Reactome | UniProt:P30050 RPL12

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UniProt:P30050 RPL12 Show undefined attributes

chain	chain:1-165
checksum	7EFD783A8ED350F9
comment	FUNCTION Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680).SUBUNIT Component of the large ribosomal subunit (PubMed:23636399, PubMed:25901680). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:23636399, PubMed:25901680). The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S) (PubMed:23636399, PubMed:25901680). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:23636399, PubMed:25901680).INTERACTION Ubiquitinated at Lys-48 and Lys-83 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).SIMILARITY Belongs to the universal ribosomal protein uL11 family.
crossReference	[DatabaseIdentifier:12148686] PDB:9B0P [DatabaseIdentifier:12339720] RefSeq:NP_000967.1 [DatabaseIdentifier:12291306] Pharos - Targets:P30050 [DatabaseIdentifier:12253275] PRO:P30050 [DatabaseIdentifier:12145983] PDB:8FKT [DatabaseIdentifier:12139130] PDB:8FL4 [DatabaseIdentifier:12145985] PDB:8FKR [DatabaseIdentifier:12145826] PDB:8IDY [DatabaseIdentifier:12217582] PDB:7VB2 [DatabaseIdentifier:12148741] PDB:9AZS [DatabaseIdentifier:12144887] PDB:8IR1 [DatabaseIdentifier:12139132] PDB:8FL3 [DatabaseIdentifier:12144885] PDB:8FL0 [DatabaseIdentifier:12145980] PDB:8FKZ [DatabaseIdentifier:12148937] PDB:8IDT [DatabaseIdentifier:12145982] PDB:8FKS [DatabaseIdentifier:12148737] PDB:6ZM7 [DatabaseIdentifier:12144891] PDB:9QIW [DatabaseIdentifier:12144886] PDB:8IR3 [DatabaseIdentifier:12139131] PDB:8FL2 [DatabaseIdentifier:12148661] PDB:8UJK [DatabaseIdentifier:12148691] PDB:8UIY [DatabaseIdentifier:12148943] PDB:9GY4 [DatabaseIdentifier:12145979] PDB:8FKY [DatabaseIdentifier:12148718] PDB:9AZC [DatabaseIdentifier:12148664] PDB:8UJJ [DatabaseIdentifier:12148782] PDB:8YOP [DatabaseIdentifier:12148697] PDB:4V6X [DatabaseIdentifier:12144890] PDB:8RL2 [DatabaseIdentifier:12148680] PDB:9B0R [DatabaseIdentifier:12148676] PDB:8UJB [DatabaseIdentifier:12145976] PDB:8FL6 [DatabaseIdentifier:12148715] PDB:9AZN [DatabaseIdentifier:12144892] PDB:8IPD [DatabaseIdentifier:12168176] PDB:5A8L [DatabaseIdentifier:12144883] PDB:8IPX [DatabaseIdentifier:12145977] PDB:8FKV [DatabaseIdentifier:12148777] PDB:5AJ0 [DatabaseIdentifier:12148927] PDB:8FLC [DatabaseIdentifier:12146422] PDB:6ZMO [DatabaseIdentifier:12148694] PDB:9B0J [DatabaseIdentifier:12145969] PDB:8FLA [DatabaseIdentifier:12148703] PDB:8UKB [DatabaseIdentifier:12148708] PDB:8G6J [DatabaseIdentifier:12145974] PDB:8FKX [DatabaseIdentifier:12145975] PDB:8FKU [DatabaseIdentifier:12145825] PDB:8INF [DatabaseIdentifier:12148683] PDB:9B0O [DatabaseIdentifier:12148671] PDB:6OLG [DatabaseIdentifier:12148688] PDB:8UIZ [DatabaseIdentifier:12148668] PDB:9B0W [DatabaseIdentifier:12148672] PDB:8G5Z [DatabaseIdentifier:11459770] ENSEMBL:ENSG00000197958 [DatabaseIdentifier:11552298] ENSEMBL:ENSP00000441179 [DatabaseIdentifier:11552299] ENSEMBL:ENSP00000354739 [DatabaseIdentifier:11674997] ENSEMBL:ENST00000536368 [DatabaseIdentifier:11674998] ENSEMBL:ENST00000361436 [DatabaseIdentifier:11793463] GeneCards:RPL12 [DatabaseIdentifier:11809439] GlyGen:P30050 [DatabaseIdentifier:11846452] HPA:ENSG00000197958-RPL12 [DatabaseIdentifier:12131111] OpenTargets:ENSG00000197958 [DatabaseIdentifier:12148684] PDB:8G60 [DatabaseIdentifier:12145972] PDB:8FLB [DatabaseIdentifier:12148785] PDB:8YOO [DatabaseIdentifier:12148793] PDB:9B0F [DatabaseIdentifier:12146421] PDB:6ZMI [DatabaseIdentifier:12145973] PDB:8FKW [DatabaseIdentifier:12148757] PDB:8XSY [DatabaseIdentifier:12148770] PDB:8K2C [DatabaseIdentifier:12148698] PDB:9B0N [DatabaseIdentifier:12148690] PDB:9B0S [DatabaseIdentifier:12145968] PDB:8INE [DatabaseIdentifier:12148679] PDB:9B0Q [DatabaseIdentifier:12144889] PDB:8INK [DatabaseIdentifier:12148759] PDB:8XSZ [DatabaseIdentifier:12148761] PDB:8XSX [DatabaseIdentifier:12148945] PDB:8FL9 [DatabaseIdentifier:12148730] PDB:6ZME [DatabaseIdentifier:12148687] PDB:9B11 [DatabaseIdentifier:12144882] PDB:8IPY [DatabaseIdentifier:12148695] PDB:9B0G [DatabaseIdentifier:12148689] PDB:8UJ9 [DatabaseIdentifier:12145978] PDB:8FL7 [DatabaseIdentifier:12148696] PDB:9B0H
databaseName	UniProt
dbId	72407
description	recommendedName: fullName evidence="5"Large ribosomal subunit protein uL11 alternativeName: 60S ribosomal protein L12
displayName	UniProt:P30050 RPL12
geneName	RPL12
identifier	P30050
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein RNA-binding Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	RPL12
otherIdentifier	11757134_at 11757659_x_at 17098491 17098504 17117849 200088_PM_x_at 200088_x_at 200809_PM_x_at 200809_x_at 214271_PM_x_at 214271_x_at 2523629 2523630 2523631 2523632 2573790 2596922 3225931 3225932 3225933 3225934 3225935 3225936 3225937 3225938 3225939 3225940 3225941 3225942 3225943 3225944 3225945 3225946 3225947 3249580 33668_at 3560707 3560710 3765291 3765293 3852122 3889927 3889928 3889929 3889930 3889931 3899886 6136 69376_at 7894321 7894774 7895112 7895317 8047635 8063473 8125750 8164210 8164215 A_23_P217068 A_23_P358240 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005515 GO:0005737 GO:0005829 GO:0005840 GO:0005925 GO:0006412 GO:0014069 GO:0016020 GO:0022625 GO:0022626 GO:0043226 GO:0070062 GO:0070180 GO:1990904 HMNXSV003019488 HMNXSV003055279 Hs.182979.1.A1_3p_a_at Hs.182979.1.A1_3p_x_at Hs.182979.2.S1_3p_at ILMN_1653469 ILMN_1787326 ILMN_2116366 L06505_at PH_hs_0030078 PH_hs_0039111 RNA33459\|snoRNA_scaRNA_55_137 TC09001601.hg TC09001602.hg g4506596_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-72408] RPL12 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000197958] ENSEMBL:ENSG00000197958 RPL12 [ReferenceDNASequence:12678105] UCSC:P30050 RPL12 [ReferenceDNASequence:11324464] BioGPS Gene:6136 RPL12 [ReferenceDNASequence:11391801] COSMIC - genes:RPL12 RPL12 [ReferenceDNASequence:11421920] CTD Gene:6136 RPL12 [ReferenceDNASequence:11427505] dbSNP Gene:6136 RPL12 [ReferenceDNASequence:11825154] HGNC:10302 RPL12 [ReferenceDNASequence:11866958] KEGG:hsa:6136 RPL12 [ReferenceDNASequence:11954253] Monarch:6136 RPL12 [ReferenceDNASequence:12038346] NCBI Gene:6136 RPL12 [ReferenceDNASequence:12115602] OMIM:180475 RPL12
referenceTranscript	[ReferenceRNASequence:12521614] RefSeq:NM_000976.4 RPL12
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RL12_HUMAN Q5VVV2 Q6PB27
sequenceLength	165
species	[Species:48887] Homo sapiens
stId	uniprot:P30050
url	http://purl.uniprot.org/uniprot/P30050

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-72408] RPL12 [cytosol]
(interactor)	[UndirectedInteraction:11149301] UniProt:P13569 <-> UniProt:P30050 (IntAct) [UndirectedInteraction:11218647] UniProt:P10636-8 <-> UniProt:P30050 (IntAct) [UndirectedInteraction:11299531] UniProt:P27824 <-> UniProt:P30050 (IntAct) [UndirectedInteraction:11305493] UniProt:Q5S007 <-> UniProt:P30050 (IntAct)

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