UniProt:P29972 AQP1

chain
  • initiator methionine:1
  • chain:2-269
checksum BA204D82FB26352E
comment
  • FUNCTION Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053).CATALYTIC ACTIVITY H2O(in) = H2O(out)CATALYTIC ACTIVITY nitric oxide(out) = nitric oxide(in)CATALYTIC ACTIVITY CO2(out) = CO2(in)CATALYTIC ACTIVITY glycerol(in) = glycerol(out)CATALYTIC ACTIVITY H2O2(out) = H2O2(in)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)ACTIVITY REGULATION The water channel activity is inhibited by P-choloromercuribenzene sulphonate and diethylpyrocarbonate(DPPC) (PubMed:8584435). The glycerol channel activity is inhibited by P-choloromercuribenzene sulphonate, diethylpyrocarbonate(DPPC), phloretin and Cu(2+) (PubMed:8584435). Inhibited by mercury (PubMed:7677994).SUBUNIT Homotetramer; each monomer provides an independent water pore (PubMed:11171962, PubMed:35835865). Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1 (PubMed:35835865). Interacts with EPHB2; involved in endolymph production in the inner ear (By similarity). Identified in a complex with STOM (PubMed:23219802). Interacts (via the N-terminal) with ANK1 (via ANK 1-5 repeats) (PubMed:35835865). Interacts (via the C-terminal) with EPB42 (PubMed:35835865).INTERACTION Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.DOMAIN Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).POLYMORPHISM AQP1 is responsible for the Colton blood group system [MIM:110450]. Approximately 92% of Caucasians are Co(A+B-) (Ala-45), approximately 8% are Co(A+B+), and only 0.2% are Co(A-B+) (Val-45). Co(A-B-) which is very rare, is due to a complete absence of AQP1.SIMILARITY Belongs to the MIP/aquaporin (TC 1.A.8) family.ONLINE INFORMATION Liquid states - Issue 36 of July 2003
crossReference
databaseName UniProt
dbId 50176
description
  • recommendedName: fullName evidence="23"Aquaporin-1 shortName: AQP-1 alternativeName: Aquaporin-CHIP alternativeName: fullName evidence="22"Channel-like integral membrane protein of 28 kDa alternativeName: Urine water channel
displayName UniProt:P29972 AQP1
geneName
  • AQP1
  • CHIP28
identifier P29972
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Blood group antigen
  • Cell membrane
  • Direct protein sequencing
  • Glycoprotein
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • AQP1
otherIdentifier
  • 11715941_s_at
  • 11715942_a_at
  • 11747177_x_at
  • 11756045_s_at
  • 17044862
  • 207542_PM_s_at
  • 207542_s_at
  • 209047_PM_at
  • 209047_at
  • 2995590
  • 2995591
  • 2995593
  • 2995594
  • 2995595
  • 2995596
  • 2995597
  • 2995598
  • 358
  • 36156_at
  • 8132118
  • A_14_P131012
  • A_23_P19894
  • A_33_P3253723
  • GE59145
  • GO:0003014
  • GO:0003091
  • GO:0003094
  • GO:0003097
  • GO:0005223
  • GO:0005267
  • GO:0005372
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005886
  • GO:0005901
  • GO:0005903
  • GO:0006813
  • GO:0006833
  • GO:0006884
  • GO:0006972
  • GO:0007010
  • GO:0007163
  • GO:0008519
  • GO:0009925
  • GO:0009992
  • GO:0010761
  • GO:0010763
  • GO:0015079
  • GO:0015168
  • GO:0015250
  • GO:0015267
  • GO:0015670
  • GO:0015793
  • GO:0016020
  • GO:0016323
  • GO:0016324
  • GO:0016477
  • GO:0019233
  • GO:0019725
  • GO:0019934
  • GO:0021670
  • GO:0022600
  • GO:0022857
  • GO:0030157
  • GO:0030184
  • GO:0030185
  • GO:0030424
  • GO:0030950
  • GO:0031526
  • GO:0031965
  • GO:0032940
  • GO:0033326
  • GO:0033363
  • GO:0034644
  • GO:0035377
  • GO:0035378
  • GO:0035379
  • GO:0042060
  • GO:0042383
  • GO:0042476
  • GO:0042802
  • GO:0043066
  • GO:0044241
  • GO:0045177
  • GO:0045766
  • GO:0046875
  • GO:0046878
  • GO:0048146
  • GO:0048593
  • GO:0048856
  • GO:0048870
  • GO:0050829
  • GO:0050877
  • GO:0050891
  • GO:0051458
  • GO:0051649
  • GO:0055085
  • GO:0070062
  • GO:0070295
  • GO:0070301
  • GO:0071260
  • GO:0071280
  • GO:0071288
  • GO:0071300
  • GO:0071320
  • GO:0071456
  • GO:0071472
  • GO:0071474
  • GO:0071549
  • GO:0071732
  • GO:0071805
  • GO:0072220
  • GO:0072230
  • GO:0072232
  • GO:0072239
  • GO:0072488
  • GO:0080170
  • GO:0098542
  • GO:0098655
  • GO:0140070
  • GO:0170014
  • HMNXSV003011575
  • Hs.74602.1.S2_3p_at
  • ILMN_1681103
  • ILMN_1776857
  • M77829_s_at
  • PH_hs_0028973
  • TC07002236.hg
  • U41518_at
  • g4755121_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AQP1_HUMAN
  • B5BU39
  • E7EM69
  • E9PC21
  • F5GY19
  • Q8TBI5
  • Q8TDC1
sequenceLength 269
species [Species:48887] Homo sapiens
stId uniprot:P29972
url http://purl.uniprot.org/uniprot/P29972
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