UniProt:P27930 IL1R2

chain
  • signal peptide:1-13
  • chain:14-398
  • chain:14-
checksum 2C2A03ADA6F3AC5B
comment
  • FUNCTION Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.SUBUNIT Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.INTERACTION A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.SIMILARITY Belongs to the interleukin-1 receptor family.
crossReference
databaseName UniProt
dbId 57242
description
  • recommendedName: Interleukin-1 receptor type 2 shortName: IL-1R-2 shortName: IL-1RT-2 shortName: IL-1RT2 alternativeName: CD121 antigen-like family member B alternativeName: CDw121b alternativeName: IL-1 type II receptor alternativeName: Interleukin-1 receptor beta shortName: IL-1R-beta alternativeName: Interleukin-1 receptor type II cdAntigenNameCD121b/cdAntigenName component recommendedName: Interleukin-1 receptor type 2, membrane form shortName: mIL-1R2 shortName: mIL-1RII /component component recommendedName: Interleukin-1 receptor type 2, soluble form shortName: sIL-1R2 shortName: sIL-1RII /component
displayName UniProt:P27930 IL1R2
geneName
  • IL1R2
  • IL1RB
identifier P27930
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin domain
  • Membrane
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • IL1R2
otherIdentifier
  • 11728500_a_at
  • 16883624
  • 205403_PM_at
  • 205403_at
  • 211372_PM_s_at
  • 211372_s_at
  • 2496908
  • 2496911
  • 2496912
  • 2496914
  • 2496915
  • 2496917
  • 2496918
  • 2496919
  • 2496920
  • 2496921
  • 2496922
  • 2496923
  • 2496925
  • 2496927
  • 2496928
  • 2496929
  • 2496931
  • 2496932
  • 2496933
  • 2496934
  • 2496936
  • 2496937
  • 2496938
  • 2496940
  • 2496941
  • 2496942
  • 7850
  • 8043981
  • 998_s_at
  • A_23_P79398
  • A_24_P63019
  • GE59851
  • GO:0002376
  • GO:0004908
  • GO:0004910
  • GO:0005515
  • GO:0005576
  • GO:0005737
  • GO:0005886
  • GO:0006955
  • GO:0007166
  • GO:0009986
  • GO:0010955
  • GO:0016020
  • GO:0016485
  • GO:0019221
  • GO:0019966
  • GO:0032690
  • GO:1900016
  • GO:2000660
  • HMNXSV003047779
  • HMNXSV003048623
  • ILMN_1758371
  • ILMN_1772131
  • ILMN_2251766
  • PH_hs_0002227
  • TC02000619.hg
  • X59770_at
  • g1488065_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IL1R2_HUMAN
  • D3DVJ5
  • Q6LCE6
  • Q9UE68
sequenceLength 398
species [Species:48887] Homo sapiens
stId uniprot:P27930
url http://purl.uniprot.org/uniprot/P27930

Referrals

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