UniProt:P28336 NMBR

chain
  • chain:1-390
checksum 8BA9AAD4F3B7309F
comment
  • FUNCTION Receptor for neuromedin-B (PubMed:1655761). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).SUBCELLULAR LOCATION Expressed in epididymis (at protein level).INDUCTION Up-regulated in response to infection with influenza A virus.SIMILARITY Belongs to the G-protein coupled receptor 1 family.
crossReference
databaseName UniProt
dbId 60291
description
  • recommendedName: Neuromedin-B receptor shortName: NMB-R alternativeName: Epididymis tissue protein Li 185a alternativeName: Neuromedin-B-preferring bombesin receptor
displayName UniProt:P28336 NMBR
geneName
  • NMBR
identifier P28336
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Disulfide bond
  • G-protein coupled receptor
  • Glycoprotein
  • Lipoprotein
  • Membrane
  • Palmitate
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Transducer
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9862192] Weiser, Joel, 2024-02-26
moleculeType Protein
name
  • NMBR
otherIdentifier
  • 11736983_at
  • 17024317
  • 207333_PM_at
  • 207333_at
  • 2977123
  • 2977125
  • 2977126
  • 2977127
  • 2977128
  • 2977129
  • 2977130
  • 2977131
  • 2977132
  • 2977133
  • 2977134
  • 2977140
  • 33996_at
  • 4829
  • 80477_at
  • 8129947
  • A_23_P70634
  • GE531954
  • GO:0004930
  • GO:0004946
  • GO:0005829
  • GO:0005886
  • GO:0007165
  • GO:0007186
  • GO:0007200
  • GO:0007218
  • GO:0008188
  • GO:0008528
  • GO:0016020
  • GO:0031989
  • GO:0032715
  • GO:0032727
  • GO:0090290
  • GO:0140374
  • GO:0160023
  • GO:1903942
  • HMNXSV003033744
  • ILMN_1735704
  • M73482_at
  • PH_hs_0025990
  • TC06002177.hg
  • TC06002178.hg
  • g4505406_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NMBR_HUMAN
  • E9KL38
  • Q5VUK8
sequenceLength 390
species [Species:48887] Homo sapiens
stId uniprot:P28336
url http://purl.uniprot.org/uniprot/P28336
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