UniProt:P24898 Junb

chain
  • chain:1-344
checksum 6F52D4FECC32E234
comment
  • FUNCTION Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).SUBUNIT Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Component of an AP-1 transcription factor complex (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with NFE2 (via its WW domains).SUBCELLULAR LOCATION By growth factors.PTM Ubiquitinated by ITCH, leading to its degradation.SIMILARITY Belongs to the bZIP family. Jun subfamily.
crossReference
databaseName UniProt
dbId 93534
description
  • recommendedName: fullName evidence="6"Transcription factor JunB alternativeName: fullName evidence="6"Transcription factor AP-1 subunit JunB
displayName UniProt:P24898 Junb
geneName
  • Junb
  • Jun-b
identifier P24898
isSequenceChanged false
keyword
  • Acetylation
  • DNA-binding
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Junb
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • JUNB_RAT
  • Q6P733
sequenceLength 344
species [Species:48895] Rattus norvegicus
stId uniprot:P24898
url http://purl.uniprot.org/uniprot/P24898
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