Reactome | UniProt:P23528 CFL1

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UniProt:P23528 CFL1 Show undefined attributes

chain	initiator methionine:1 chain:2-166
checksum	589EF8FC1EC13719
comment	FUNCTION Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).SUBUNIT Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (PubMed:11812157). It is a major component of intranuclear and cytoplasmic actin rods (By similarity). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 isoform 1 and NLRP5 (By similarity). Interacts with C9orf72 (By similarity).SUBUNIT (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) matrix protein; this interaction probably facilitates viral replication.INTERACTION Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.TISSUE SPECIFICITY Widely distributed in various tissues.INDUCTION Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).PTM Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.SIMILARITY Belongs to the actin-binding proteins ADF family.ONLINE INFORMATION Cofilin entry
crossReference	[DatabaseIdentifier:11476935] ENSEMBL:ENSG00000172757 [DatabaseIdentifier:12378363] RefSeq:NP_005498.1 [DatabaseIdentifier:12288246] Pharos - Targets:P23528 [DatabaseIdentifier:12269611] PRO:P23528 [DatabaseIdentifier:12202939] PDB:6UC4 [DatabaseIdentifier:12202936] PDB:6VAO [DatabaseIdentifier:12202937] PDB:1Q8G [DatabaseIdentifier:12202934] PDB:6UC0 [DatabaseIdentifier:12202938] PDB:4BEX [DatabaseIdentifier:12142706] PDB:5HVK [DatabaseIdentifier:12192310] PDB:3J0S [DatabaseIdentifier:12202940] PDB:9H1F [DatabaseIdentifier:12202935] PDB:1Q8X [DatabaseIdentifier:12202941] PDB:6UBY [DatabaseIdentifier:12142707] PDB:5L6W [DatabaseIdentifier:12128022] OpenTargets:ENSG00000172757 [DatabaseIdentifier:11576503] ENSEMBL:ENSP00000309629 [DatabaseIdentifier:11576504] ENSEMBL:ENSP00000432660 [DatabaseIdentifier:11699203] ENSEMBL:ENST00000525451 [DatabaseIdentifier:11699202] ENSEMBL:ENST00000308162 [DatabaseIdentifier:11790403] GeneCards:CFL1 [DatabaseIdentifier:11806311] GlyGen:P23528 [DatabaseIdentifier:11843414] HPA:ENSG00000172757-CFL1
databaseName	UniProt
dbId	52508
description	recommendedName: Cofilin-1 alternativeName: 18 kDa phosphoprotein shortName: p18 alternativeName: Cofilin, non-muscle isoform
displayName	UniProt:P23528 CFL1
geneName	CFL1 CFL
identifier	P23528
isSequenceChanged	false
keyword	3D-structure Acetylation Actin-binding Cell membrane Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Host-virus interaction Isopeptide bond Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	CFL1
otherIdentifier	1072 11753645_a_at 11753646_x_at 11754158_a_at 11757818_x_at 11763259_x_at 1555730_PM_a_at 1555730_a_at 16654131 16654133 16654139 16654153 16654207 16654209 16654211 16654213 16654215 16654217 16654233 16654235 16654237 16654239 16654241 16654243 18671389 18671390 18671391 18671392 18671393 18671394 18671395 18671396 18671397 18671398 18671399 18671400 18671401 18671402 18671403 18671404 18671405 18671406 18671407 200021_PM_at 200021_at 236792_PM_at 236792_at 33659_at 3377887 3377888 3377889 3377890 3377891 3377892 3377893 3377894 3377895 3377896 3377897 3377898 3377899 3377900 3377901 3377902 3377904 3377905 3377906 3377910 3377912 3377914 3377916 75185_f_at 76366_at 76368_at 7892701 7894264 7895149 7895299 7895945 7896038 7949496 A_21_P0011012 GE79937 GE833765 GO:0000281 GO:0000910 GO:0001755 GO:0001842 GO:0003779 GO:0005102 GO:0005515 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005925 GO:0006606 GO:0006886 GO:0006913 GO:0007010 GO:0007015 GO:0007162 GO:0007163 GO:0007266 GO:0008092 GO:0008154 GO:0009615 GO:0010592 GO:0010593 GO:0014823 GO:0015629 GO:0016020 GO:0016363 GO:0019903 GO:0021766 GO:0022604 GO:0030010 GO:0030027 GO:0030030 GO:0030036 GO:0030042 GO:0030043 GO:0030175 GO:0030307 GO:0030424 GO:0030426 GO:0030835 GO:0030836 GO:0030864 GO:0031252 GO:0031258 GO:0031915 GO:0031966 GO:0031982 GO:0032232 GO:0032587 GO:0040019 GO:0042995 GO:0043025 GO:0043066 GO:0043197 GO:0043200 GO:0043226 GO:0044794 GO:0045792 GO:0045862 GO:0048856 GO:0048870 GO:0050804 GO:0051014 GO:0051015 GO:0051293 GO:0051511 GO:0051894 GO:0060999 GO:0061001 GO:0070062 GO:0070301 GO:0071347 GO:0071354 GO:0071356 GO:0071362 GO:0071364 GO:0090732 GO:0097060 GO:0098885 GO:0098978 GO:0099092 GO:1902936 GO:1902951 GO:1905873 GO:1905875 GO:1990314 GO:2000146 GO:2000147 GO:2000784 GO:2000814 HMNXSV003014976 HMNXSV003053161 Hs.121449.0.A1_3p_at Hs2.180370.2.S1_3p_s_at ILMN_1705617 TC11001944.hg TC11001945.hg X95404_at g5031634_3p_at g5031634_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-350751] CFL1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-399813] p-S3-CFL1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-350747] CFL1 [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12112830] OMIM:601442 CFL1 [ReferenceDNASequence:12690093] UCSC:P23528 CFL1 [ReferenceDNASequence:ensembl:ENSG00000172757] ENSEMBL:ENSG00000172757 CFL1 [ReferenceDNASequence:11342367] BioGPS Gene:1072 CFL1 [ReferenceDNASequence:11392912] COSMIC - genes:CFL1 CFL1 [ReferenceDNASequence:11417768] CTD Gene:1072 CFL1 [ReferenceDNASequence:11428826] dbSNP Gene:1072 CFL1 [ReferenceDNASequence:11822064] HGNC:1874 CFL1 [ReferenceDNASequence:11882947] KEGG:hsa:1072 CFL1 [ReferenceDNASequence:11972156] Monarch:1072 CFL1 [ReferenceDNASequence:12056249] NCBI Gene:1072 CFL1
referenceTranscript	[ReferenceRNASequence:12560146] RefSeq:NM_005507.3 CFL1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	COF1_HUMAN B3KUQ1 Q53Y87 Q9UCA2
sequenceLength	166
species	[Species:48887] Homo sapiens
stId	uniprot:P23528
url	http://purl.uniprot.org/uniprot/P23528

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-350751] CFL1 [cytosol] [EntityWithAccessionedSequence:R-HSA-399813] p-S3-CFL1 [cytosol] [EntityWithAccessionedSequence:R-HSA-350747] CFL1 [extracellular region]
(referenceSequence)	[ModifiedResidue:399814] O-phospho-L-serine at 3
(interactor)	[UndirectedInteraction:11149305] UniProt:P13569 <-> UniProt:P23528 (IntAct) [UndirectedInteraction:11156537] UniProt:P23528 <-> UniProt:P60709 (IntAct) [UndirectedInteraction:11156539] UniProt:P23528 <-> UniProt:P63261 (IntAct) [UndirectedInteraction:11156541] UniProt:P23528 <-> UniProt:P53667 (IntAct) [UndirectedInteraction:11156543] UniProt:P23528 <-> UniProt:P54253 (IntAct) [UndirectedInteraction:11156545] UniProt:P23528 <-> UniProt:P00533 (IntAct) [UndirectedInteraction:11156547] UniProt:P23528 <-> UniProt:P63104 (IntAct) [UndirectedInteraction:11156549] UniProt:P23528 <-> UniProt:P40123 (IntAct) [UndirectedInteraction:11156551] UniProt:P23528 <-> UniProt:P32121 (IntAct) [UndirectedInteraction:11156553] UniProt:P23528 <-> UniProt:P49407 (IntAct) [UndirectedInteraction:11156555] UniProt:P23528 <-> UniProt:Q13393 (IntAct) [UndirectedInteraction:11156557] UniProt:P23528 <-> UniProt:P10636-8 (IntAct) [UndirectedInteraction:11156559] UniProt:P23528 <-> UniProt:P68032 (IntAct) [UndirectedInteraction:11156563] UniProt:P23528 <-> UniProt:Q549N0 (IntAct) [UndirectedInteraction:11156565] UniProt:P23528 <-> UniProt:Q96CV9 (IntAct) [UndirectedInteraction:11156569] UniProt:P23528 <-> UniProt:Q1KLZ0 (IntAct) [UndirectedInteraction:11156571] UniProt:P23528 <-> UniProt:Q15303 (IntAct) [UndirectedInteraction:11156575] UniProt:P23528 <-> UniProt:Q9Y281 (IntAct) [UndirectedInteraction:11156577] UniProt:P23528 <-> UniProt:O14939 (IntAct) [UndirectedInteraction:11156579] UniProt:P23528 <-> UniProt:P01106 (IntAct) [UndirectedInteraction:11156581] UniProt:P23528 <-> UniProt:P15336 (IntAct) [UndirectedInteraction:11156585] UniProt:P23528 <-> UniProt:P57058 (IntAct) [UndirectedInteraction:11156587] UniProt:P23528 <-> UniProt:P0DOE7 (IntAct) [UndirectedInteraction:11156589] UniProt:P23528 <-> UniProt:P61981 (IntAct) [UndirectedInteraction:11156591] UniProt:P23528 <-> ChEBI:16851 (IntAct) [UndirectedInteraction:11156593] UniProt:P23528 <-> ChEBI:18348 (IntAct)