UniProt:P32883 Kras

chain
  • chain:1-186
  • initiator methionine:1
  • chain:2-186
  • propeptide:187-189
checksum 97345422E01D2C81
comment
  • FUNCTION Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:1352876, PubMed:6474169). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)ACTIVITY REGULATION Alternates between an inactive form bound to GDP and an active form bound to GTP (By similarity). Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP) (By similarity). Interaction with SOS1 promotes exchange of bound GDP to GTP (By similarity).SUBUNIT Interacts with PHLPP (By similarity). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (By similarity). Interacts with SOS1 (By similarity). Interacts (when farnesylated) with GPR31 (By similarity). Interacts with RAP1GDS1 (By similarity). Interacts (active GTP-bound form) with both SHOC2 and PP1c (all isoforms) to form a tertiary complex; SHOC2 and PP1c preferably bind M-Ras/MRAS, but they also bind K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS (By similarity). Interacts (GTP-bound form) with MAPKAP1/SIN1; inhibiting K-Ras/KRAS activity (By similarity).SUBUNIT Interacts (when farnesylated) with GPR31.INTERACTION Isoforms differ in the C-terminal region which is encoded by two alternative exons (IVA and IVB).PTM Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).PTM Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.PTM Palmitoylated at Lys-182, Lys-184 and Lys-185. Lysine-depalmitoylation by SIRT2 promotes its localization to endomembranes in endocytic pathways.MISCELLANEOUS This gene is amplified in the mouse adrenal tumor Y1 cells, and is also directly linked to lung tumor susceptibility.SIMILARITY Belongs to the small GTPase superfamily. Ras family.
crossReference
databaseName UniProt
dbId 99638
description
  • recommendedName: GTPase KRas ecNumber evidence="2"3.6.5.2 alternativeName: K-Ras 2 alternativeName: Ki-Ras alternativeName: c-K-ras alternativeName: c-Ki-ras component recommendedName: GTPase KRas, N-terminally processed /component
displayName UniProt:P32883 Kras
geneName
  • Kras
  • Kras2
identifier P32883
isSequenceChanged false
keyword
  • Acetylation
  • Alternative splicing
  • Cell membrane
  • Cytoplasm
  • GTP-binding
  • Hydrolase
  • Isopeptide bond
  • Lipoprotein
  • Membrane
  • Methylation
  • Nucleotide-binding
  • Palmitate
  • Prenylation
  • Proto-oncogene
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • Kras
otherIdentifier
  • 10549256
  • 106672_at
  • 106938_at
  • 1426229_s_at
  • 1434000_at
  • 1441442_at
  • 1451979_at
  • 16653
  • 17472725
  • 4313059
  • 4335609
  • 4412753
  • 4441411
  • 4489978
  • 4570800
  • 4607066
  • 4802038
  • 4827993
  • 4926216
  • 5193962
  • 5260598
  • 5311146
  • 5431855
  • 5473122
  • 97991_at
  • A_51_P136233
  • A_51_P377237
  • A_51_P509489
  • A_55_P2008591
  • GE32892
  • GO:0000166
  • GO:0001889
  • GO:0003924
  • GO:0003925
  • GO:0005515
  • GO:0005525
  • GO:0005737
  • GO:0005886
  • GO:0007165
  • GO:0007265
  • GO:0007565
  • GO:0008283
  • GO:0008542
  • GO:0009629
  • GO:0009898
  • GO:0010467
  • GO:0010628
  • GO:0012505
  • GO:0014009
  • GO:0016020
  • GO:0016601
  • GO:0016787
  • GO:0019002
  • GO:0019003
  • GO:0019221
  • GO:0021897
  • GO:0022414
  • GO:0030036
  • GO:0030154
  • GO:0030275
  • GO:0030857
  • GO:0032228
  • GO:0035022
  • GO:0035900
  • GO:0035914
  • GO:0043495
  • GO:0043524
  • GO:0044877
  • GO:0048009
  • GO:0048169
  • GO:0048856
  • GO:0048873
  • GO:0051146
  • GO:0051384
  • GO:0051385
  • GO:0051402
  • GO:0051450
  • GO:0060038
  • GO:0060090
  • GO:0060252
  • GO:0060441
  • GO:0060509
  • GO:0098772
  • GO:2000774
  • ILMN_2773211
  • mMC023531
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RASK_MOUSE
  • P04200
  • P08643
sequenceLength 189
species [Species:48892] Mus musculus
stId uniprot:P32883
url http://purl.uniprot.org/uniprot/P32883

Referrals

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