Reactome | UniProt:P25774 CTSS

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UniProt:P25774 CTSS Show undefined attributes

chain	signal peptide:1-16 propeptide:17-114 chain:115-331
checksum	86093619DB6F0269
comment	FUNCTION Thiol protease (PubMed:30612035). Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (PubMed:30612035). Elicits itch by mediating cleavage and activation of MRGPRX1 (By similarity).CATALYTIC ACTIVITY Similar to cathepsin L, but with much less activity on Z-Phe-Arg-\|-NHMec, and more activity on the Z-Val-Val-Arg-\|-Xaa compound.SUBUNIT Monomer.SUBCELLULAR LOCATION Belongs to the peptidase C1 family.
crossReference	[DatabaseIdentifier:12188777] PDB:2R9O [DatabaseIdentifier:12818650] ZINC - World Drugs:CATS_HUMAN [DatabaseIdentifier:12817484] ZINC target:P25774 [DatabaseIdentifier:12814050] ZINC - Substances:CATS_HUMAN [DatabaseIdentifier:12810626] ZINC - Predictions - Purchasable:CATS_HUMAN [DatabaseIdentifier:12807083] ZINC - Investigational:CATS_HUMAN [DatabaseIdentifier:12805997] ZINC - FDA approved:CATS_HUMAN [DatabaseIdentifier:12461295] RefSeq:NP_001186668.1 [DatabaseIdentifier:12461296] RefSeq:NP_004070.3 [DatabaseIdentifier:12286987] Pharos - Targets:P25774 [DatabaseIdentifier:12267280] PRO:P25774 [DatabaseIdentifier:12188832] PDB:1MS6 [DatabaseIdentifier:12188831] PDB:2H7J [DatabaseIdentifier:12188806] PDB:5QC5 [DatabaseIdentifier:12188805] PDB:2OP3 [DatabaseIdentifier:12188801] PDB:5QC4 [DatabaseIdentifier:12188788] PDB:5QBW [DatabaseIdentifier:12188779] PDB:5QCB [DatabaseIdentifier:12188785] PDB:5QCC [DatabaseIdentifier:12188787] PDB:5QCE [DatabaseIdentifier:12188827] PDB:9GJ2 [DatabaseIdentifier:12188776] PDB:2G7Y [DatabaseIdentifier:12188781] PDB:3IEJ [DatabaseIdentifier:12188792] PDB:5QBY [DatabaseIdentifier:12188791] PDB:5QC7 [DatabaseIdentifier:12188778] PDB:2R9N [DatabaseIdentifier:12188809] PDB:6YYO [DatabaseIdentifier:12188837] PDB:2FYE [DatabaseIdentifier:12188816] PDB:2C0Y [DatabaseIdentifier:12188782] PDB:5QCA [DatabaseIdentifier:12188803] PDB:5QBU [DatabaseIdentifier:12188829] PDB:3N4C [DatabaseIdentifier:12188835] PDB:2G6D [DatabaseIdentifier:12188797] PDB:5QC0 [DatabaseIdentifier:12188810] PDB:6YYN [DatabaseIdentifier:12188820] PDB:8PI3 [DatabaseIdentifier:12188802] PDB:5QC3 [DatabaseIdentifier:12188818] PDB:3N3G [DatabaseIdentifier:12188821] PDB:5QCG [DatabaseIdentifier:12188784] PDB:5QCD [DatabaseIdentifier:12188786] PDB:5QCF [DatabaseIdentifier:12188823] PDB:5QCI [DatabaseIdentifier:12188819] PDB:5QCH [DatabaseIdentifier:12188825] PDB:2FQ9 [DatabaseIdentifier:12188800] PDB:2FRA [DatabaseIdentifier:12188812] PDB:6YYP [DatabaseIdentifier:12188815] PDB:3OVX [DatabaseIdentifier:12188804] PDB:5QC6 [DatabaseIdentifier:12188817] PDB:1GLO [DatabaseIdentifier:12188807] PDB:1NQC [DatabaseIdentifier:12188799] PDB:5QC1 [DatabaseIdentifier:12188808] PDB:2F1G [DatabaseIdentifier:12188814] PDB:6YYR [DatabaseIdentifier:12188826] PDB:2HHN [DatabaseIdentifier:12188793] PDB:5QBX [DatabaseIdentifier:12188783] PDB:2FRQ [DatabaseIdentifier:12188833] PDB:4P6E [DatabaseIdentifier:12188789] PDB:5QC8 [DatabaseIdentifier:11516450] ENSEMBL:ENSG00000163131 [DatabaseIdentifier:11633515] ENSEMBL:ENSP00000357981 [DatabaseIdentifier:11633513] ENSEMBL:ENSP00000506001 [DatabaseIdentifier:11633517] ENSEMBL:ENSP00000475557 [DatabaseIdentifier:11633516] ENSEMBL:ENSP00000475176 [DatabaseIdentifier:11633514] ENSEMBL:ENSP00000505359 [DatabaseIdentifier:11756214] ENSEMBL:ENST00000472977 [DatabaseIdentifier:11756213] ENSEMBL:ENST00000680288 [DatabaseIdentifier:11756216] ENSEMBL:ENST00000607427 [DatabaseIdentifier:11756212] ENSEMBL:ENST00000368985 [DatabaseIdentifier:11756215] ENSEMBL:ENST00000681444 [DatabaseIdentifier:11781067] Guide to Pharmacology - Targets:2353 [DatabaseIdentifier:11789114] GeneCards:CTSS [DatabaseIdentifier:11804741] GlyGen:P25774 [DatabaseIdentifier:11842139] HPA:ENSG00000163131-CTSS [DatabaseIdentifier:12126734] OpenTargets:ENSG00000163131 [DatabaseIdentifier:12188836] PDB:4P6G [DatabaseIdentifier:12188811] PDB:6YYQ [DatabaseIdentifier:12188828] PDB:2HXZ [DatabaseIdentifier:12188824] PDB:8RND [DatabaseIdentifier:12188795] PDB:5QBZ [DatabaseIdentifier:12188794] PDB:5QC9 [DatabaseIdentifier:12188798] PDB:5QC2 [DatabaseIdentifier:12188830] PDB:2HH5 [DatabaseIdentifier:12188813] PDB:2FT2 [DatabaseIdentifier:12188796] PDB:1NPZ [DatabaseIdentifier:12188790] PDB:5QBV [DatabaseIdentifier:12188834] PDB:2FUD [DatabaseIdentifier:12188822] PDB:5QCJ [DatabaseIdentifier:12188780] PDB:2R9M
databaseName	UniProt
dbId	51442
description	recommendedName: Cathepsin S ecNumber: 3.4.22.27
displayName	UniProt:P25774 CTSS
geneName	CTSS
identifier	P25774
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cytoplasmic vesicle Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Protease Proteomics identification Reference proteome Secreted Signal Thiol protease Zymogen
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	CTSS
otherIdentifier	11719554_at 11749589_x_at 1520 16692834 202901_PM_x_at 202901_x_at 202902_PM_s_at 202902_s_at 232617_PM_at 232617_at 2434576 2434577 2434578 2434579 2434580 2434581 2434582 2434583 2434584 2434589 2434591 2434592 2434593 2434594 2434595 2434596 2434598 2434599 2434600 41239_r_at 65578_at 7919800 A_23_P46141 A_24_P242646 GE61720 GE86289 GO:0001968 GO:0002224 GO:0002250 GO:0002376 GO:0002577 GO:0004197 GO:0004252 GO:0005515 GO:0005518 GO:0005576 GO:0005615 GO:0005764 GO:0005768 GO:0005770 GO:0006508 GO:0006955 GO:0008233 GO:0008234 GO:0010447 GO:0016485 GO:0016787 GO:0019882 GO:0019886 GO:0022617 GO:0030198 GO:0030312 GO:0030574 GO:0031012 GO:0031410 GO:0034769 GO:0036021 GO:0043202 GO:0043236 GO:0043394 GO:0045335 GO:0048002 GO:0051603 GO:0097067 GO:1904724 GO:1904813 GO:2001259 HMNXSV003014522 Hs.181301.1.S1_3p_at ILMN_1743032 M90696_at PH_hs_0010728 TC01003210.hg g12803614_3p_x_at g4758097_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1679012] CTSS [endolysosome lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1181234] CTSS [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801308] CTSS [tertiary granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801535] CTSS [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801274] CTSS [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1236751] CTSS [early endosome lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000163131] ENSEMBL:ENSG00000163131 CTSS [ReferenceDNASequence:12712847] UCSC:P25774 CTSS [ReferenceDNASequence:11380514] BioGPS Gene:1520 CTSS [ReferenceDNASequence:11395707] COSMIC - genes:CTSS CTSS [ReferenceDNASequence:11415651] CTD Gene:1520 CTSS [ReferenceDNASequence:11431964] dbSNP Gene:1520 CTSS [ReferenceDNASequence:11820766] HGNC:2545 CTSS [ReferenceDNASequence:11917507] KEGG:hsa:1520 CTSS [ReferenceDNASequence:12010303] Monarch:1520 CTSS [ReferenceDNASequence:12094396] NCBI Gene:1520 CTSS [ReferenceDNASequence:12111692] OMIM:116845 CTSS
referenceTranscript	[ReferenceRNASequence:12642806] RefSeq:NM_004079.4 CTSS [ReferenceRNASequence:12642805] RefSeq:NM_001199739.2 CTSS
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CATS_HUMAN B4DWC9 D3DV05 Q5T5I0 Q6FHS5 Q9BUG3
sequenceLength	331
species	[Species:48887] Homo sapiens
stId	uniprot:P25774
url	http://purl.uniprot.org/uniprot/P25774

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[UndirectedInteraction:11220733] UniProt:P14316 <-> UniProt:P25774 (IntAct)

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