Reactome | UniProt:P22891 PROZ

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UniProt:P22891 PROZ Show undefined attributes

chain	signal peptide:1-23 propeptide:24-40 chain:41-400
checksum	7EBD2DCC48860268
comment	FUNCTION Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.SUBUNIT Interacts with SERPINA10.INTERACTION Plasma.PTM The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.SIMILARITY Belongs to the peptidase S1 family.CAUTION Although related to peptidase S1 family vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and therefore lacks protease activity.
crossReference	[DatabaseIdentifier:12425369] RefSeq:NP_001243063.1 [DatabaseIdentifier:12425370] RefSeq:NP_003882.1 [DatabaseIdentifier:11498509] ENSEMBL:ENSG00000126231 [DatabaseIdentifier:11607819] ENSEMBL:ENSP00000344458 [DatabaseIdentifier:11607818] ENSEMBL:ENSP00000364697 [DatabaseIdentifier:11730517] ENSEMBL:ENST00000342783 [DatabaseIdentifier:11730518] ENSEMBL:ENST00000375547 [DatabaseIdentifier:11791473] GeneCards:PROZ [DatabaseIdentifier:11833024] HMDB Protein:HMDBP02005 [DatabaseIdentifier:11844475] HPA:ENSG00000126231-PROZ [DatabaseIdentifier:12129102] OpenTargets:ENSG00000126231 [DatabaseIdentifier:12137296] Orphanet:PROZ [DatabaseIdentifier:12142557] PDB:3H5C [DatabaseIdentifier:12142558] PDB:3F1S [DatabaseIdentifier:12250941] PRO:P22891 [DatabaseIdentifier:12289314] Pharos - Targets:P22891
databaseName	UniProt
dbId	62253
description	recommendedName: Vitamin K-dependent protein Z
displayName	UniProt:P22891 PROZ
geneName	PROZ
identifier	P22891
isSequenceChanged	false
keyword	3D-structure Alternative splicing Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disulfide bond EGF-like domain Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydroxylation Proteomics identification Reference proteome Repeat Secreted Serine protease homolog Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PROZ
otherIdentifier	11738558_a_at 11744546_a_at 16776812 208034_PM_s_at 208034_s_at 3502476 3502477 3502478 3502479 3502480 3502482 3502483 3502485 3502486 3502487 3502488 3502489 3502490 3502491 3502492 3502493 3502494 37109_at 7970251 8858 A_23_P140074 GE53873 GO:0004252 GO:0005509 GO:0005515 GO:0005576 GO:0005615 GO:0005788 GO:0005796 GO:0006508 GO:0007596 GO:0007599 GO:0016787 GO:0070062 HMNXSV003040703 ILMN_1664565 M55671_at PH_hs_0000128 TC13000418.hg g4506120_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9932942] 13xCbxE-PROZ [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163816] PROZ(24-400) [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163838] 13xCbxE-PROZ(24-400) [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163827] 13xCbxE-PROZ(24-400) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163813] 13xCbxE-PROZ [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163834] PROZ(24-40) [Golgi lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000126231] ENSEMBL:ENSG00000126231 PROZ [ReferenceDNASequence:12755365] UCSC:P22891 PROZ [ReferenceDNASequence:11364026] BioGPS Gene:8858 PROZ [ReferenceDNASequence:11401979] COSMIC - genes:PROZ PROZ [ReferenceDNASequence:11419228] CTD Gene:8858 PROZ [ReferenceDNASequence:11439399] dbSNP Gene:8858 PROZ [ReferenceDNASequence:11823144] HGNC:9460 PROZ [ReferenceDNASequence:11902705] KEGG:hsa:8858 PROZ [ReferenceDNASequence:11993815] Monarch:8858 PROZ [ReferenceDNASequence:12077908] NCBI Gene:8858 PROZ [ReferenceDNASequence:12113791] OMIM:176895 PROZ
referenceTranscript	[ReferenceRNASequence:12606937] RefSeq:NM_003891.3 PROZ [ReferenceRNASequence:12606938] RefSeq:NM_001256134.2 PROZ
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PROZ_HUMAN A6NMB4 Q15213 Q5JVF5 Q5JVF6
sequenceLength	400
species	[Species:48887] Homo sapiens
stId	uniprot:P22891
url	http://purl.uniprot.org/uniprot/P22891

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9932942] 13xCbxE-PROZ [extracellular region] [EntityWithAccessionedSequence:R-HSA-163816] PROZ(24-400) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-163838] 13xCbxE-PROZ(24-400) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-163827] 13xCbxE-PROZ(24-400) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-163813] 13xCbxE-PROZ [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-163834] PROZ(24-40) [Golgi lumen]
(referenceSequence)	[ModifiedResidue:163808] L-gamma-carboxyglutamic acid at 48 [ModifiedResidue:163817] L-gamma-carboxyglutamic acid at 75 [ModifiedResidue:163822] L-gamma-carboxyglutamic acid at 51 [ModifiedResidue:163823] L-gamma-carboxyglutamic acid at 55 [ModifiedResidue:163821] L-gamma-carboxyglutamic acid at 67 [ModifiedResidue:163792] L-gamma-carboxyglutamic acid at 70 [ModifiedResidue:163793] L-gamma-carboxyglutamic acid at 47 [ModifiedResidue:163799] L-gamma-carboxyglutamic acid at 73 [ModifiedResidue:163829] L-gamma-carboxyglutamic acid at 60 [ModifiedResidue:163801] L-gamma-carboxyglutamic acid at 57 [ModifiedResidue:163833] L-gamma-carboxyglutamic acid at 61 [ModifiedResidue:163836] L-gamma-carboxyglutamic acid at 80 [ModifiedResidue:163837] L-gamma-carboxyglutamic acid at 66
(interactor)	[UndirectedInteraction:11172563] UniProt:Q9UK55 <-> UniProt:P22891 (IntAct) [UndirectedInteraction:11239829] UniProt:P22891 <-> UniProt:Q9NZV5 (IntAct) [UndirectedInteraction:11239831] UniProt:P22891 <-> UniProt:Q9UL03 (IntAct) [UndirectedInteraction:11239833] UniProt:P22891 <-> UniProt:Q6R327 (IntAct)

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