Reactome | UniProt:P32456 GBP2

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UniProt:P32456 GBP2 Show undefined attributes

chain	chain:1-588 propeptide:589-591
checksum	B09B3C2F3C3E1EA2
comment	FUNCTION Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:31091448).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)BIOPHYSICOCHEMICAL PROPERTIES Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures (PubMed:21151871). Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5 (PubMed:21151871).INTERACTION GBP2-GBP5 dimers localize to the Golgi apparatus.INDUCTION By IFNG/IFN-gamma during macrophage activation, and by TNF and IL1B.PTM (Microbial infection) Ubiquitinated by S.flexneri IpaH9.8, leading to its degradation by the proteasome, thereby preventing its ability to promote host defense against bacterial infection.PTM Isoprenylation is required for proper subcellular location.SIMILARITY Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
crossReference	[DatabaseIdentifier:12432931] RefSeq:NP_004111.2 [DatabaseIdentifier:12292433] Pharos - Targets:P32456 [DatabaseIdentifier:12254739] PRO:P32456 [DatabaseIdentifier:12223444] PDB:7E58 [DatabaseIdentifier:12223442] PDB:7M1S [DatabaseIdentifier:12223443] PDB:6VKJ [DatabaseIdentifier:12132263] OpenTargets:ENSG00000162645 [DatabaseIdentifier:11847580] HPA:ENSG00000162645-GBP2 [DatabaseIdentifier:11831713] HMDB Protein:HMDBP08415 [DatabaseIdentifier:11794611] GeneCards:GBP2 [DatabaseIdentifier:11735831] ENSEMBL:ENST00000464839 [DatabaseIdentifier:11735832] ENSEMBL:ENST00000370466 [DatabaseIdentifier:11613132] ENSEMBL:ENSP00000359497 [DatabaseIdentifier:11613133] ENSEMBL:ENSP00000434282 [DatabaseIdentifier:11502211] ENSEMBL:ENSG00000162645
databaseName	UniProt
dbId	55452
description	recommendedName: Guanylate-binding protein 2 ecNumber evidence="14"3.6.5.- alternativeName: fullName evidence="17"GTP-binding protein 2 shortName evidence="17"GBP-2 shortName: HuGBP-2 alternativeName: fullName evidence="17"Guanine nucleotide-binding protein 2 alternativeName: Interferon-induced guanylate-binding protein 2
displayName	UniProt:P32456 GBP2
geneName	GBP2
identifier	P32456
isSequenceChanged	false
keyword	3D-structure Antimicrobial Cytoplasm Cytoplasmic vesicle Golgi apparatus GTP-binding Hydrolase Immunity Innate immunity Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	GBP2
otherIdentifier	11719447_s_at 11762406_s_at 16689352 16689354 202748_PM_at 202748_at 2345791 2421897 2421906 2421922 2421923 2421924 2421926 2421927 2421928 2421929 2421930 2421931 2421932 2421933 2421934 2421935 2421936 2421937 2421939 2421940 2421941 2421945 2421947 2421948 2421949 2421950 2421951 2421952 2421953 2421954 2421955 2421956 2421957 2421958 2421959 2421967 2421968 2421970 2421971 2421972 242907_PM_at 242907_at 2634 3261927 32700_at 3458061 3458065 3458073 3458076 3458078 7917528 7917530 7917532 7964250 81887_at 83245_at A_23_P85693 A_24_P263623 A_24_P36898 GE57976 GE857395 GE86699 GO:0000139 GO:0000166 GO:0002218 GO:0002376 GO:0003924 GO:0004866 GO:0005515 GO:0005525 GO:0005634 GO:0005654 GO:0005737 GO:0005794 GO:0005829 GO:0006955 GO:0016020 GO:0016787 GO:0030659 GO:0031410 GO:0034504 GO:0042742 GO:0042802 GO:0042803 GO:0042832 GO:0045087 GO:0046718 GO:0048471 GO:0050830 GO:0051604 GO:0051607 GO:0051715 GO:0071222 GO:0071346 GO:0071347 GO:0071356 GO:0098542 GO:0098772 GO:0140639 GO:0140678 GO:0140973 HMNXSV003039761 Hs.160628.0.A1_3p_at ILMN_1690137 ILMN_1774077 M55543_at PH_hs_0013512 PH_hs_0018787 TC01006361.hg g6996011_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9955197] K48polyUb-GBP2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9947851] GGC-C588-GBP2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1015673] GBP2 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12704003] UCSC:P32456 GBP2 [ReferenceDNASequence:12116640] OMIM:600412 GBP2 [ReferenceDNASequence:12081439] NCBI Gene:2634 GBP2 [ReferenceDNASequence:11997346] Monarch:2634 GBP2 [ReferenceDNASequence:11905897] KEGG:hsa:2634 GBP2 [ReferenceDNASequence:11826306] HGNC:4183 GBP2 [ReferenceDNASequence:11430923] dbSNP Gene:2634 GBP2 [ReferenceDNASequence:11423405] CTD Gene:2634 GBP2 [ReferenceDNASequence:11394810] COSMIC - genes:GBP2 GBP2 [ReferenceDNASequence:11367557] BioGPS Gene:2634 GBP2 [ReferenceDNASequence:ensembl:ENSG00000162645] ENSEMBL:ENSG00000162645 GBP2
referenceTranscript	[ReferenceRNASequence:12614411] RefSeq:NM_004120.4 GBP2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GBP2_HUMAN Q6GPH0 Q6IAU2 Q86TB0
sequenceLength	591
species	[Species:48887] Homo sapiens
stId	uniprot:P32456
url	http://purl.uniprot.org/uniprot/P32456

Referrals

(interactor)	[UndirectedInteraction:11250633] UniProt:P32456 <-> UniProt:Q96PP9 (IntAct) [UndirectedInteraction:11250631] UniProt:P32456 <-> UniProt:Q9WMX2-PRO_0000037548 (IntAct) [UndirectedInteraction:11250629] UniProt:P32456 <-> UniProt:P08238 (IntAct) [UndirectedInteraction:11250627] UniProt:P32456 <-> UniProt:Q8N8V2 (IntAct) [UndirectedInteraction:11250625] UniProt:P32456 <-> UniProt:Q58FG0 (IntAct) [UndirectedInteraction:11250623] UniProt:P32456 <-> UniProt:P32456 (IntAct) [UndirectedInteraction:11250623] UniProt:P32456 <-> UniProt:P32456 (IntAct) [UndirectedInteraction:11250621] UniProt:P32456 <-> UniProt:Q9H0R5 (IntAct) [UndirectedInteraction:11171811] UniProt:Q96PP8 <-> UniProt:P32456 (IntAct) [UndirectedInteraction:11171015] UniProt:P32455 <-> UniProt:P32456 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9955197] K48polyUb-GBP2 [cytosol] [EntityWithAccessionedSequence:R-HSA-9947851] GGC-C588-GBP2 [cytosol] [EntityWithAccessionedSequence:R-HSA-1015673] GBP2 [cytosol]
(referenceSequence)	[GroupModifiedResidue:9955158] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position [GroupModifiedResidue:9947858] S-geranylgeranyl-L-cysteine (geranylgeranyl group) at 588