UniProt:P28562 DUSP1

chain
  • chain:1-367
checksum 11BD1D39A9FCD51F
comment
  • FUNCTION Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphateINTERACTION Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.INDUCTION By oxidative stress and heat shock.PTM Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.PTM 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
crossReference
databaseName UniProt
dbId 53956
description
  • recommendedName: fullName evidence="12"Dual specificity protein phosphatase 1 ecNumber evidence="1"3.1.3.16 ecNumber evidence="6"3.1.3.48 alternativeName: fullName evidence="11"Dual specificity protein phosphatase hVH1 alternativeName: Mitogen-activated protein kinase phosphatase 1 shortName: MAP kinase phosphatase 1 shortName: MKP-1 alternativeName: fullName evidence="10"Protein-tyrosine phosphatase CL100
displayName UniProt:P28562 DUSP1
geneName
  • DUSP1
  • CL100
  • MKP1
  • PTPN10
  • VH1
identifier P28562
isSequenceChanged false
keyword
  • 3D-structure
  • Cell cycle
  • Hydrolase
  • Nucleus
  • Phosphoprotein
  • Protein phosphatase
  • Proteomics identification
  • Reference proteome
  • Stress response
  • Ubl conjugation
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • DUSP1
otherIdentifier
  • 1005_at
  • 11715765_a_at
  • 11715766_a_at
  • 11752993_a_at
  • 11758730_x_at
  • 17002846
  • 1843
  • 201041_PM_s_at
  • 201041_s_at
  • 201044_PM_x_at
  • 201044_x_at
  • 2887308
  • 2887310
  • 2887311
  • 2887312
  • 2887314
  • 2887315
  • 2887316
  • 2887318
  • 2887320
  • 2887321
  • 8115831
  • A_23_P110712
  • GE61271
  • GO:0001706
  • GO:0003824
  • GO:0004721
  • GO:0004722
  • GO:0004725
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0006470
  • GO:0007162
  • GO:0007165
  • GO:0008138
  • GO:0008285
  • GO:0009416
  • GO:0016311
  • GO:0016787
  • GO:0017017
  • GO:0019838
  • GO:0032355
  • GO:0032526
  • GO:0032870
  • GO:0033574
  • GO:0035335
  • GO:0035556
  • GO:0035970
  • GO:0042542
  • GO:0043065
  • GO:0043066
  • GO:0043407
  • GO:0043409
  • GO:0051019
  • GO:0051384
  • GO:0051447
  • GO:0051591
  • GO:0051592
  • GO:0070262
  • GO:0070371
  • GO:0070373
  • GO:0090027
  • GO:0090266
  • GO:0140096
  • GO:1903753
  • GO:1990869
  • GO:2000279
  • HMNXSV003055852
  • Hs.171695.0.A1_3p_a_at
  • ILMN_1781285
  • PH_hs_0010276
  • TC05002066.hg
  • X68277_at
  • g7108342_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DUS1_HUMAN
  • D3DQL9
  • Q2V508
sequenceLength 367
species [Species:48887] Homo sapiens
stId uniprot:P28562
url http://purl.uniprot.org/uniprot/P28562
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