FUNCTION Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.FUNCTION Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.CATALYTIC ACTIVITY heme b + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = biliverdin IXalpha + CO + Fe(2+) + 3 oxidized [NADPH--hemoprotein reductase] + 3 H2O + H(+)ACTIVITY REGULATION Inhibited by metalloporphyrins such as Sn- and Zn-protoporphyrins.INTERACTION A soluble form arises by proteolytic removal of the membrane anchor.PTM S-nitrosylated by BLVRB.SIMILARITY Belongs to the heme oxygenase family.
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