunit alternativeName: Cleavage stimulation factor 64 kDa subunit shortName: CSTF 64 kDa subunit shortName: CstF-64
displayName UniProt:P33240 CSTF2
geneName
  • CSTF2
identifier P33240
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Disease variant
  • Intellectual disability
  • Isopeptide bond
  • Methylation
  • mRNA processing
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • RNA-binding
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • CSTF2
otherIdentifier
  • 11722402_a_at
  • 11759641_at
  • 1478
  • 17105347
  • 204459_PM_at
  • 204459_at
  • 238821_PM_at
  • 238821_at
  • 3984540
  • 3984541
  • 3984542
  • 3984543
  • 3984544
  • 3984545
  • 3984547
  • 3984548
  • 3984549
  • 3984552
  • 3984553
  • 3984554
  • 3984555
  • 3984556
  • 3984557
  • 3984559
  • 3984560
  • 3984561
  • 3984562
  • 3984563
  • 3984564
  • 3984565
  • 3984567
  • 3984569
  • 3984570
  • 3984571
  • 3984572
  • 3984573
  • 3984574
  • 40334_at
  • 74305_at
  • 8168762
  • A_23_P148372
  • GE62616
  • GO:0003676
  • GO:0003723
  • GO:0003729
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005847
  • GO:0006397
  • GO:0016071
  • GO:0016604
  • GO:0031124
  • GO:0071920
  • GO:1990090
  • HMNXSV003009323
  • HMNXSV003047998
  • Hs.128578.0.A1_3p_at
  • ILMN_1653129
  • M85085_at
  • PH_hs_0025238
  • TC0X000470.hg
  • g4557492_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CSTF2_HUMAN
  • Q5H951
  • Q6LA74
  • Q8N502
sequenceLength 577
species [Species:48887] Homo sapiens
stId uniprot:P33240
url http://purl.uniprot.org/uniprot/P33240
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