Reactome | UniProt:P30939 HTR1F

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UniProt:P30939 HTR1F Show undefined attributes

chain	chain:1-366
checksum	16EA80344793B54F
comment	FUNCTION G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:21422162, PubMed:34239069, PubMed:8380639, PubMed:8384716). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:21422162, PubMed:8380639, PubMed:8384716). Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed:34239069). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:34239069). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:34239069, PubMed:35610220).SUBCELLULAR LOCATION Belongs to the G-protein coupled receptor 1 family.
crossReference	[DatabaseIdentifier:12818529] ZINC - World Drugs:5HT1F_HUMAN [DatabaseIdentifier:12814744] ZINC target:P30939 [DatabaseIdentifier:12811426] ZINC - Substances:5HT1F_HUMAN [DatabaseIdentifier:12809078] ZINC - Predictions - Purchasable:5HT1F_HUMAN [DatabaseIdentifier:12807611] ZINC - Metabolites:5HT1F_HUMAN [DatabaseIdentifier:12805896] ZINC - FDA approved:5HT1F_HUMAN [DatabaseIdentifier:12804816] ZINC - Biogenic:5HT1F_HUMAN [DatabaseIdentifier:12440385] RefSeq:XP_054202388.1 [DatabaseIdentifier:12440390] RefSeq:NP_000857.1 [DatabaseIdentifier:12440383] RefSeq:XP_054202387.1 [DatabaseIdentifier:12440389] RefSeq:XP_011531966.1 [DatabaseIdentifier:12440384] RefSeq:XP_005264808.1 [DatabaseIdentifier:12440387] RefSeq:NP_001309138.1 [DatabaseIdentifier:12440388] RefSeq:NP_001309137.1 [DatabaseIdentifier:12440386] RefSeq:NP_001309139.1 [DatabaseIdentifier:12280337] Pharos - Targets:P30939 [DatabaseIdentifier:12258541] PRO:P30939 [DatabaseIdentifier:12145954] PDB:7EXD [DatabaseIdentifier:12119997] OpenTargets:ENSG00000179097 [DatabaseIdentifier:11835540] HPA:ENSG00000179097-HTR1F [DatabaseIdentifier:11829877] HMDB Protein:HMDBP02464 [DatabaseIdentifier:11798102] GlyGen:P30939 [DatabaseIdentifier:11782422] GeneCards:HTR1F [DatabaseIdentifier:11779551] Guide to Pharmacology - Targets:5 [DatabaseIdentifier:11740823] ENSEMBL:ENST00000319595 [DatabaseIdentifier:11618124] ENSEMBL:ENSP00000322924 [DatabaseIdentifier:11505458] ENSEMBL:ENSG00000179097
databaseName	UniProt
dbId	49172
description	recommendedName: fullName evidence="10"5-hydroxytryptamine receptor 1F shortName evidence="10"5-HT-1F shortName evidence="10"5-HT1F alternativeName: fullName evidence="10"Serotonin receptor 1F
displayName	UniProt:P30939 HTR1F
geneName	HTR1F HTR1EL
identifier	P30939
isSequenceChanged	false
keyword	3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	HTR1F
otherIdentifier	11740561_at 16942919 221458_PM_at 221458_at 2631941 2631942 2631943 2631945 2631974 2631975 2631976 2631977 2631978 2631979 3355 8081067 A_14_P123815 A_23_P166674 A_33_P3406836 GE80212 GO:0001586 GO:0004930 GO:0004993 GO:0005886 GO:0007165 GO:0007186 GO:0007187 GO:0007189 GO:0007193 GO:0007198 GO:0007268 GO:0016020 GO:0030425 GO:0030594 GO:0045202 GO:0051378 GO:0099589 HMNXSV003039377 HMNXSV003040602 ILMN_1685285 L05597_at PH_hs_0013159 TC03000463.hg g10835196_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-390979] HTR1F [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12705871] UCSC:P30939 HTR1F [ReferenceDNASequence:12105848] OMIM:182134 HTR1F [ReferenceDNASequence:12084800] NCBI Gene:3355 HTR1F [ReferenceDNASequence:12000707] Monarch:3355 HTR1F [ReferenceDNASequence:11909003] KEGG:hsa:3355 HTR1F [ReferenceDNASequence:11814028] HGNC:5292 HTR1F [ReferenceDNASequence:11431328] dbSNP Gene:3355 HTR1F [ReferenceDNASequence:11405788] CTD Gene:3355 HTR1F [ReferenceDNASequence:11395151] COSMIC - genes:HTR1F HTR1F [ReferenceDNASequence:11370918] BioGPS Gene:3355 HTR1F [ReferenceDNASequence:ensembl:ENSG00000179097] ENSEMBL:ENSG00000179097 HTR1F
referenceTranscript	[ReferenceRNASequence:12621892] RefSeq:NM_001322209.2 HTR1F [ReferenceRNASequence:12621896] RefSeq:XM_005264751.4 HTR1F [ReferenceRNASequence:12621895] RefSeq:XM_011533664.3 HTR1F [ReferenceRNASequence:12621893] RefSeq:NM_001322208.2 HTR1F [ReferenceRNASequence:12621891] RefSeq:NM_001322210.2 HTR1F [ReferenceRNASequence:12621894] RefSeq:NM_000866.5 HTR1F [ReferenceRNASequence:12621889] RefSeq:XM_054346412.1 HTR1F [ReferenceRNASequence:12621890] RefSeq:XM_054346413.1 HTR1F
schemaClass	ReferenceGeneProduct
secondaryIdentifier	5HT1F_HUMAN
sequenceLength	366
species	[Species:48887] Homo sapiens
stId	uniprot:P30939
url	http://purl.uniprot.org/uniprot/P30939

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(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-390979] HTR1F [plasma membrane]

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