UniProt:P29074 PTPN4

chain
  • chain:1-926
checksum 4DAC6A87A675CFB0
comment
  • FUNCTION Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Also dephosphorylates the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton.CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateSUBUNIT Interacts with MAPK12 (via C-terminus); this interaction abolishes PTPN4 catalytic autoinhibition and thus activates the phosphatase activity.SUBUNIT (Microbial infection) Interacts with attenuated rabies virus protein G; this interaction is required for virally-induced apoptosis.INTERACTION Highly phosphorylated on serine and threonine residues but not on tyrosines.PTM Cleaved and activated by calpain I/CAPN1.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
crossReference
databaseName UniProt
dbId 62429
description
  • recommendedName: Tyrosine-protein phosphatase non-receptor type 4 ecNumber: 3.1.3.48 alternativeName: Protein-tyrosine phosphatase MEG1 shortName: MEG shortName: PTPase-MEG1
displayName UniProt:P29074 PTPN4
geneName
  • PTPN4
identifier P29074
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Cytoplasm
  • Cytoskeleton
  • Hydrolase
  • Membrane
  • Phosphoprotein
  • Protein phosphatase
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • PTPN4
otherIdentifier
  • 11741358_a_at
  • 1459_at
  • 1460_g_at
  • 16885041
  • 205171_PM_at
  • 205171_at
  • 230230_PM_at
  • 230230_at
  • 232161_3p_x_at
  • 232161_PM_x_at
  • 232161_x_at
  • 236935_PM_at
  • 236935_at
  • 2503022
  • 2503023
  • 2503024
  • 2503025
  • 2503026
  • 2503027
  • 2503028
  • 2503029
  • 2503030
  • 2503038
  • 2503042
  • 2503045
  • 2503046
  • 2503049
  • 2503050
  • 2503051
  • 2503052
  • 2503059
  • 2503065
  • 2503066
  • 2503068
  • 2503070
  • 2503071
  • 2503072
  • 2503073
  • 2503075
  • 2503076
  • 2503077
  • 2503078
  • 2503080
  • 2503081
  • 2503082
  • 2503083
  • 2503084
  • 2503085
  • 2503086
  • 2503088
  • 2503089
  • 2503092
  • 2503093
  • 2503097
  • 2503099
  • 2503100
  • 2503101
  • 2503102
  • 2503103
  • 2503104
  • 2503106
  • 2503108
  • 42078_at
  • 45455_at
  • 47847_at
  • 5775
  • 70407_at
  • 75626_at
  • 8044849
  • A_14_P119145
  • A_23_P165343
  • A_24_P122940
  • A_32_P183983
  • A_32_P96845
  • A_33_P3265920
  • GE532907
  • GE58049
  • GE87878
  • GO:0003824
  • GO:0004721
  • GO:0004725
  • GO:0004726
  • GO:0005515
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0005856
  • GO:0005886
  • GO:0006470
  • GO:0008092
  • GO:0009898
  • GO:0016020
  • GO:0016311
  • GO:0016787
  • GO:0035254
  • GO:0140096
  • HMNXSV003016275
  • Hs.145934.0.A1_3p_at
  • Hs.26743.0.A1_3p_at
  • Hs.71592.0.S1_3p_at
  • Hs.71592.0.S1_3p_x_at
  • ILMN_1793549
  • M68941_at
  • PH_hs_0023771
  • TC02000756.hg
  • TC02003533.hg
  • g4506294_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PTN4_HUMAN
  • B2RBV8
  • Q9UDA7
sequenceLength 926
species [Species:48887] Homo sapiens
stId uniprot:P29074
url http://purl.uniprot.org/uniprot/P29074
Cite Us!