UniProt:P26196 DDX6

chain
  • chain:1-483
checksum F802C642861793FB
comment
  • FUNCTION Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT (Microbial infection) Interacts with rotavirus A non-structural protein 2; this interaction probably plays a role in the sequestration of DDX6 in viral factories (PubMed:30258011). Interacts with rotavirus A non-structural protein 5; this interaction probably plays a role in its sequestration in viral factories (PubMed:30258011).SUBUNIT Interacts with LSM14A, LSM14B, EIF4ENIF1/4E-T, PATL1, EDC3 and EDC4 (PubMed:26027925, PubMed:26489469, PubMed:27342281, PubMed:28216671, PubMed:29510985, PubMed:31422817, PubMed:31439631, PubMed:32354837). Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915, PubMed:19285948). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with RC3H1 (By similarity). Interacts with ATXN2L (PubMed:23209657). Interacts with MCRIP1 (PubMed:26184334). Interacts with MCRIP2 (PubMed:26184334). Interacts with NUFIP2 (PubMed:26184334). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361). Interacts with GIGYF1 and GIGYF2 (PubMed:31439631).INTERACTION Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:28216671). Upon cellular stress, relocalizes to stress granules (PubMed:26184334).TISSUE SPECIFICITY Abundantly expressed in most tissues.PTM Sumoylated (PubMed:26184334).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).SIMILARITY Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
crossReference
databaseName UniProt
dbId 53512
description
  • recommendedName: fullName evidence="24"Probable ATP-dependent RNA helicase DDX6 ecNumber evidence="25"3.6.4.13 alternativeName: ATP-dependent RNA helicase p54 alternativeName: DEAD box protein 6 alternativeName: Oncogene RCK
displayName UniProt:P26196 DDX6
geneName
  • DDX6
  • HLR2
  • RCK
identifier P26196
isSequenceChanged false
keyword
  • 3D-structure
  • ATP-binding
  • Chromosomal rearrangement
  • Cytoplasm
  • Disease variant
  • Helicase
  • Hydrolase
  • Intellectual disability
  • Nucleotide-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Proto-oncogene
  • Reference proteome
  • RNA-binding
  • Ubl conjugation
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • DDX6
otherIdentifier
  • 11718967_at
  • 11718968_a_at
  • 11718969_a_at
  • 1656
  • 16745085
  • 204909_PM_at
  • 204909_at
  • 225549_PM_at
  • 225549_at
  • 2947762
  • 2947768
  • 3393943
  • 3393945
  • 3393947
  • 3393948
  • 3393949
  • 3393950
  • 3393951
  • 3393952
  • 3393953
  • 3393954
  • 3393955
  • 3393956
  • 3393957
  • 3393959
  • 3393960
  • 3393961
  • 3393962
  • 3393963
  • 3393964
  • 3393970
  • 3393971
  • 3393972
  • 3393973
  • 3393974
  • 3393975
  • 3393976
  • 3393978
  • 3393979
  • 3393982
  • 3495819
  • 3495822
  • 36283_at
  • 52993_at
  • 70792_at
  • 7952103
  • A_23_P203201
  • A_24_P215407
  • D17532_at
  • GE57104
  • GE86447
  • GE86532
  • GO:0000166
  • GO:0000792
  • GO:0000932
  • GO:0001520
  • GO:0003676
  • GO:0003723
  • GO:0003724
  • GO:0003729
  • GO:0003824
  • GO:0004386
  • GO:0005515
  • GO:0005524
  • GO:0005634
  • GO:0005737
  • GO:0005786
  • GO:0005829
  • GO:0005886
  • GO:0005912
  • GO:0006617
  • GO:0007283
  • GO:0010494
  • GO:0016020
  • GO:0016442
  • GO:0016787
  • GO:0016887
  • GO:0017148
  • GO:0019074
  • GO:0019827
  • GO:0019904
  • GO:0022414
  • GO:0030154
  • GO:0030182
  • GO:0031047
  • GO:0033391
  • GO:0033962
  • GO:0034063
  • GO:0035278
  • GO:0036464
  • GO:0043226
  • GO:0045296
  • GO:0045665
  • GO:0048471
  • GO:0048515
  • GO:0061830
  • GO:0065003
  • GO:0097227
  • GO:0140098
  • GO:0140657
  • HMNXSV003003073
  • Hs.271541.0.S1_3p_at
  • ILMN_1777340
  • PH_hs_0023351
  • PH_hs_0032397
  • TC11002353.hg
  • TC11003376.hg
  • Z11685_s_at
  • g13514828_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DDX6_HUMAN
  • Q5D048
sequenceLength 483
species [Species:48887] Homo sapiens
stId uniprot:P26196
url http://purl.uniprot.org/uniprot/P26196

Referrals

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