Reactome | UniProt:P32833 ORC2

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UniProt:P32833 ORC2 Show undefined attributes

chain	chain:1-620
checksum	486E3E5CE353807F
comment	FUNCTION Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.SUBUNIT Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with MCM10 and TAH11.INTERACTION Present with 1700 molecules/cell in log phase SD medium.SIMILARITY Belongs to the ORC2 family.
crossReference	[DatabaseIdentifier:12435123] RefSeq:NP_009616.1 [DatabaseIdentifier:12256226] PRO:P32833 [DatabaseIdentifier:12141985] PDB:9BCX [DatabaseIdentifier:12142007] PDB:5ZR1 [DatabaseIdentifier:12141995] PDB:8ZP5 [DatabaseIdentifier:12141990] PDB:5V8F [DatabaseIdentifier:12141996] PDB:7TJH [DatabaseIdentifier:12141993] PDB:8ZP4 [DatabaseIdentifier:12142002] PDB:7TJJ [DatabaseIdentifier:12141999] PDB:6WGC [DatabaseIdentifier:12142000] PDB:7TJK [DatabaseIdentifier:12141989] PDB:7MCA [DatabaseIdentifier:12141997] PDB:9GJW [DatabaseIdentifier:12142003] PDB:9GM5 [DatabaseIdentifier:12141991] PDB:6WGG [DatabaseIdentifier:12142004] PDB:9GJP [DatabaseIdentifier:12141998] PDB:7TJF [DatabaseIdentifier:12141992] PDB:6WGI [DatabaseIdentifier:12141987] PDB:8ZPK [DatabaseIdentifier:12142001] PDB:7TJI [DatabaseIdentifier:12142006] PDB:6RQC [DatabaseIdentifier:11737122] ENSEMBL:YBR060C_mRNA [DatabaseIdentifier:11614423] ENSEMBL:YBR060C [DatabaseIdentifier:11503046] ENSEMBL:YBR060C
databaseName	UniProt
dbId	97394
description	recommendedName: Origin recognition complex subunit 2 alternativeName: Origin recognition complex 71 kDa subunit
displayName	UniProt:P32833 ORC2
geneName	ORC2 RRR1 SIR5 YBR060C YBR0523
identifier	P32833
isSequenceChanged	false
keyword	3D-structure Direct protein sequencing DNA replication Nucleus Phosphoprotein Reference proteome
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	ORC2
otherIdentifier	852352 GO:0000781 GO:0000808 GO:0003674 GO:0003682 GO:0003688 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005656 GO:0005664 GO:0006260 GO:0006267 GO:0006270 GO:0006325 GO:0006348 GO:0008150 GO:0030466 GO:0031261 GO:0031509 GO:0051568
physicalEntity	[EntityWithAccessionedSequence:R-SCE-9749316] yORC2 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-68405] ORC2 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12704395] UCSC:P32833 ORC2 [ReferenceDNASequence:12082519] NCBI Gene:852352 ORC2 [ReferenceDNASequence:11998426] Monarch:852352 ORC2 [ReferenceDNASequence:11906882] KEGG:sce:YBR060C ORC2 [ReferenceDNASequence:11368637] BioGPS Gene:852352 ORC2
referenceTranscript	[ReferenceRNASequence:12616627] RefSeq:NM_001178408.1 ORC2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ORC2_YEAST D6VQ60
sequenceLength	620
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P32833
url	http://purl.uniprot.org/uniprot/P32833

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