UniProt:P30550 GRPR

chain
  • chain:1-384
checksum 70A75F11D9C82F19
comment
  • FUNCTION Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).SUBCELLULAR LOCATION Highly expressed in pancreas (PubMed:11245983). Also expressed in stomach, adrenal cortex and brain (PubMed:11245983). In brain, expressed in cells throughout the cortex (PubMed:34610277).SIMILARITY Belongs to the G-protein coupled receptor 1 family.
crossReference
databaseName UniProt
dbId 55968
description
  • recommendedName: Gastrin-releasing peptide receptor shortName: GRP-R alternativeName: GRP-preferring bombesin receptor
displayName UniProt:P30550 GRPR
geneName
  • GRPR
identifier P30550
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Disulfide bond
  • G-protein coupled receptor
  • Glycoprotein
  • Lipoprotein
  • Membrane
  • Palmitate
  • Phosphoprotein
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Transducer
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • GRPR
otherIdentifier
  • 11740435_at
  • 11740436_at
  • 17101775
  • 207929_PM_at
  • 207929_at
  • 2925
  • 32430_at
  • 3970025
  • 3970026
  • 3970032
  • 3970033
  • 3970034
  • 3970035
  • 8166202
  • A_14_P201775
  • A_23_P62255
  • A_24_P357266
  • GE58058
  • GO:0004930
  • GO:0005886
  • GO:0007165
  • GO:0007186
  • GO:0007200
  • GO:0007218
  • GO:0007611
  • GO:0008188
  • GO:0008528
  • GO:0016020
  • GO:0035176
  • GO:0036343
  • GO:0042127
  • GO:0042923
  • GO:0043207
  • GO:0050877
  • GO:0061744
  • GO:1903942
  • GO:2000987
  • HMNXSV003026399
  • ILMN_1813851
  • ILMN_2119123
  • M73481_at
  • PH_hs_0004223
  • TC0X000073.hg
  • g4885360_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GRPR_HUMAN
  • B2R910
sequenceLength 384
species [Species:48887] Homo sapiens
stId uniprot:P30550
url http://purl.uniprot.org/uniprot/P30550
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