UniProt:P29310 14-3-3zeta

chain
  • chain:1-248
checksum C645CF3B10C6701A
comment
  • FUNCTION Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development (PubMed:9159395). Acts upstream of Raf and downstream of Ras, and is essential for viability (PubMed:9159395). Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob (PubMed:10230800). Inhibits yki activity by restricting its nuclear localization (PubMed:19900439). Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes (PubMed:27015288).SUBUNIT Homodimer; homodimerization is not essential for modulating the activity of Slo (PubMed:12529354). Interacts with phosphorylated Slob; the interaction with Slob mediates an indirect interaction with Slo (PubMed:10230800). Interacts with phosphorylated yki (PubMed:18256197, PubMed:19900439). Interacts with hemo; this represses 14-3-3zeta activity which prevents the 14-3-3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing (PubMed:27015288). Interacts with REPTOR (when phosphorylated), this interaction may assist the cytoplasmic retention of REPTOR (PubMed:25920570).INTERACTION Predominantly expressed in the ventral nerve cord of the embryo, and in the neural tissues of the head. Also found in the region posterior to the morphogenetic furrow of the eye imaginal disk where cells differentiate as photoreceptors.DEVELOPMENTAL STAGE Expressed throughout all stages of embryonic and larval development.SIMILARITY Belongs to the 14-3-3 family.
crossReference
databaseName UniProt
dbId 84085
description
  • recommendedName: 14-3-3 protein zeta alternativeName: 14-3-3-like protein alternativeName: Protein Leonardo
displayName UniProt:P29310 14-3-3zeta
geneName
  • 14-3-3zeta
  • 14-3-3
  • 14-3-3EZ
  • leo
  • THAP
  • CG17870
identifier P29310
isSequenceChanged false
keyword
  • Alternative splicing
  • Cytoplasm
  • Developmental protein
  • Differentiation
  • Endosome
  • Neurogenesis
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • 14-3-3zeta
otherIdentifier
  • 153924_at
  • 1625148_s_at
  • 36059
  • GO:0000278
  • GO:0001223
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005739
  • GO:0005768
  • GO:0005769
  • GO:0005829
  • GO:0005886
  • GO:0006457
  • GO:0007059
  • GO:0007165
  • GO:0007294
  • GO:0007399
  • GO:0007460
  • GO:0007611
  • GO:0008103
  • GO:0008104
  • GO:0016020
  • GO:0016301
  • GO:0030154
  • GO:0031965
  • GO:0035332
  • GO:0040040
  • GO:0042803
  • GO:0045172
  • GO:0045448
  • GO:0046579
  • GO:0046982
  • GO:0048856
  • GO:0050821
  • GO:0050877
  • GO:0051220
  • GO:0120176
  • GO:0140313
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • 1433Z_DROME
  • A4UZB2
  • A4UZB3
  • C1C593
  • C9QP27
  • O01665
  • Q0E9D5
  • Q0E9D6
  • Q0E9D7
  • Q8IGB9
  • Q8MKV5
  • Q9V5G6
sequenceLength 248
species [Species:56210] Drosophila melanogaster
stId uniprot:P29310
url http://purl.uniprot.org/uniprot/P29310
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