Reactome | UniProt:P31949 S100A11

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UniProt:P31949 S100A11 Show undefined attributes

chain	chain:1-105 initiator methionine:1 chain:2-105
checksum	1729ED680290CFE4
comment	FUNCTION Facilitates the differentiation and the cornification of keratinocytes.SUBUNIT Homodimer; disulfide-linked.INTERACTION Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.MISCELLANEOUS Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.SIMILARITY Belongs to the S-100 family.
crossReference	[DatabaseIdentifier:12399255] RefSeq:NP_005611.1 [DatabaseIdentifier:12280755] Pharos - Targets:P31949 [DatabaseIdentifier:12237907] PRO:P31949 [DatabaseIdentifier:12148465] PDB:1V50 [DatabaseIdentifier:12148466] PDB:1V4Z [DatabaseIdentifier:12148467] PDB:2LUC [DatabaseIdentifier:12120419] OpenTargets:ENSG00000163191 [DatabaseIdentifier:11835954] HPA:ENSG00000163191-S100A11 [DatabaseIdentifier:11830361] HMDB Protein:HMDBP07985 [DatabaseIdentifier:11798505] GlyGen:P31949 [DatabaseIdentifier:11782842] GeneCards:S100A11 [DatabaseIdentifier:11779948] Guide to Pharmacology - Targets:3083 [DatabaseIdentifier:11712685] ENSEMBL:ENST00000271638 [DatabaseIdentifier:11589986] ENSEMBL:ENSP00000271638 [DatabaseIdentifier:11486168] ENSEMBL:ENSG00000163191
databaseName	UniProt
dbId	63932
description	recommendedName: Protein S100-A11 alternativeName: Calgizzarin alternativeName: Metastatic lymph node gene 70 protein shortName: MLN 70 alternativeName: Protein S100-C alternativeName: S100 calcium-binding protein A11 component recommendedName: Protein S100-A11, N-terminally processed /component
displayName	UniProt:P31949 S100A11
geneName	S100A11 MLN70 S100C
identifier	P31949
isSequenceChanged	false
keyword	3D-structure Acetylation Calcium Cytoplasm Direct protein sequencing Disulfide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	S100A11
otherIdentifier	11744033_s_at 16693280 200660_PM_at 200660_at 2435411 2435412 2435413 2435414 2435416 2435417 2435420 2996871 38138_at 6282 7920128 A_23_P126593 D38583_at GE522371 GE86862 GO:0001726 GO:0005509 GO:0005515 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005912 GO:0007165 GO:0008156 GO:0008285 GO:0014911 GO:0034774 GO:0042127 GO:0042803 GO:0044548 GO:0046872 GO:0048306 GO:0070062 GO:0098609 GO:0098641 HMNXSV003008435 ILMN_1750101 PH_hs_0019645 PH_hs_0035936 TC01003240.hg g5032056_3p_at g5032056_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6804808] S100A11 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6804784] S100A11 [secretory granule lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12696202] UCSC:P31949 S100A11 [ReferenceDNASequence:12106231] OMIM:603114 S100A11 [ReferenceDNASequence:12065360] NCBI Gene:6282 S100A11 [ReferenceDNASequence:11981267] Monarch:6282 S100A11 [ReferenceDNASequence:11891237] KEGG:hsa:6282 S100A11 [ReferenceDNASequence:11814450] HGNC:10488 S100A11 [ReferenceDNASequence:11429766] dbSNP Gene:6282 S100A11 [ReferenceDNASequence:11406355] CTD Gene:6282 S100A11 [ReferenceDNASequence:11393771] COSMIC - genes:S100A11 S100A11 [ReferenceDNASequence:11351478] BioGPS Gene:6282 S100A11 [ReferenceDNASequence:ensembl:ENSG00000163191] ENSEMBL:ENSG00000163191 S100A11
referenceTranscript	[ReferenceRNASequence:12580966] RefSeq:NM_005620.2 S100A11
schemaClass	ReferenceGeneProduct
secondaryIdentifier	S10AB_HUMAN Q5VTK0
sequenceLength	105
species	[Species:48887] Homo sapiens
stId	uniprot:P31949
url	http://purl.uniprot.org/uniprot/P31949

Referrals

(interactor)	[UndirectedInteraction:11272245] UniProt:P15336 <-> UniProt:P31949 (IntAct) [UndirectedInteraction:11211489] UniProt:P01375 <-> UniProt:P31949 (IntAct) [UndirectedInteraction:11200373] UniProt:P04637 <-> UniProt:P31949 (IntAct) [UndirectedInteraction:11140727] UniProt:P04271 <-> UniProt:P31949 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6804808] S100A11 [extracellular region] [EntityWithAccessionedSequence:R-HSA-6804784] S100A11 [secretory granule lumen]

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