Reactome | UniProt:P26678 PLN

Schema > ReferenceGeneProduct > Entries

UniProt:P26678 PLN Show undefined attributes

chain	chain:1-52
checksum	0766304A76A854D3
comment	FUNCTION Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (By similarity). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (By similarity).SUBUNIT Homopentamer (PubMed:16043693, PubMed:16897780). Can also form heterooligomers with other sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) regulators ARLN, ERLN, SLN and STRIT1/DWORF (PubMed:36523160). Monomer (By similarity). Interacts with HAX1 (PubMed:17241641). Interacts as a monomer with ATP2A2; the interaction decreases ATP2A2 Ca(2+) affinity (PubMed:28890335, PubMed:36523160). Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2 (PubMed:28890335). Interacts with S100A1 in a Ca(2+)-dependent manner (PubMed:12804600).INTERACTION Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK at the sarcoplasmic reticulum (PubMed:15598648).TISSUE SPECIFICITY Heart muscle (at protein level).PTM Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.PTM Palmitoylated by ZDHHC16, promoting formation of the homopentamer.PTM In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS For practical reasons, PLN activity is most often studied with ATP2A1 instead of ATP2A2.SIMILARITY Belongs to the phospholamban family.
crossReference	[DatabaseIdentifier:12413158] RefSeq:NP_002658.1 [DatabaseIdentifier:12285253] Pharos - Targets:P26678 [DatabaseIdentifier:12244912] PRO:P26678 [DatabaseIdentifier:12175808] PDB:7E0Z [DatabaseIdentifier:12175813] PDB:1ZLL [DatabaseIdentifier:12175812] PDB:2HYN [DatabaseIdentifier:12175809] PDB:1PLP [DatabaseIdentifier:12175811] PDB:7E12 [DatabaseIdentifier:12175810] PDB:7E11 [DatabaseIdentifier:12148072] PDB:6Y40 [DatabaseIdentifier:12136250] Orphanet:PLN [DatabaseIdentifier:12124945] OpenTargets:ENSG00000198523 [DatabaseIdentifier:11840408] HPA:ENSG00000198523-PLN [DatabaseIdentifier:11831366] HMDB Protein:HMDBP02625 [DatabaseIdentifier:11787335] GeneCards:PLN [DatabaseIdentifier:11722297] ENSEMBL:ENST00000357525 [DatabaseIdentifier:11599598] ENSEMBL:ENSP00000350132 [DatabaseIdentifier:11492420] ENSEMBL:ENSG00000198523
databaseName	UniProt
dbId	62062
description	recommendedName: fullName evidence="19 21"Phospholamban shortName: PLB
displayName	UniProt:P26678 PLN
geneName	PLN PLB
identifier	P26678
isSequenceChanged	false
keyword	3D-structure Acetylation Cardiomyopathy Disease variant Endoplasmic reticulum Lipoprotein Membrane Mitochondrion Palmitate Phosphoprotein Proteomics identification Reference proteome Sarcoplasmic reticulum Transmembrane Transmembrane helix
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	PLN
otherIdentifier	11723644_a_at 11723645_at 11764124_s_at 17012100 204938_PM_s_at 204938_s_at 204939_PM_s_at 204939_s_at 204940_PM_at 204940_at 228202_PM_at 228202_at 2923271 2923273 2923274 2923275 2923276 2923277 2923278 2923279 2923280 2923281 2923283 2923285 2923287 38734_at 5350 8121729 87826_s_at 89608_r_at A_14_P201133 A_23_P30614 A_24_P414803 A_32_P213418 GE470744 GE58027 GO:0001675 GO:0002026 GO:0003012 GO:0003013 GO:0003015 GO:0004857 GO:0005515 GO:0005739 GO:0005783 GO:0005789 GO:0006816 GO:0006874 GO:0007219 GO:0007283 GO:0008015 GO:0008016 GO:0008542 GO:0010043 GO:0010459 GO:0010880 GO:0010881 GO:0016020 GO:0016529 GO:0022414 GO:0031966 GO:0031982 GO:0032868 GO:0032991 GO:0033017 GO:0033574 GO:0042030 GO:0042802 GO:0042803 GO:0043226 GO:0044325 GO:0045475 GO:0045822 GO:0046716 GO:0048471 GO:0048738 GO:0048856 GO:0050802 GO:0051117 GO:0051480 GO:0051924 GO:0051926 GO:0055119 GO:0086004 GO:0086023 GO:0086036 GO:0086092 GO:0090279 GO:0090281 GO:0090534 GO:0098772 GO:0141110 GO:1901077 GO:1901894 GO:1901895 GO:1901897 GO:1902081 GO:1990629 HMNXSV003027943 Hs.85050.1.A1_3p_at ILMN_1730811 ILMN_2192245 M63603_at PH_hs_0037401 TC06000935.hg TC06003017.hg g190018_3p_a_at g4505886_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5578813] p-S16-PLN [sarcoplasmic reticulum membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5490319] PLN [sarcoplasmic reticulum membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12698425] UCSC:P26678 PLN [ReferenceDNASequence:12110307] OMIM:172405 PLN [ReferenceDNASequence:12071821] NCBI Gene:5350 PLN [ReferenceDNASequence:11987728] Monarch:5350 PLN [ReferenceDNASequence:11897246] KEGG:hsa:5350 PLN [ReferenceDNASequence:11818974] HGNC:9080 PLN [ReferenceDNASequence:11430183] dbSNP Gene:5350 PLN [ReferenceDNASequence:11412985] CTD Gene:5350 PLN [ReferenceDNASequence:11394138] COSMIC - genes:PLN PLN [ReferenceDNASequence:11357939] BioGPS Gene:5350 PLN [ReferenceDNASequence:ensembl:ENSG00000198523] ENSEMBL:ENSG00000198523 PLN
referenceTranscript	[ReferenceRNASequence:12594851] RefSeq:NM_002667.5 PLN
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PPLA_HUMAN
sequenceLength	52
species	[Species:48887] Homo sapiens
stId	uniprot:P26678
url	http://purl.uniprot.org/uniprot/P26678

Referrals

(interactor)	[UndirectedInteraction:11297179] UniProt:Q92838 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11280605] UniProt:O60883 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11254565] UniProt:Q7Z5P4 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11250899] UniProt:Q8IWU4 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11246929] UniProt:O15342 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11232085] UniProt:Q16623 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11214157] UniProt:Q8N661 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11203193] UniProt:Q3SXY8 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11186923] UniProt:Q96BA8 <-> UniProt:P26678 (IntAct) [UndirectedInteraction:11180133] UniProt:Q9H2K0 <-> UniProt:P26678 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5578813] p-S16-PLN [sarcoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-5490319] PLN [sarcoplasmic reticulum membrane]
(referenceSequence)	[ModifiedResidue:5578781] O-phospho-L-serine at 16

Cite Us!