Reactome | UniProt:P23511 NFYA

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UniProt:P23511 NFYA Show undefined attributes

chain	chain:1-347
checksum	D00BE17041EB1A9E
comment	FUNCTION Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1.SUBUNIT Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3.INTERACTION Belongs to the NFYA/HAP2 subunit family.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:12378767] RefSeq:NP_002496.1 [DatabaseIdentifier:12378768] RefSeq:NP_068351.1 [DatabaseIdentifier:12288378] Pharos - Targets:P23511 [DatabaseIdentifier:12269844] PRO:P23511 [DatabaseIdentifier:12163414] PDB:8QU2 [DatabaseIdentifier:12163415] PDB:8QU3 [DatabaseIdentifier:12163407] PDB:8QU4 [DatabaseIdentifier:12163411] PDB:6QMP [DatabaseIdentifier:12163410] PDB:6QMQ [DatabaseIdentifier:12163413] PDB:4AWL [DatabaseIdentifier:12163412] PDB:6QMS [DatabaseIdentifier:12128154] OpenTargets:ENSG00000001167 [DatabaseIdentifier:11843542] HPA:ENSG00000001167-NFYA [DatabaseIdentifier:11806497] GlyGen:P23511 [DatabaseIdentifier:11790536] GeneCards:NFYA [DatabaseIdentifier:11699456] ENSEMBL:ENST00000353205 [DatabaseIdentifier:11699457] ENSEMBL:ENST00000341376 [DatabaseIdentifier:11576758] ENSEMBL:ENSP00000229418 [DatabaseIdentifier:11576757] ENSEMBL:ENSP00000345702 [DatabaseIdentifier:11477150] ENSEMBL:ENSG00000001167
databaseName	UniProt
dbId	403380
description	recommendedName: Nuclear transcription factor Y subunit alpha alternativeName: CAAT box DNA-binding protein subunit A alternativeName: Nuclear transcription factor Y subunit A shortName: NF-YA
displayName	UniProt:P23511 NFYA
geneName	NFYA
identifier	P23511
isSequenceChanged	false
keyword	3D-structure Activator Alternative splicing Biological rhythms DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	NFYA
physicalEntity	[EntityWithAccessionedSequence:R-HSA-420841] NFYA [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12690264] UCSC:P23511 NFYA [ReferenceDNASequence:12112952] OMIM:189903 NFYA [ReferenceDNASequence:12056454] NCBI Gene:4800 NFYA [ReferenceDNASequence:11972361] Monarch:4800 NFYA [ReferenceDNASequence:11883136] KEGG:hsa:4800 NFYA [ReferenceDNASequence:11822197] HGNC:7804 NFYA [ReferenceDNASequence:11428831] dbSNP Gene:4800 NFYA [ReferenceDNASequence:11417974] CTD Gene:4800 NFYA [ReferenceDNASequence:11392916] COSMIC - genes:NFYA NFYA [ReferenceDNASequence:11342572] BioGPS Gene:4800 NFYA [ReferenceDNASequence:ensembl:ENSG00000001167] ENSEMBL:ENSG00000001167 NFYA
referenceTranscript	[ReferenceRNASequence:12560549] RefSeq:NM_021705.4 NFYA [ReferenceRNASequence:12560550] RefSeq:NM_002505.5 NFYA
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NFYA_HUMAN Q8IXU0
sequenceLength	347
species	[Species:48887] Homo sapiens
stId	uniprot:P23511
url	http://purl.uniprot.org/uniprot/P23511

Referrals

(interactor)	[UndirectedInteraction:11294859] UniProt:P68400 <-> UniProt:P23511 (IntAct) [UndirectedInteraction:11290017] UniProt:Q07955 <-> UniProt:P23511 (IntAct) [UndirectedInteraction:11200393] UniProt:P04637 <-> UniProt:P23511 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-420841] NFYA [nucleoplasm]

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