Reactome | UniProt:P33076 CIITA

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UniProt:P33076 CIITA Show undefined attributes

chain	chain:1-1130
checksum	D698094576546509
comment	FUNCTION Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893, PubMed:40608405). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215).FUNCTION Exhibits dominant-negative suppression of MHC class II gene expression.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts with ZXDA and ZXDC (PubMed:17493635). Interacts with PML (isoform PML-2) (PubMed:23007646). Interacts with TAF7; interaction inhibits CIITA acetyltransferase activity, thereby repressing transcription (PubMed:20937824).SUBUNIT (Microbial infection) Interacts with human cytomegalovirus protein US28; this interaction decreases host HLA class II expression.INTERACTION Recruited to PML body by PML.ALTERNATIVE PRODUCTS The acetyltransferase domain is necessary for activation of both class I and class II transcription.DOMAIN The GTP-binding motif doesn't confer GTPase activity but promotes nuclear localization.PTM Autophosphorylated, affecting interaction with TAF7.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION CIITA mutation db
crossReference	[DatabaseIdentifier:12374301] RefSeq:NP_001366262.1 [DatabaseIdentifier:12374299] RefSeq:NP_001273332.1 [DatabaseIdentifier:12374300] RefSeq:NP_000237.2 [DatabaseIdentifier:12374298] RefSeq:XP_047290078.1 [DatabaseIdentifier:12287240] Pharos - Targets:P33076 [DatabaseIdentifier:12267701] PRO:P33076 [DatabaseIdentifier:12134847] Orphanet:CIITA [DatabaseIdentifier:12126996] OpenTargets:ENSG00000179583 [DatabaseIdentifier:11842404] HPA:ENSG00000179583-CIITA [DatabaseIdentifier:11804994] GlyGen:P33076 [DatabaseIdentifier:11789376] GeneCards:CIITA [DatabaseIdentifier:11778691] Guide to Pharmacology - Targets:1767 [DatabaseIdentifier:11696547] ENSEMBL:ENST00000381835 [DatabaseIdentifier:11573848] ENSEMBL:ENSP00000371257 [DatabaseIdentifier:11474908] ENSEMBL:ENSG00000179583
databaseName	UniProt
dbId	51086
description	recommendedName: fullName evidence="23"MHC class II transactivator shortName evidence="23"CIITA ecNumber evidence="5"2.3.1.- ecNumber evidence="14"2.7.11.1
displayName	UniProt:P33076 CIITA
geneName	CIITA MHC2TA
identifier	P33076
isSequenceChanged	false
keyword	Activator Acyltransferase Alternative splicing ATP-binding Disease variant GTP-binding Kinase Leucine-rich repeat Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat SCID Transcription Transcription regulation Transferase
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	CIITA
otherIdentifier	11743900_at 11752297_x_at 11753193_a_at 11760716_at 16815828 16815852 205101_PM_at 205101_at 210925_PM_at 210925_at 211884_PM_s_at 211884_s_at 238376_PM_at 238376_at 35616_at 3647994 3647995 3647996 3647999 3648000 3648001 3648002 3648003 3648007 3648008 3648009 3648010 3648012 3648014 3648015 3648016 3648017 3648018 3648020 3648022 3648023 3648024 3648026 3648027 3648028 3648029 3648030 3648031 3648032 3648033 3648034 3648035 3648036 3648037 3648038 3648039 3648040 3648041 3648042 3648043 3648044 3648045 3648046 3648047 3648048 3648049 3648050 3648051 3648052 3648054 3648055 3648056 3648057 3648058 3648060 3648062 3648063 3648064 3648065 3648066 3648067 3648068 3648070 3648071 3648072 41511_at 4261 70390_r_at 77028_at 7993195 83562_at 88987_at 88989_at ADDON000351.hg ADDON001927.hg A_14_P113685 A_14_P124936 A_14_P134819 A_14_P200414 A_23_P33384 A_23_P353478 A_24_P229936 A_24_P923807 A_32_P164971 A_32_P209960 A_33_P3233070 A_33_P3324394 GE684645 GO:0000122 GO:0000166 GO:0002376 GO:0003713 GO:0003714 GO:0003824 GO:0004674 GO:0005515 GO:0005524 GO:0005525 GO:0005634 GO:0005654 GO:0005829 GO:0006355 GO:0006955 GO:0016301 GO:0016605 GO:0016740 GO:0016746 GO:0032966 GO:0034341 GO:0042826 GO:0044877 GO:0045345 GO:0045348 GO:0045892 GO:0045944 GO:0046597 GO:0046677 GO:0060333 GO:0061629 GO:0106310 GO:0140096 GO:0140297 HMNXSV003018840 HMNXSV003025370 HMNXSV003051975 Hs.169738.0.S1_3p_at ILMN_1773363 PH_hs_0022395 PH_hs_0038422 PH_hs_0039914 TC16000158.hg TC16001411.hg TC16001412.hg U18259_at U18288_at X74301_s_at g1143159_3p_a_at g1143159_3p_x_at g4557748_3p_at g836910_3p_at p26711 p6281
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1031702] CIITA [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12739607] UCSC:P33076 CIITA [ReferenceDNASequence:12111919] OMIM:600005 CIITA [ReferenceDNASequence:12054109] NCBI Gene:4261 CIITA [ReferenceDNASequence:11970016] Monarch:4261 CIITA [ReferenceDNASequence:11881036] KEGG:hsa:4261 CIITA [ReferenceDNASequence:11821033] HGNC:7067 CIITA [ReferenceDNASequence:11436892] dbSNP Gene:4261 CIITA [ReferenceDNASequence:11416023] CTD Gene:4261 CIITA [ReferenceDNASequence:11399853] COSMIC - genes:CIITA CIITA [ReferenceDNASequence:11340227] BioGPS Gene:4261 CIITA [ReferenceDNASequence:ensembl:ENSG00000179583] ENSEMBL:ENSG00000179583 CIITA
referenceTranscript	[ReferenceRNASequence:12556086] RefSeq:XM_047434122.1 CIITA [ReferenceRNASequence:12556083] RefSeq:NM_001379333.1 CIITA [ReferenceRNASequence:12556084] RefSeq:NM_000246.4 CIITA [ReferenceRNASequence:12556085] RefSeq:NM_001286403.2 CIITA
schemaClass	ReferenceGeneProduct
secondaryIdentifier	C2TA_HUMAN A0A0B4J1S1 A0N0N9 D3DUG0 E9PFE0 Q29675 Q8SNB8 Q96KL4
sequenceLength	1130
species	[Species:48887] Homo sapiens
stId	uniprot:P33076
url	http://purl.uniprot.org/uniprot/P33076

Referrals

(interactor)	[UndirectedInteraction:11261323] UniProt:P33076 <-> UniProt:P98168 (IntAct) [UndirectedInteraction:11261319] UniProt:P33076 <-> UniProt:Q2QGD7 (IntAct) [UndirectedInteraction:11241091] UniProt:Q96EB6 <-> UniProt:P33076 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-1031702] CIITA [nucleoplasm]

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