Reactome | UniProt:P23467 PTPRB

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UniProt:P23467 PTPRB Show undefined attributes

chain	signal peptide:1-22 chain:23-1997
checksum	76E67B4A6109AA0F
comment	FUNCTION Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateSUBUNIT Monomer. Interacts with TEK (PubMed:19451274). Interacts via fibronectin type-III 17 domain with CDH5. Detected in a complex with CNTN1 and NRCAM (By similarity). Interacts (phosphorylated form) with FYN and GRB2 (By similarity). Interacts with IGFBP2 (PubMed:22869525).INTERACTION Up-regulated by hypoxia.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
crossReference	[DatabaseIdentifier:12377218] RefSeq:NP_001193901.1 [DatabaseIdentifier:12815230] ZINC target:P23467 [DatabaseIdentifier:12811884] ZINC - Substances:PTPRB_HUMAN [DatabaseIdentifier:12809848] ZINC - Predictions - Purchasable:PTPRB_HUMAN [DatabaseIdentifier:12377220] RefSeq:NP_001317133.1 [DatabaseIdentifier:12377219] RefSeq:NP_001193900.1 [DatabaseIdentifier:12377217] RefSeq:NP_002828.3 [DatabaseIdentifier:12377216] RefSeq:NP_001103224.1 [DatabaseIdentifier:11476360] ENSEMBL:ENSG00000127329 [DatabaseIdentifier:11575821] ENSEMBL:ENSP00000334928 [DatabaseIdentifier:11575822] ENSEMBL:ENSP00000438927 [DatabaseIdentifier:11575823] ENSEMBL:ENSP00000261266 [DatabaseIdentifier:11575824] ENSEMBL:ENSP00000447302 [DatabaseIdentifier:11698522] ENSEMBL:ENST00000550857 [DatabaseIdentifier:11698523] ENSEMBL:ENST00000538708 [DatabaseIdentifier:11698521] ENSEMBL:ENST00000261266 [DatabaseIdentifier:11698520] ENSEMBL:ENST00000334414 [DatabaseIdentifier:11780287] Guide to Pharmacology - Targets:1851 [DatabaseIdentifier:11790178] GeneCards:PTPRB [DatabaseIdentifier:11805998] GlyGen:P23467 [DatabaseIdentifier:11830733] HMDB Protein:HMDBP08940 [DatabaseIdentifier:11843197] HPA:ENSG00000127329-PTPRB [DatabaseIdentifier:12127798] OpenTargets:ENSG00000127329 [DatabaseIdentifier:12194788] PDB:2AHS [DatabaseIdentifier:12194792] PDB:2I3U [DatabaseIdentifier:12194787] PDB:8JBN [DatabaseIdentifier:12194797] PDB:2I4H [DatabaseIdentifier:12194791] PDB:2H03 [DatabaseIdentifier:12194798] PDB:2I4G [DatabaseIdentifier:12194793] PDB:2H02 [DatabaseIdentifier:12194794] PDB:2HC2 [DatabaseIdentifier:12194799] PDB:2I4E [DatabaseIdentifier:12194786] PDB:2I3R [DatabaseIdentifier:12194789] PDB:2H04 [DatabaseIdentifier:12194790] PDB:2I5X [DatabaseIdentifier:12194796] PDB:8JBY [DatabaseIdentifier:12194795] PDB:2HC1 [DatabaseIdentifier:12269158] PRO:P23467 [DatabaseIdentifier:12288027] Pharos - Targets:P23467
databaseName	UniProt
dbId	62457
description	recommendedName: Receptor-type tyrosine-protein phosphatase beta shortName: Protein-tyrosine phosphatase beta shortName: R-PTP-beta ecNumber: 3.1.3.48 alternativeName: Vascular endothelial protein tyrosine phosphatase shortName: VE-PTP
displayName	UniProt:P23467 PTPRB
geneName	PTPRB PTPB
identifier	P23467
isSequenceChanged	false
keyword	3D-structure Alternative splicing Angiogenesis Glycoprotein Hydrolase Membrane Phosphoprotein Protein phosphatase Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	PTPRB
otherIdentifier	11733229_a_at 11733230_a_at 11733231_a_at 11752192_x_at 11762476_at 16767422 205846_PM_at 205846_at 217177_PM_s_at 217177_s_at 230250_PM_at 230250_at 33066_at 3461796 3461797 3461798 3461799 3461800 3461801 3461802 3461803 3461804 3461805 3461809 3461812 3461813 3461815 3461816 3461817 3461820 3461823 3461824 3461825 3461826 3461827 3461828 3461831 3461832 3461833 3461834 3461837 3461838 3461839 3461840 3461841 3461842 3461843 3461844 3461845 3461848 3461849 3461850 3461851 3461852 3461853 3461854 3461855 3461859 3461862 3461865 3461866 3461868 3461869 3461870 3461874 3461875 3461876 3461877 3461878 3461879 37777_at 407_at 5787 7964872 A_23_P53390 A_24_P661612 A_32_P94851 GE56336 GE59789 GE874747 GO:0001525 GO:0001649 GO:0003824 GO:0004721 GO:0004725 GO:0005001 GO:0005515 GO:0005886 GO:0006470 GO:0006796 GO:0008347 GO:0016020 GO:0016311 GO:0016787 GO:0030154 GO:0032502 GO:0035579 GO:0043235 GO:0045296 GO:0045668 GO:0048870 GO:0070821 GO:0140096 HMNXSV003020137 HMNXSV003034151 Hs.123641.1.A1_3p_at Hs.149770.0.S1_3p_a_at ILMN_1672102 ILMN_1821052 PH_hs_0025326 TC12001718.hg X54131_at g4506304_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6799638] PTPRB [specific granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-437247] PTPRB [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801032] PTPRB [tertiary granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000127329] ENSEMBL:ENSG00000127329 PTPRB [ReferenceDNASequence:12689624] UCSC:P23467 PTPRB [ReferenceDNASequence:11341797] BioGPS Gene:5787 PTPRB [ReferenceDNASequence:11392900] COSMIC - genes:PTPRB PTPRB [ReferenceDNASequence:11417371] CTD Gene:5787 PTPRB [ReferenceDNASequence:11428813] dbSNP Gene:5787 PTPRB [ReferenceDNASequence:11821836] HGNC:9665 PTPRB [ReferenceDNASequence:11882462] KEGG:hsa:5787 PTPRB [ReferenceDNASequence:11971586] Monarch:5787 PTPRB [ReferenceDNASequence:12055679] NCBI Gene:5787 PTPRB [ReferenceDNASequence:12112631] OMIM:176882 PTPRB
referenceTranscript	[ReferenceRNASequence:12558998] RefSeq:NM_001109754.4 PTPRB [ReferenceRNASequence:12559001] RefSeq:NM_002837.5 PTPRB [ReferenceRNASequence:12559000] RefSeq:NM_001330204.1 PTPRB [ReferenceRNASequence:12558997] RefSeq:NM_001206971.3 PTPRB [ReferenceRNASequence:12558999] RefSeq:NM_001206972.3 PTPRB
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PTPRB_HUMAN B7ZKS8 B7ZKT0 C9JX87 F5H3G6 Q14D85 Q3MIV7
sequenceLength	1997
species	[Species:48887] Homo sapiens
stId	uniprot:P23467
url	http://purl.uniprot.org/uniprot/P23467

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6799638] PTPRB [specific granule membrane] [EntityWithAccessionedSequence:R-HSA-437247] PTPRB [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6801032] PTPRB [tertiary granule membrane]
(interactor)	[UndirectedInteraction:11158885] UniProt:P27361 <-> UniProt:P23467 (IntAct) [UndirectedInteraction:11234123] UniProt:P00533 <-> UniProt:P23467 (IntAct) [UndirectedInteraction:11248055] UniProt:P10912 <-> UniProt:P23467 (IntAct)