Reactome | UniProt:P22769 Prosalpha4

Schema > ReferenceGeneProduct > Entries

UniProt:P22769 Prosalpha4 Show undefined attributes

chain	chain:1-249
checksum	56987932DADD02B3
comment	FUNCTION The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.SUBUNIT The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with PI31; this interaction is reduced by PI31 ADP-ribosylation.INTERACTION Belongs to the peptidase T1A family.
crossReference	[DatabaseIdentifier:12424084] RefSeq:NP_525092.1 [DatabaseIdentifier:12250332] PRO:P22769 [DatabaseIdentifier:11775914] FlyBase:FBgn0004066 [DatabaseIdentifier:11729675] ENSEMBL:FBtr0074210 [DatabaseIdentifier:11606976] ENSEMBL:FBpp0073989 [DatabaseIdentifier:11497905] ENSEMBL:FBgn0004066
databaseName	UniProt
dbId	98988
description	recommendedName: Proteasome subunit alpha type-7-1 alternativeName: PROS-Dm28.1 alternativeName: Proteasome 28 kDa subunit 1
displayName	UniProt:P22769 Prosalpha4
geneName	Prosalpha4 PROS-28.1 Pros28.1 CG3422
identifier	P22769
isSequenceChanged	false
keyword	Cytoplasm Nucleus Phosphoprotein Proteasome Reference proteome
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	Prosalpha4
otherIdentifier	143422_at 1641485_at 32584 GO:0000502 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005839 GO:0006511 GO:0019773 GO:0030163 GO:0043161 GO:0051603
physicalEntity	[EntityWithAccessionedSequence:R-DME-216125] PROS28.1 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-206179] PROS28.1 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-174351] Prosalpha4 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-68736] Prosalpha4 [cytosol] - Drosophila melanogaster
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12754921] UCSC:P22769 Prosalpha4 [ReferenceDNASequence:12077320] NCBI Gene:32584 Prosalpha4 [ReferenceDNASequence:11993227] Monarch:32584 Prosalpha4 [ReferenceDNASequence:11902192] KEGG:dme:Dmel_CG3422 Prosalpha4 [ReferenceDNASequence:11418691] CTD Gene:32584 Prosalpha4 [ReferenceDNASequence:11363438] BioGPS Gene:32584 Prosalpha4
referenceTranscript	[ReferenceRNASequence:12605674] RefSeq:NM_080353.5 Prosalpha4
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PSA71_DROME Q9VXI9
sequenceLength	249
species	[Species:56210] Drosophila melanogaster
stId	uniprot:P22769
url	http://purl.uniprot.org/uniprot/P22769

Referrals

(interactor)	[UndirectedInteraction:11254613] UniProt:Q9XYN7 <-> UniProt:P22769 (IntAct) [UndirectedInteraction:11200037] UniProt:Q95083 <-> UniProt:P22769 (IntAct) [UndirectedInteraction:11191553] UniProt:Q9XZJ4 <-> UniProt:P22769 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-DME-216125] PROS28.1 [nucleoplasm] [EntityWithAccessionedSequence:R-DME-206179] PROS28.1 [cytosol] [EntityWithAccessionedSequence:R-DME-174351] Prosalpha4 [nucleoplasm] [EntityWithAccessionedSequence:R-DME-68736] Prosalpha4 [cytosol]