UniProt:P25090 FPR2

chain
  • chain:1-351
checksum DC6A1D77AFC0D780
comment
  • FUNCTION Pattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated molecular patterns (PAMPs and DAMPs) (PubMed:1374236, PubMed:25605714, PubMed:35217703). Preferentially recognizes longer peptides or peptides with specific sequences such as the phenol-soluble modulin (PSM) family of formylated peptide toxins produced by Staphylococcus aureus (PubMed:30098280). Ligand binding causes a conformation change that triggers signaling via G(i)/GNAI1 inhibiting adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:40080544). In addition, can recognize a variety of chemically distinct endogenous ligands including proteins and lipids besides formylpeptides and thereby plays multiple roles in inflammation. Acts as a receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). Acts also as a ceramide membrane receptor, and long-chain ceramides (C14 to C20) binding induces conformational changes that inhibits diet-induced adipose thermogenesis (PubMed:40080544). Participates in neuroprotection via interaction with humanin/MT-RNR2 and Amyloid-beta protein 42, product of APP (PubMed:11689470, PubMed:35365641). Differential signaling is also defined by receptor oligomerization state. Binding of ANXA1 to FPR2 homodimer elicits activation of p38 MAPKinase pathway leading to HSPB1/HSP27 phosphorylation and IL10 production in monocytes. Whereas agonistic activation of FPR1:FPR2 heterodimers signals a proapoptotic JNK pathway in neutrophils.SUBUNIT Homodimer; the homodimerization is potentiated in response to the anti-inflammatory agonist ANXA1 and inhibited upon binding of pro-inflammatory agonist serum amyloid A (PubMed:24108355). Heterodimer with FPR1; the heterodimerization with FPR1 is potentiated in response to anti-inflammatory agonists such as lipoxin A4, ANXA1 and Ac2-26 ANXA1 peptide (PubMed:24108355). Forms a complex with heterotrimeric G(i) protein composed of GNAI1, GNB1 and GNG2 subunits (PubMed:35217703). Interacts with amyloid-beta protein 42, product of APP; the interaction takes place at the cell surface and the complex is then rapidly internalized (PubMed:11689470, PubMed:35365641). Interacts with S1PR4 (By similarity). Interacts with GNAI1 (PubMed:40080544). Interacts with humanin/MT-RNR2 (PubMed:35365641). Interacts with GNAI2 (PubMed:35365641).SUBUNIT (Microbial infection) Interacts with Staphylococcus aureus protein SSL13; this interaction leads to the activation of neutrophils.INTERACTION Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011).TISSUE SPECIFICITY Detected in lung, bone marrow, neutrophils, spleen and testis.SIMILARITY Belongs to the G-protein coupled receptor 1 family.
crossReference
databaseName UniProt
dbId 54916
description
  • recommendedName: N-formyl peptide receptor 2 alternativeName: FMLP-related receptor I shortName: FMLP-R-I alternativeName: Formyl peptide receptor-like 1 alternativeName: HM63 alternativeName: Lipoxin A4 receptor shortName evidence="16"ALX shortName: LXA4 receptor alternativeName: RFP
displayName UniProt:P25090 FPR2
geneName
  • FPR2
  • FPRH1
  • FPRL1
  • LXA4R
identifier P25090
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Chemotaxis
  • Disulfide bond
  • G-protein coupled receptor
  • Glycoprotein
  • Immunity
  • Inflammatory response
  • Innate immunity
  • Membrane
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Transducer
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • FPR2
otherIdentifier
  • 11734034_a_at
  • 11734035_a_at
  • 11739140_a_at
  • 16864751
  • 210772_PM_at
  • 210772_at
  • 210773_PM_s_at
  • 210773_s_at
  • 2358
  • 37095_r_at
  • 3839911
  • 3839912
  • 3839914
  • 3839915
  • 3839916
  • 3839917
  • 8030860
  • A_14_P200556
  • A_23_P55649
  • D10922_s_at
  • GE88015
  • GO:0001540
  • GO:0001774
  • GO:0002376
  • GO:0002430
  • GO:0002768
  • GO:0004875
  • GO:0004930
  • GO:0004982
  • GO:0005124
  • GO:0005515
  • GO:0005737
  • GO:0005886
  • GO:0006898
  • GO:0006935
  • GO:0006954
  • GO:0007154
  • GO:0007155
  • GO:0007165
  • GO:0007166
  • GO:0007186
  • GO:0007193
  • GO:0007200
  • GO:0007204
  • GO:0016020
  • GO:0016192
  • GO:0019722
  • GO:0023052
  • GO:0032930
  • GO:0035579
  • GO:0038023
  • GO:0038024
  • GO:0042742
  • GO:0043524
  • GO:0045089
  • GO:0048143
  • GO:0050728
  • GO:0050766
  • GO:0050786
  • GO:0050918
  • GO:0051897
  • GO:0070374
  • GO:0070821
  • GO:0090026
  • GO:0097187
  • GO:0098542
  • GO:0101003
  • GO:1904646
  • HMNXSV003033568
  • ILMN_1740875
  • ILMN_2392569
  • PH_hs_0029057
  • PH_hs_0031471
  • TC19000788.hg
  • g1916075_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FPR2_HUMAN
  • A8K3E2
sequenceLength 351
species [Species:48887] Homo sapiens
stId uniprot:P25090
url http://purl.uniprot.org/uniprot/P25090

Referrals

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