Reactome | UniProt:P30740 SERPINB1

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UniProt:P30740 SERPINB1 Show undefined attributes

chain	chain:1-379
checksum	BAAE08DFCBCD8CD3
comment	FUNCTION Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).SUBUNIT Monomer (PubMed:23269243). Interacts (via C-terminus) with CASP1; CASP4 (via CARD domain) and CASP5; these interactions regulate the activity of inflammatory caspases (PubMed:30692621). Interacts with PRTN3 (PubMed:30692621). Interacts with GZMH (PubMed:23269243).SUBCELLULAR LOCATION In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes.DOMAIN Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin, chymase or granzyme H, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophil elastase, proteinase-3, pancreatic elastase or PSA.SIMILARITY Belongs to the serpin family. Ov-serpin subfamily.
crossReference	[DatabaseIdentifier:12281515] Pharos - Targets:P30740 [DatabaseIdentifier:12259481] PRO:P30740 [DatabaseIdentifier:12121184] OpenTargets:ENSG00000021355 [DatabaseIdentifier:11836706] HPA:ENSG00000021355-SERPINB1 [DatabaseIdentifier:11799151] GlyGen:P30740 [DatabaseIdentifier:11742979] ENSEMBL:ENST00000380739 [DatabaseIdentifier:11620280] ENSEMBL:ENSP00000370115 [DatabaseIdentifier:11506859] ENSEMBL:ENSG00000021355
databaseName	UniProt
dbId	57297
description	recommendedName: Leukocyte elastase inhibitor shortName: LEI alternativeName: Monocyte/neutrophil elastase inhibitor shortName: EI shortName: M/NEI alternativeName: Peptidase inhibitor 2 shortName: PI-2 alternativeName: Serpin B1
displayName	UniProt:P30740 SERPINB1
geneName	SERPINB1 ELANH2 MNEI PI2
identifier	P30740
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Endosome Lysosome Phosphoprotein Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor
modified	[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType	Protein
name	SERPINB1
otherIdentifier	11748280_a_at 17015084 1992 212268_PM_at 212268_at 213572_PM_s_at 213572_s_at 228726_PM_at 228726_at 2938983 2938984 2938985 2938986 2938987 2938988 2938989 2938990 2938991 2938992 2938993 2938994 2938995 2938996 2938997 2938998 2938999 2939000 2939001 2939004 2939005 2939006 2939007 2939008 2939009 2939010 2939011 33305_at 8123598 A_23_P214330 A_24_P269315 GE61239 GO:0004867 GO:0005515 GO:0005576 GO:0005615 GO:0005737 GO:0005764 GO:0005768 GO:0005769 GO:0010951 GO:0016020 GO:0030312 GO:0030336 GO:0030414 GO:0031012 GO:0032691 GO:0034774 GO:0036464 GO:0043226 GO:0044194 GO:0044342 GO:0051246 GO:0070062 GO:0098772 HMNXSV003007794 Hs.183583.0.S1_3p_a_at Hs.183583.0.S1_3p_x_at Hs.183583.1.S1_3p_a_at Hs.234392.2.A1_3p_at ILMN_1679133 M93056_at PH_hs_0024336 TC06001217.hg TC06003341.hg TC06003342.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6804818] SERPINB1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6804786] SERPINB1 [secretory granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8962908] SERPINB1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12706855] UCSC:P30740 SERPINB1 [ReferenceDNASequence:11815216] HGNC:3311 SERPINB1 [ReferenceDNASequence:11395294] COSMIC - genes:SERPINB1 SERPINB1 [ReferenceDNASequence:ensembl:ENSG00000021355] ENSEMBL:ENSG00000021355 SERPINB1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ILEU_HUMAN A8K5L2 B4DNT0 Q53FB9 Q5W0E1 Q9UDF8
sequenceLength	379
species	[Species:48887] Homo sapiens
stId	uniprot:P30740
url	http://purl.uniprot.org/uniprot/P30740

Referrals

(interactor)	[UndirectedInteraction:11134819] UniProt:P30740 <-> UniProt:Q15915 (IntAct) [UndirectedInteraction:11134817] UniProt:P30740 <-> UniProt:Q9NU19 (IntAct) [UndirectedInteraction:11134813] UniProt:P30740 <-> UniProt:Q00403 (IntAct) [UndirectedInteraction:11134811] UniProt:P30740 <-> UniProt:P48431 (IntAct) [UndirectedInteraction:11134809] UniProt:P30740 <-> UniProt:Q9BTV5 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6804818] SERPINB1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-6804786] SERPINB1 [secretory granule lumen] [EntityWithAccessionedSequence:R-HSA-8962908] SERPINB1 [cytosol]