Reactome | UniProt:P25441 RPC53

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UniProt:P25441 RPC53 Show undefined attributes

chain	chain:1-422
checksum	206FBAC274BC72D5
comment	FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.SUBUNIT Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC37/RPC5. RPC53/RPC4, RPC37/RPC5 and RPC11/RPC10 probably form a Pol III subcomplex.INTERACTION Present with 998 molecules/cell in log phase SD medium.SIMILARITY Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.
crossReference	[DatabaseIdentifier:12450922] RefSeq:NP_010131.1 [DatabaseIdentifier:12262397] PRO:P25441 [DatabaseIdentifier:12138670] PDB:6EU0 [DatabaseIdentifier:12138671] PDB:6EU3 [DatabaseIdentifier:12138682] PDB:6TUT [DatabaseIdentifier:12138668] PDB:6F44 [DatabaseIdentifier:12138674] PDB:6F40 [DatabaseIdentifier:12138687] PDB:5FJ9 [DatabaseIdentifier:12138679] PDB:6CNC [DatabaseIdentifier:12138680] PDB:7Z1O [DatabaseIdentifier:12138667] PDB:5FJ8 [DatabaseIdentifier:12138669] PDB:6EU1 [DatabaseIdentifier:12138677] PDB:6CND [DatabaseIdentifier:12138688] PDB:7Z30 [DatabaseIdentifier:12138681] PDB:6CNF [DatabaseIdentifier:12138672] PDB:6F41 [DatabaseIdentifier:12138685] PDB:5FJA [DatabaseIdentifier:12138684] PDB:7Z1M [DatabaseIdentifier:12138690] PDB:8BWS [DatabaseIdentifier:12138673] PDB:6EU2 [DatabaseIdentifier:12138676] PDB:6CNB [DatabaseIdentifier:12138689] PDB:7Z31 [DatabaseIdentifier:12138666] PDB:7Z0H [DatabaseIdentifier:12138675] PDB:6F42 [DatabaseIdentifier:12138683] PDB:7Z1L [DatabaseIdentifier:12138686] PDB:7Z2Z [DatabaseIdentifier:11748737] ENSEMBL:YDL150W_mRNA [DatabaseIdentifier:11626038] ENSEMBL:YDL150W [DatabaseIdentifier:11510930] ENSEMBL:YDL150W
databaseName	UniProt
dbId	100522
description	recommendedName: DNA-directed RNA polymerase III subunit RPC4 shortName: RNA polymerase III subunit C4 alternativeName: C53 alternativeName: DNA-directed RNA polymerase III 47 kDa polypeptide
displayName	UniProt:P25441 RPC53
geneName	RPC53 RPC4 YDL150W D1557
identifier	P25441
isSequenceChanged	false
keyword	3D-structure DNA-directed RNA polymerase Nucleus Phosphoprotein Reference proteome Transcription
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	RPC53
otherIdentifier	851404 GO:0000428 GO:0003677 GO:0003899 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005666 GO:0006352 GO:0006353 GO:0006383 GO:0006384 GO:0006386 GO:0016740 GO:0016779 GO:0042797
physicalEntity	[EntityWithAccessionedSequence:R-SCE-111822] RPC4_YEAST [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-83704] RPC53 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12709476] UCSC:P25441 RPC53 [ReferenceDNASequence:12089573] NCBI Gene:851404 RPC53 [ReferenceDNASequence:12005480] Monarch:851404 RPC53 [ReferenceDNASequence:11913279] KEGG:sce:YDL150W RPC53 [ReferenceDNASequence:11375691] BioGPS Gene:851404 RPC53
referenceTranscript	[ReferenceRNASequence:12632478] RefSeq:NM_001180210.1 RPC53
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RPC4_YEAST D6VRJ8 Q12073
sequenceLength	422
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P25441
url	http://purl.uniprot.org/uniprot/P25441

Referrals

(interactor)	[UndirectedInteraction:11151211] UniProt:P41910 <-> UniProt:P25441 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-111822] RPC4_YEAST [nucleoplasm] [EntityWithAccessionedSequence:R-SCE-83704] RPC53 [nucleoplasm]

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